Isolated digesta as an effective and reliable ex vivo system to study the release profile of drug formulations : study on Candida utilis urate oxidase
Many artificial systems simulate the physiological state of the human gastrointestinal tract (GIT) and its separate compartments. These systems have the biorelevant media and imitate the physical forces and transit times of the GIT compartments, however, they lack the food-related and within-compartmental regulations and thus issues with translation of the data obtained to clinics arise. We aimed
