Hormone-sensitive lipase (HSL), a key enzyme in fatty acid mobilization from lipid stores, is expressed in the liver and decreased hepatic insulin sensitivity has been reported in our HSL null mouse model. Here, an integrated approach, comprising transcriptomics and proteomics together with targeted metabolite analysis, was used to investigate the liver phenotype of HSL null mice. Oligonucleotide

The damage caused by a dramatic worldwide increase in so-called natural disasters is staggering, with the poor in developing countries being most at risk. This paper analyses: (a) the key variables and their causal relations that underlie the complex system of risk and disaster occurrence in slums; (b) the impacts of disasters on slums; (c) the strategies used by local people to cope with risk and

Anterior cruciate ligament (ACL) injury is associated with mechanical instability and defective neuromuscular function, and can lead to further injury, increased joint loading and osteoarthritis. Patients with ACL injury demonstrate altered postural orientation, manifested as observable "substitution patterns" (SPs) but no one has applied a clinically useful method to systematically study postural

OBJECTIVES: To investigate the effect of human T-lymphotropic virus type 1 (HTLV-1) on CD4 counts and mortality in tuberculosis (TB) patients with or without human immunodeficiency virus (HIV). METHODS: A prospective study on 280 hospitalized patients with pulmonary TB was performed in Guinea-Bissau, 1994-1997, including HIV, CD4 counts and clinical outcome. We compared the CD4 count levels at the

Spherical particles with known properties were used to demonstrate and test a novel software package known as AASIFIT, which is able to unfold complex alpha spectra. A unique feature of the program is that it uses simulated peak shapes in the fitting process. The experimental reference particles in the testing were artificially produced U particles of diameter 1.4mum and a nuclear bomb particle wi

BACKGROUND: In total knee replacement, sound early fixation of the prosthesis is crucial for achieving a good long-term result and for minimising the risk of loosening. Various types of prosthetic material, different surface textures and shapes and the incorporation of screws or pegs have been used to achieve good fixation, particularly in the uncemented knee. Hydroxyapatite (HA) coating of prosth

AIMS/HYPOTHESIS: Impaired glucose tolerance and impaired insulin secretion have been reported in families with PAX6 mutations and it is suggested that they result from defective proinsulin processing due to lack of prohormone convertase 1/3, encoded by PCSK1. We investigated whether a common PAX6 variant would mimic these findings and explored in detail its effect on islet function in man. METHODS

Coals with similar thermal maturity and from the same deposit normally show a considerable range in petroleum generation potential as measured by the Hydrogen Index (HI). This variation may partly be related to variations in plant input to the precursor mires and organic matter preservation. It is widely accepted that some Cenozoic coals and coaly sediments have the potential to generate oil, whic

Psykiska sjukdomar är ett globalt problem och räknas idag som ett av de stora folkhälsoproblemen. Idag lever 38,2% av Europas befolkning med psykisk ohälsa och det är inte bara personen med psykisk sjukdom som berörs utan även personens närstående. Studien genomfördes som en litteraturstudie vars syfte var att ta del av den forskning som har undersökt närståendes erfarenheter av den psykiatriska s

This study aims to enrich the understanding of the cultural dimension of open innovation (OI) collaboration between business and academia by focusing on challenges and how professionals build trust with universities to overcome them. It examines collaborative OI activities between IBM and universities in the Nordic region. We see the need to study this issue as the cultural aspect is an underexplo

Människors köpmönster ändras i takt med att digitala lösningar blir en allt mer integrerad del i deras vardag. Det blir allt lättare att hitta produktinformation och inköp kan utföras var som helst. Denna förändring är lätt att se inom de flesta delar av detaljhandeln, men inom livsmedelsbranschen är förändringen inte lika tydlig. Syftet med detta examensarbete var att genomföra en analys av köpmAs digital solutions become a more integrated part of peoples’ everyday life, their purchasing patterns are changing. Today it is easier to research products and purchases can be performed anytime, anywhere. The change is apparent in most retail sectors but not as much in the fast moving consumer goods sector. By using a user-centred approach this master thesis aim to analyse the user behaviour wi

