The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infection. To test this hypothesis, we developed a nove

In Developmental Plasticity and Evolution, Mary-Jane West-Eberhard argued that the developmental mechanisms that enable organisms to respond to their environment are fundamental causes of adaptation and diversification. Twenty years after publication of this book, this once so highly controversial claim appears to have been assimilated by a wealth of studies on ‘plasticity-led’ evolution. However,

Furfural is a pivotal renewable platform molecule obtained from the chemical breakdown of hemicellulose. While it has traditionally been valorized to value-added chemicals through catalytic hydrogenation in biorefineries, its direct electrocatalytic hydrogenation presents attractive advantages. This article describes the significant improvements brought by the structuring of copper cathodes applie

Psoriasis, a chronic inflammatory skin disease, goes beyond visible symptoms and affects the general well-being of patients. The aim of this study is to understand how patients with psoriasis perceive their skin characteristics and reactivity to allergens. The study population includes 11,283 participants within the European Dermato-Epidemiology Network (EDEN) Fragrance study, covering several Eur

Metal cutting technology plays an important role in the automotive and aeronautic sectors, both of whichare important for the Swedish economy. Both make use of traditional grey cast iron and difficult-to-machine materials like titanium alloys and compacted graphite iron. The tools used to machine thesematerials wear at varying rates depending on factors such as contact temperature, pressure, and t

Background: Parkinson's disease (PD) is a neurodegenerative disease that leads to progressive disability. Cost studies have mainly explored the early stages of the disease, whereas late-stage patients are underrepresented. Objective: The aim is to evaluate the resource utilization and costs of PD management in people with late-stage disease. Methods: The Care of Late-Stage Parkinsonism (CLaSP) stu

Molybdenum clusters, characterized by their unique structure and intriguing catalytic properties, have gained significant attention in recent years. In several existing studies, density functional theory (DFT) methods have been used to find the lowest energy Mo clusters and explore their electronic and magnetic structure. In all cases, with the exception of a single recent study, where a genetic a

Background: Metastatic breast cancer (MBC) is the main cause of breast cancer-related death. The outcome of MBC varies, and there is a lack of biomarkers to aid in prognostication. The primary aim of this study was to evaluate the prognostic value of gene expression (GEX) signatures in the primary tumor (PT) and distant metastasis (DM) for progression-free survival (PFS) and overall survival (OS).

Methanol steam reforming (MSR) is considered as an effective way to provide on-board hydrogen production technology for fuel cell applications. CuFe1.2Al.8O4 spinel catalyst was synthesized by sol–gel method and the chemical and physical properties were studied in-depth. X-ray diffraction, hydrogen-temperature programmed reduction (H2-TPR), BET, and scanning electron microscopy were used to charac

People often visit natural settings for recreation and psychological restoration. This study aims to improve understanding of how exposure to and experiences of mammalian wildlife in local natural settings can permit and promote recreation and restoration. Randomly sampled residents in three regions of Sweden (N = 303) with varying presence of fear-relevant species (wolf, wild boar) and fear-irrel

Herein is reported an efficient catalytic system for the direct synthesis of styrene carbonate from styrene and CO2. The preparation and characterization of the catalyst using FTIR, TEM, EDX, XPS, and PXRD is presented. The catalyst comprised of nano-silver modified polyoxometalates (Agx/POM) and n-tetra butyl ammonium bromide (TBAB) was employed in the oxidative carboxylation of styrene with CO2

Multinary metal chalcogenides hold considerable promise for high-energy potassium storage due to their numerous redox reactions. However, challenges arise from issues such as volume expansion and sluggish kinetics. Here, a design featuring a layered ternary Bi0.4Sb1.6Te3 anchored on graphene layers as a composite anode, where Bi atoms act as a lattice softening agent on Sb, is presented. Benefitin

This work concerns the design of perfectly conducting objects that are invisible to an incident transverse magnetic plane wave. The object in question is a finite planar waveguide with a finite periodic array of barriers. By optimizing this array, the amplitude of the scattered field is reduced to less than 10-9 times the amplitude of the incident plane wave everywhere outside the waveguide. To ac

There is great interest in measuring immune function in wild animals. Yet, field conditions often have methodological challenges related to handling stress, which can alter physiology. Despite general consensus that immune function is influenced by handling stress, previous studies have provided equivocal results. Furthermore, few studies have focused on long-lived species, which may have differen

Reconfigurable surface (RS) has been shown to be an effective solution for improving wireless communication links in general multi-user multiple-input multiple-output (MU-MIMO) setting. Current research efforts have been largely directed towards the study of reconfigurable intelligent surface (RIS), which corresponds to an RS made of passive reconfigurable elements with only phase shifting capabil

Alloying metals to form intermetallics has been proven effective in tuning the chemical properties of metal-based catalysts. However, intermetallic alloys can undergo structural and chemical transformations under reactive conditions, leading to changes in their catalytic function. Elucidating and understanding these transformations are crucial for establishing relevant structure-performance relati