Cell death–inducing DNA fragmentation factor-like effector C (CIDEC) expression in adipose tissue positively correlates with insulin sensitivity in obese humans. Further, E186X, a single-nucleotide CIDEC variant is associated with lipodystrophy, hypertriglyceridemia, and insulin resistance. To establish the unknown mechanistic link between CIDEC and maintenance of systemic glucose homeostasis, we

PURPOSE: Knowledge of how blood perfusion is affected during and after reconstructive surgery is of great importance to predict the survival of grafts and flaps. When commonly used reconstructive procedures were developed a century ago, they were based on empirical observations of clinical outcome.METHODS: This is a comprehensive literature review that summarizes the current state of knowledge reg

We present a novel method, to our knowledge, to control the shape of the spectra using 2-beam hybrid femtosecond (fs)/nanosecond (ns) coherent anti-Stokes Raman scattering (RCARS). The method is demonstrated experimentally and theoretically by utilizing a species-selective excitation approach via a field-free molecular alignment as an illustrative example. Two non-resonant fs laser pulses with pro

Background: Eating disorders (ED) are severe psychiatric conditions, characterized by decreased quality of life and high mortality. However, only a minority of patients with ED seek care and very few receive treatment. Internet-delivered cognitive behavioral therapy (ICBT) has the potential to increase access to evidence-based treatments. Aims: The aims of the present study were to (1) develop and

We analyzed the morphology and the transcriptomic changes of human neural stem progenitor cells (hNSPCs) grown on laminin in adherent culture conditions and subjected to simulated microgravity for different times in a random positioning machine apparatus. Low-cell-density cultures exposed to simulated microgravity for 24 h showed cell aggregate formation and significant modulation of several genes

First Published in 1991. This is Volume 13 in a series of Transportation Studies. It contains 2 parts of the proceedings of a Conference held at Stockholmsmassan, Alvsjo, Sweden, 21-24 May 1989, organized by the Swedish Board of Transport in co-operation with the Department of Traffic Planning and Engineering, Lund Institute of Technology.

The role of public transport in society is crucial, particularly for those who do not have access to alternative transport modes. For public transport to be able to fulfil its societal role, it should not be perceived as unsafe or unhealthy by its (potential) users. Several studies from all over the world have shown that anxiety has increased remarkably during the pandemic, and it is likely to las

Interferon gamma (IFNγ) is central to the inflammatory immune response, such as that entrained by BCG immunotherapy for bladder cancer. However, immune-mediated tumour cell killing is subject to modulation by immunoinhibitory “checkpoint” receptors such as PD-L1. We investigated the effects of IFNγ on barrier-forming in vitro-differentiated normal human urothelium using mRNA-sequencing, and showed

Background: Approximately 180 mothers are treated in Swedish Intensive Care Units (ICU) due to preeclampsia each year. Although several clinical risk factors are known, prediction of critical disease is challenging. Two scavenger proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) have been suggested to be associated with the oxidative stress seen in preeclampsia. The ratio of two other biom

En vägledning i att lära sig grunderna i att arbeta med Trisotech Enterprise Suite för att utforma arbetsflöden i BPMN med beslutspunkter som modelleras i DMN. Syftet är att utforma modeller och lösningar för strukturerat och automatiserat beslutsfattande i verksamhetsprocesser.

In past years, Sweden has been facing a rapid growth of photovoltaic cells, and the total PV installation capacity increased from 300 kW to 1090 MW (2006–2020). The increased number of PV users was a result of active support from the Swedish government with an aim of achieving multiple sustainable goals regarding renewable energy. This project evaluates the profitability of shared PV systems in co

Neonicotinoid insecticides applied to flowering crops can have negative impacts on bees, with implications for crop pollination. To assess if exposure to the neonicotinoid clothianidin via a treated crop (rapeseed) affected bee behaviour, pollination performance (to strawberry), and bee reproduction, we provided each of 12 outdoor cages with rapeseed (autumn-sown plants complemented with a few spr

Background: The risk of adults with a congenital heart defect (ACHD) developing heart failure, stroke, arrhythmias, and the need for valve replacement is increased compared to healthy peers. Evidence for the use of novel oral anticoagulants (NOAC) in this patient group is still lacking and vitamin K antagonists (VKA) are the primary choice for patients with a mechanical valve. The present aim was

Background and aims: Concerns regarding adverse events associated with the use of acid suppressants have increased. However, the impact of proton pump inhibitors (PPIs) and histamine‐2 receptor antagonists (H2RAs) on the risk of atherosclerotic cardiovascular disease (ASCVD) remains unknown. This study aimed to estimate the risk of ASCVD in association with the use of PPIs and H2RAs. Methods: This

A common issue affecting DNA methylation analysis in tumor tissue is the presence of a substantial amount of non-tumor methylation signal derived from the surrounding microenvironment. Although approaches for quantifying and correcting for the infiltration component have been proposed previously, we believe these have not fully addressed the issue in a comprehensive and universally applicable way.

Ultrasound optical tomography (UOT) is a hybrid imaging modality based on interaction between ultrasound and light, with a potential to extend optical imaging capabilities in biological tissues to depths of several centimeters. Several methods have been developed to detect the UOT signal. To better understand their potential for deep tissue imaging, we present a theoretical contrast-to-noise compa

When people are conversing, a key non-verbal aspect of communication is the direction in which the participants are looking, as this may convey where each person’s attention is focused. In a programming context, for instance an integrated development environment (IDE), the interaction design frequentlydirects the programmer’s gaze towards specific locations on-screen. For example, syntax highlight

The Keccak sponge function family, designed by Bertoni et al. in 2007, was selected by the U.S. National Institute of Standards and Technology (NIST) in 2012 as the next generation of Secure Hash Algorithm (SHA-3). Due to its theoretical and practical importance, cryptanalysis of SHA-3 has attracted a lot of attention. Currently, the most powerful collision attack on SHA-3 is Jian Guo et al.’s lin

In this work, we study self-supervised representation learning for 3D skeleton-based action recognition. We extend Bootstrap Your Own Latent (BYOL) for representation learning on skeleton sequence data and propose a new data augmentation strategy including two asymmetric transformation pipelines. We also introduce a multi-viewpoint sampling method that leverages multiple viewing angles of the same