Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a un

The self-identification of Sweden and Canada as exceptionally caring and ethical states committed to the goal of global gender justice has been reinforced through their adoption of feminist foreign policies (FFPs). However, despite the enthusiasm surrounding the potential of feminism as an ethical approach to foreign policy making, critics have drawn attention to the many failings of FFPs that ham

This paper explores the potential of corpus data to account for language users’ mental representations of a high-frequency item that is prone to phonetic reduction. We present an analysis of the realisations of semi-modal have to in spoken American English, which is a candidate for to-contraction (compare wanna and gotta) but has no clearly established contracted form. The study therefore focussesThis paper explores the potential of corpus data to account for language users’ mental representations of a high-frequency item that is prone to phonetic reduction. We present an analysis of the realisations of semi-modal have to in spoken American English, which is a candidate for to-contraction (compare wanna and gotta) but has no clearly established contracted form. The study therefore focusses

This paper addresses the issue of coalescence of frequent collocations and its consequences for their realization and mental representation. The items examined are ‘semi-modal’ instantiations of the type V-to-Vinf, namely have to, used to, trying to and need to, in American English. We explore and compare their realization variants in speech, considering the effects of speech-internal and extra-liThis paper addresses the issue of coalescence of frequent collocations and its consequences for their realization and mental representation. The items examined are ‘semi-modal’ instantiations of the type V-to-Vinf, namely have to, used to, trying to and need to, in American English. We explore and compare their realization variants in speech, considering the effects of speech-internal and extra-li

Catalytic processes are present in a wide range of aspects, from fundamental biological processes to modern chemical synthesis. In practical terms, catalysis has thrived as a rapidly growing industry. However, a significant gap in our understanding of catalytic processes exists between the molecular and industrial scales, arising from the complexity at the nano- and micro-levels of catalytic nanop

Twenty-five years since foundational publications on valuing ecosystem services for human well-being1,2, addressing the global biodiversity crisis3 still implies confronting barriers to incorporating nature’s diverse values into decision-making. These barriers include powerful interests supported by current norms and legal rules such as property rights, which determine whose values and which value

Both advocates and critics of deliberative theory have regarded power relations as problems for public deliberation. Three aspects—interests, ideology and status differences—have been thought to distort deliberative processes. This article discusses a growing body of case studies that indicate that these “problems” may actually, under certain conditions, help facilitate inclusion and equality in d

Cooperation between movements and political elites are frequently associated with the risk of cooptation. Because it undercuts contentious actors, cooptation may seem rational for elites that seek to protect their interests. However, recent scholarship questions whether this view is empirically valid. Adding to these debates, this article demonstrates that even if we accept, for the sake of argume

Policies on preventing radicalization and recruitment to violent Islamist organizations have been widely criticized for reinforcing negative stereotypes of Muslims as a group. Sweden has stood out by international comparison by announcing an approach built on inclusion and participation, especially with regard to Muslim civil society. But what does it mean to make a policy process inclusive and pa

What difference can local participation make in a world where inequality increases everywhere, where segregation pulls communities apart and where policymakers marginalise the needs and interests of the people whose lives their decisions affect the most? This question was central two decades ago when research on participatory institutions took off. Leftist scholars described participatory budgetinWhat difference can local participation make in a world where inequality increases everywhere, where segregation pulls communities apart and where policymakers marginalise the needs and interests of the people whose lives their decisions affect the most? This question was central two decades ago when research on participatory institutions took off. Leftist scholars described participatory budgetin

What should count as legitimate forms of reasoning in public deliberation is a contested issue. Democratic theorists have argued that storytelling may offer a more accessible form of deliberation for marginalised citizens than ‘rational argumentation’. We investigate the empirical support for this claim by examining Swedish citizens’ use of storytelling in written communication with the political

Local political leaders as well as international organizations have embraced participatory budgeting in response to problems of political exclusion and citizens’ dissatisfaction with representative democracy. This article provides a framework to highlight important aspects of the politics of participation. The framework allows scholars to explore how factors external to spaces of participation intLocal political leaders as well as international organizations have embraced participatory budgeting in response to problems of political exclusion and citizens’ dissatisfaction with representative democracy. This article provides a framework to highlight important aspects of the politics of participation. The framework allows scholars to explore how factors external to spaces of participation int

Rural perspectives in political debates are often dismissed as sentimental, narrowly self-interested, and irrational. This paper reports findings that challenge this view. Applying a deliberative systems approach, it examines how rural perspectives are articulated in Swedish public discourse. It identifies four coherent discourses that promote distinct political values: economic growth, rural cons

Efterskrift till Peterr Lucas Erixons samlade dikter

Background The underlying mechanisms of thrombosis in Lemierre's syndrome and other septic thrombophlebitis are incompletely understood. Therefore, in this case-control study we aimed to generate hypotheses on its pathogenesis by studying the plasma proteome in patients with these conditions. Methods All patients with Lemierre's syndrome in the Skåne Region, Sweden were enrolled prospectively duri

The important bacterial pathogen Streptococcus pyogenes secretes IdeS (immunoglobulin G-degrading enzyme of S. pyogenes), a proteinase that cleaves human immunoglobulin G (IgG) antibodies in the hinge region resulting in Fc (fragment crystallizable) and F(ab')2 (fragment antigen-binding) fragments and protects the bacteria against phagocytic killing. Experiments with radiolabeled IdeS and flow cyt

Oncogene-induced senescence (OIS) is a persistent anti-proliferative response that acts as a barrier against malignant transformation. During OIS, cells undergo dynamic remodeling, which involves alterations in protein and organelle homeostasis through autophagy. Here, we show that ribosomes are selectively targeted for degradation by autophagy during OIS. By characterizing senescence-dependent al