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Registry-based randomised controlled trials (R-RCTs) represent a paradigm shift in research, with the potential to accomplish pragmatic but large trials with high external validity. In this paper, we review our experiences from planning and performing the REgistry-based randomised controlled trial of treatment Duration and mortality in long-term OXygen therapy (REDOX) trial, the first R-RCT within

Accurate imputation is essential for the reliability and success of downstream tasks. Recently, diffusion models have attracted great attention in this field. However, these models neglect the latent distribution in a lower-dimensional space derived from the observed data, which limits the generative capacity of the diffusion model. Additionally, dealing with the original missing data without labe

Aim: To assess the prognostic value of auditory event-related potentials (AERPs) registered at term equivalent age in very preterm infants. Methods: Infants (26.5 ± 2.0 gestational weeks (GWs), n = 41 of 64 recruited) were enrolled prenatally between January 2005 and May 2007 at Skåne University Hospital, Lund, Sweden. AERP and mismatch responses to changes in duration or frequency in pure tones w

In this chapter, we introduce the configuration of caring cuts. Composed of care and cuts, two key notions in feminist posthumanism and Actor-Network Theory (ANT), caring cuts addresses the entanglement of epistemology and ontology. By putting to work an ontology of relational materialisms, the chapter explores how to respond to the mess, emergence, and elusive objects that become centred by our c

Insects are known for communicating via sounds created by rubbing body parts, a behaviour referred to as stridulation. Red Wood ants (Formica rufa group) are not known to possess stridulatory organs and have historically been categorised as a non-stridulating species. In this exploratory study, we report that Red Wood ants generate stridulation-like sounds, being about 0.7 ± 0.2 seconds-long (mean

Introduction: The rat Vra1 locus, containing glutathione S-transferase alpha 4 (Gsta4), regulates the degeneration of central nervous system (CNS) neurons in toxin-, protein-, and injury-based models. We hypothesize that Piebald Virol Glaxo.1AV1 (PVG) alleles in Vra1 confer protection and increased axonal outgrowth after peripheral nerve injury and repair. Methods: DA rats (n = 14) and DA rats wit

Frequent wildfires increasingly impact tourist populations, yet there is a shortage of evidence-based, human-centered tools for wildfire risk reduction tailored to these areas. Most current tools focus primarily on assessing and reducing physical vulnerabilities, overlooking human aspects. While some community wildfire management guidelines exist, actionable strategies for disaster managers to add

Tracking animal displacement on video recording is a frequently used method in ethology, behavioral ecology, and neuroscience to characterize animal behavior in an automated and objective way. We propose here a quick-start tutorial of AnimalTA, a video tracking program, which aims to provide a free, open-source, and user-friendly tool for the scientific community. The strength of this software res

Recent studies provide insights about local agency in regional development. While acknowledging non-local actors and drivers, these studies have not systematically discussed the link between extra-regional relations and local agency. This paper first discusses three key arguments in the literature on extra-regional relations covering context-specific dependencies, strategic coupling and open innov

Purpose: To introduce a newly developed digital platform and compare its reliability and agreement with paper-based questionnaires for assessing quality of vision before and after cataract surgery. Setting: University-affiliated ophthalmology department and private clinic. Design: Prospective, randomized trial with parallel design of 1:1 allocation ratio without masking. Methods: Between 11/2021 a

We present a next-to-leading order calculation of Higgs boson production plus one and two jets via gluon fusion interfaced to shower Monte Carlo programs, implemented according to the POWHEG method. For this implementation we have used a new interface of the POWHEG BOX with MadGraph4, that generates the codes for generic Born and real processes automatically. The virtual corrections have been take

The next-to-leading order accuracy for MC@NLO results exclusive in J light jets is achieved if the computation is based on matrix elements that feature J and J + 1 QCD partons. The simultaneous prediction of observables which are exclusive in different light-jet multiplicities cannot simply be obtained by summing the above results over the relevant range in J; rather, a suitable merging procedure

We present predictions for the SM-Higgs-pair production channels of relevance at the LHC: gluon-gluon fusion, VBF, and top-pair, W, Z and single-top associated production. All these results are at the NLO accuracy in QCD, and matched to parton showers by means of the MC@NLO method; hence, they are fully differential. With the exception of the gluon-gluon fusion process, for which a special treatme

We present predictions for the total cross section for the production of a charged Higgs boson in the intermediate-mass range (mH± ∼mt) at the LHC, focusing on a type-II two-Higgs-doublet model. Results are obtained at next-to-leading order (NLO) accuracy in QCD perturbation theory, by studying the full process pp→H±W∓bb¯ in the complex-(top)-mass scheme with massive bottom quarks. Compared to low

We study the production of jets in hadronic collisions, by computing all contributions proportional to α S n α m , with n + m = 2 and n + m = 3. These correspond to leading and next-to-leading order results, respectively, for single-inclusive and dijet observables in a perturbative expansion that includes both QCD and electroweak effects. We discuss issues relevant to the definition of hadronic j

The levels and conformers of alpha-synuclein are critical in the pathogenesis of Parkinson's Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation and secretion have been identified as regulators of alpha-synuclein at different stages of its intracellular trafficking and transcellular propagation. Here we review pathways involved in the removal of various forms of al

Prostate cancer (PCa)is one of the first three causes of cancer mortality in Europe. Screening in asymptomatic men (aged 55–69 yr)using prostate-specific antigen (PSA)is associated with a migration toward lower staged disease and a reduction in cancer-specific mortality. By 20 yr after testing, around 100 men need to be screened to prevent one PCa death. While this ratio is smaller than for breast

Lipid nanodiscs can be used to solubilize functional membrane proteins (MPs) in nativelike environments. Thus, they are promising reagents that have been proven useful to characterize MPs. Both protein and non-protein molecular belts have shown promise to maintain the structural integrity of MPs in lipid nanodiscs. Small-angle neutron scattering (SANS) can be used to determine low-resolution struc