Apolipoprotein E (ApoE), an important mediator of lipid transportation in plasma and the nervous system, plays a large role in diseases such as atherosclerosis and Alzheimer's. The major allele variants ApoE3 and ApoE4 differ only by one amino acid. However, this difference has major consequences for the physiological behaviour of each variant. In this paper, we follow (i) the initial interaction

BACKGROUND: Postoperative pancreatic fistula is the leading cause of morbidity after distal pancreatectomy. Strategies investigated to reduce the incidence have been disappointing. Recent data showed a reduction in postoperative pancreatic fistula with the use of synthetic mesh reinforcement of the staple line. METHODS: An RCT was conducted between May 2014 and February 2016 at four tertiary refer

Increasingly fine-grained cloud billing creates incentives to review the software execution footprint in virtual environments. For example, virtual execution environments move towards lower overhead: from virtual machines to containers, unikernels, and serverless cloud computing. However, the execution footprint of security components in virtualized environments has either remained the same or eve

Background: A majority of individuals with osteoarthritis (OA) are insufficiently physically active. Self-monitoring with wearable activity trackers (WAT) could promote physical activity (PA), and increased knowledge of PA patterns and adherence to using a WAT is needed. The aim of this study was to describe PA patterns and adherence to WAT-use during an intervention among participants of working

The idea of ‘Sustainability as a Real Utopia’ elaborated on here adapts sociologist Erik Olin Wright’s emancipatory social science and is a heuristic informed by critical realism and social theory for interdisciplinary research on viable alternatives that move society towards achieving sustainability. Starting from the proposition that many environmental problems are rooted in how social structure

Background: Bicuspid aortic valve (BAV), the most common congenital cardiac anomaly, has been associated with an aortopathy, increased aortic stiffness and diastolic dysfunction. The involved mechanisms and impact of age remain unclear. It was the aim of this study to characterize arterial and cardiac function, their correlation, and the effect of age in children and adults with a history of BAV.

Background: After decades of ubiquitous oxygen therapy in all patients with acute myocardial infarction (MI), recent guidelines are more restrictive based on lack of efficacy in contemporary trials evaluating hard clinical outcomes in patients without hypoxemia at baseline. However, no evidence regarding treatment effects on health-related quality of life (HRQoL) exists. In this study, we investig

Non-responders to checkpoint inhibitors generally have low tumor T cell infiltration and could benefit from immunotherapy that activates dendritic cells, with priming of tumor-reactive T cells as a result. Such therapies may be augmented by providing tumor antigen in the form of cancer vaccines. Our aim was to study the effects of mitazalimab (ADC-1013; JNJ-64457107), a human anti-CD40 agonist IgG

Did the different public-health policies that Sweden and Denmark pursued in the beginning of the COVID-19 pandemic result in different levels of public trust in governments’ and health authorities’ ability to guide the two countries safely through the pandemic? How did the level of trust change as the pandemic unfolded? And were there any cross-country differences in the correlates of trust? Using

We study questions of existence and uniqueness of quadrature domains using computational tools from real algebraic geometry. These problems are transformed into questions about the number of solutions to an associated real semi-algebraic system, which is analyzed using the method of real comprehensive triangular decomposition.

Den andra av två artiklar rörande det fängelse, den s k proban, som Lunds universitet hade under den tid lärosätet ägde egen jurisdiktion över anställda och studenter. Denna andra del behandlar studentoroligheter under tidigt 1800-tal, den oklara frågan var proban var placerad under 1800-talet samt några av de sista studenterna att spärras in häri under 1830- och 1840-talen, dels för brott, dels s

The argument and discussion in this paper begins from the premise that Hume was an atheist who denied the religious or theist hypothesis. However, even if it is agreed that that Hume was an atheist this does not tell us where he stood on the question concerning the value of religion. Some atheists, such as Spinoza, have argued that society needs to maintain and preserve a form of “true religion”,

Background: The positive effects of Kangaroo mother care in NICU’s are well documented but, to a lesser extent, explored during inter-hospital neonatal transport. Inter-hospital transport, with the infant placed in a transport incubator, increases the risk of separation while infants in Kangaroo mother care position implies that the parents accompany the transport. There exists limited knowledge i

Vertical III-V nanowire MOSFETs show potential towards the ultimate transistor scaling. A high transconductance and current density are achieved based on the gate-all-around architecture. This work presents a high-frequency design of such devices, achieving more than 600 GHz cut-off frequencies (fT, fmax), at 20 nm gate length. Furthermore, capacitance design and scaling trends, supported by COMSO

Historik över tidningen Lundagård med anledning av dess 100-årsjubileum.

Public sector services are audited, measured and ranked in order to improve quality and transparency and to prompt organizations to conform to normative definitions of quality. In Swedish eldercare, a nationwide user survey distributed by the public authorities to all eldercare users, designed to gauge user satisfaction, is a prominent example of this form of soft governance. The aim of the presen

The propagation of premixed reacting waves can be characterized by a displacement speed Sd at which the local surface of the reaction progress scalar moves respective to flow. Often, Sd is considered through decomposition into three parts of contribution due to the tangential diffusion of curvature, normal diffusion, and reaction. A set of recently derived transport equations for Sd and three of i

The study of a turbulent premixed flame often involves analysing quantities conditioned to different iso-surfaces of a reactive scalar field. Under the influence of turbulence, such a surface is deformed and translated. To track the surface motion, the displacement speed of the scalar field respective to the local flow velocity is widely used and this quantity is currently receiving growing attent