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The tumour microenvironment is programmed by cancer cells and substantially influences anti-tumour immune responses1,2. Within the tumour microenvironment, CD8+ T cells undergo full effector differentiation and acquire cytotoxic anti-tumour functions in specialized niches3–7. Although interactions with type 1 conventional dendritic cells have been implicated in this process3–5,8–10, the underlying
Introduction Delayed palliative management (DPM) is an alternative for prostate cancer (PCa) patients with poor performance status, or those who received radical treatment but progressed and no longer meet the criteria for curative treatment. PIONEER is a large network of federated data analytic platforms in PCa that aims to improve its care through the application of big data analytics. The objec
Horizontal gene transfer is one of the most important drivers of bacterial evolution. Transformation by uptake of extracellular DNA is traditionally not considered to be an effective mode of gene acquisition, simply because extracellular DNA is degraded in a matter of days when it is suspended in e.g. seawater. Recently the age span of stored DNA was increased to at least 2 Ma. Here, we show that
This article explores the representation of the female image in the visual artwork of generative AI and the gender issues in it, using eight different generative AI systems, ERNIE-ViLG 2.0, Shuhua, and Yihui from China and Nightcafe, Fotor, Jasper Art, DALLE and Deep dream generator from the West, as comparative cases. In this paper, female cyborg is selected as a representative of female images,
BACKGROUND Advanced Therapy Medicinal Products (ATMPs) for human use have advanced globally with the rapid adoption of Chimeric Antigen Receptor T-cell (CAR-T) therapies in haemato-oncology. CAR-T cell therapy and ATMPs have unique, significant acute and chronic toxicities, and appropriate patient care is crucial. Significant challenges, including the need for nurse education and training, accompa
Background: Stroke is one of the major chronic non-communicable diseases (NCDs) with high morbidity, disability and mortality. The key to preventing stroke lies in controlling risk factors. However, screening risk factors and quantifying stroke risk levels remain challenging. Methods: A novel prediction model for stroke risk based on two-level feature selection and deep fusion network (SRPNet) is
Women have made substantial gains in education in recent decades and outperformmen in educational attainment across the OECD, but the consequences of this reversal of the gender gap in education (RGE) have not been well researched. In this study, we address the association between the RGE and partnering, employment, and support for a right-wing populist party in Sweden. Of note, we explore the dif
Women have made substantial gains in education and outperform men regarding educational attainment across the OECD, but the consequences of this reversal of the gender gap in education (RGE) have not been well researched. We address the association between the RGE and partnering, employment, and support for a right-wing populist party in Sweden. We explore the differential impacts of women's educa
Politiska ledningar runtom i Europa måste agera bestämt när något land helt eller delvis försöker dra sig undan finansieringen av kollektiva varor, skriver Jerker Holm, professor vid ekonomihögskolan, Lunds universitet.
Abstract:Background:Chronic postoperative inguinal pain (CPIP) affecting daily activities is reported in 8-12% and moresevere pain between 0.6-6% after inguinal hernia repair. CPIP incidences are based on a variety ofPROMs and definitions of pain, making comparison between studies difficult. Pain during sexualactivity (SEX-P) is rarely studied in randomized settings. Few RCTs with large cohorts re
Stress is a public health concern. One of the explanations to why women, more than men, receive stress-related diagnosis in connection to sickness absence is their responsibility for housework and caregiving. We investigate men’s and women’s time allocation and its association with everyday stress across life course stages (25-74 years), using individual time diary data (N=11,880) from the 2000/01
BackgroundDiet has been hypothesized as a risk factor for the development of inflammatory bowel disease (IBD).ObjectiveThe objective of this study was to explore associations between maternal diet diversity and quality in pregnancy and the offspring’s risk of IBD.MethodsWe used data from a nationwide cohort study on 85,129 Norwegian children followed from birth (1999–2009) with information on mate