Strandskydd i Svedala kommun Strandskyddet är, tillsammans med det generella biotopskyddet, det enda direkt gällande skyddet för stränder i Sverige. Generellt strandskydd har funnits i Sverige sedan 1975, och i många kommuner är strandskyddet utvidgat. Svedala kommun har utvidgat strandskydd runt sju av sjöarna i kommunen. Syftet med strandskyddet är att säkerställa allmänhetens tillgång till strShoreline protection is, along with general habitat protection, the only directly applicable conservation act for shorelines in Sweden. The purpose of shoreline protection is to safeguard the public’s recreational access to shoreline areas and protect flora and fauna. Sweden has had general shoreline protection since 1975, and in many municipalities the shoreline protection is extended. Svedala mu

Yrkesrelaterad stress uppkommer när ansträngning av psykologiska eller fysiska egenskaper går utöver individens förmåga. I föreliggande studie beskrivs konsekvenser av yrkesrelaterad stress hos sjuksköterskor som arbetar på avdelning. Yrkesrelaterad stress hos sjuksköterskor är ett vanligt förekommande fenomen på sjukhusavdelningar. Syftet med studien var att identifiera konsekvenser av sjuksköter

Utsläpp av kväve i naturen är ett stort problem eftersom det till exempel kan bidra till övergödning och så kallade döda bottnar i sjöar i akvatiska och marina miljöer. Förmågan att kunna avlägsna kväve från avloppsvatten har därför blivit ett viktigt medel för att bevara och skydda miljön. Kväveavskiljning från kommunala avloppsvatten sker vanligtvis med hjälp av nitrifikation och denitrifikationEmissions of reactive nitrogen to the environment is of major concern, e.g. since it is known to contribute to eutrophication and dead sea floors in water bodies. The capability to remove nitrogen from wastewater has therefore become a critical means of preserving and protecting the environment. Conventional nitrogen removal from municipal wastewaters usually includes nitrification together with d

Syftet med denna studie är att undersöka vilka aspekter elever i årskurs tre behöver uppmärksammas på för att kunna sjunga starkt och svagt. Syftet är också att för läraren utveckla kunskaper om praxisnära forskning. Undersökningens metod är kvalitativ då den bygger på modellen learning study med variationsteorin som teoretisk utgångspunkt. Det empiriska materialet består av sammanlagt sex filmadeThe purpose of this study is to examine which aspects students in year three in the Swedish comprehensive school need to pay special attention to in order to alternate between loudly and softly singing. The aim is also for the teacher to develop knowledge of practice oriented research. The survey methodology is qualitative as it is based on the model learning study with variation theory as the the

Allt vi ser är uppbyggt av små partiklar som vi kallar atomer. Men atomerna är inte fundamentala, de består av ännu mindre partiklar och faktiskt, är de mesta av dem tomrum. En atom har liknande struktur som vårt solsystem, det finns en mycket tung kärna i mitten (solen) och lättare elektroner som kretsar runt den (planeterna). Mellan kärnan och elektronerna finns mestadels tomrum, precis som i våWe study a 1+1 dimensional Yang-Mills model in the light-cone gauge (the ’t Hooft model). The colour group is SU (N ) and we study the limit N → ∞, the limit is taken such that g²N is kept constant. In this limit the only contributing diagrams are planar diagrams without gluon-gluon interactions. Using this, it is shown that there are no free quarks in this model. The bound state wave equation is

The aim of this studie was to examine how self-identified pedophiles describes pedophilia, and it´s linkage to child sexual abuse, on their blogs. There are currenty limited research on self-identified pedophiles, which means that pedophiles outside clinical- and criminal settings are not being represented in the avalible research. Theese individuals are valuable for the research of pedophilia, be

Within the software industry it is now common to use the freemium business model; giving away the core product for free while charging for additional premium features. A risk for companies adopting the freemium business model is that the percentage of paying customers is not high enough to both subsidize all the free users and make profit for the company. This thesis investigates how the design o