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Vitamin D, PTH, and calcium and the risk of prostate cancer: a prospective nested case-control study.

OBJECTIVE: To examine the risk of prostate cancer in relation to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH, and calcium. METHODS: Nine hundred forty-three incident prostate cancer cases were identified in the Malmö Diet and Cancer Study cohort, and each was matched with one control using incidence density matching with age as the underlying timescale. We also matche

Activity-based accounts of mechanism and the threat of polygenic effects

Accounts of ontic explanation have often been devised so as to provide an understanding of mechanism and of causation. Ontic accounts differ quite radically in their ontologies, and one of the latest additions to this tradition proposed by Peter Machamer, Lindley Darden and Carl Craver reintroduces the concept of activity. In this paper I ask whether this influential and activity-based account of

Travel behaviour of online shoppers in Sweden

Online shopping opportunities are transforming travel behaviour for shopping and could potentially reduce the overall travel demand. Despite numerous studies on online shopping, only a few have taken an approach that includes trips for all travel purposes. Based on a web-survey, this paper provides results on travel behaviour for physical shopping for frequent, regular, and infrequent online shopp

Discourse or Merely Noise? Regarding the Disagreement on Undocumented Migrants

Drawing on Jacques Ranciere's theorising of the political, this article analyses the disagreement on undocumented migrants in recent legislation in Sweden and within the European Union as well as in Swedish labour union practice. Both the consensus understanding of the issue of undocumented migrants and the materialisation of dissensus through the political activities of undocumented migrants are

Detection of flow direction in high-flying insect and songbird migrants

Goal-oriented migrants travelling through the sea or air must cope with the effect of cross-flows during their journeys if they are to reach their destination [1–3] . In order to counteract flow-induced drift from their preferred course, migrants must detect the mean flow direction, and integrate this information with output from their internal compass, to compensate for the deflection. Animals ca

Formation of long single quantum dots in high quality InSb nanowires grown by molecular beam epitaxy

We report on realization and transport spectroscopy study of single quantum dots (QDs) made from InSb nanowires grown by molecular beam epitaxy (MBE). The nanowires employed are 50-80 nm in diameter and the QDs are defined in the nanowires between the source and drain contacts on a Si/SiO2 substrate. We show that highly tunable QD devices can be realized with the MBE-grown InSb nanowires and the g

The APC-PCI concentration as an early marker of activation of blood coagulation A study of women on combined oral contraceptives

Background: The risk of venous tromboembolism (VTE) in women taking combined oral contraceptives (COCs) is attributed to changes in coagulation and fibrinolysis. The impact of the COCs may be greater in women with preexisting thrombophilic defects. Nevertheless most women who suffer from venous thrombosis do not have any of the well known hereditary or acquired risk factors. A simple and sensitive

A Fast Crank Angle Resolved Zero-Dimensional NOx Model Implemented on a Field-Programmable Gate Array

In the automotive industry, the piezo-based in-cylinder pressure sensor is getting commercialized and used in production vehicles. For example, the pressure sensor offers the opportunity to design algorithms for estimation of engine emissions, such as soot and NO, during a combustion cycle. In this paper a zero-dimensional NO model for a diesel engine is implemented that will be used in real time.

Simplified citrate anticoagulation for CRRT without calcium replacement.

Since 2012 citrate anticoagulation is the recommended anticoagulation strategy for CRRT. The main drawback using citrate compared with heparin as anticoagulant is the need for calcium replacement and the rigorous control of calcium levels. This study investigated the possibility to achieve anticoagulation while eliminating the need for calcium replacement. This was successfully achieved by includi

Four new Caloplaca species (Teloschistaceae, Ascomycotina)

Four new species of the genus Caloplaca, C. kiewkaensis L.S. Yakovczenko, I.A. Galanina & S.Y. Kondr., C. letrouitioides S.Y. Kondr., Elix & Kärnefelt, C. trassii I.A. Galanina & S.Y. Kondr., and C. ussuriensis Oxner, S.Y. Kondr. & Elix from Asia and Australia are described as new to science and compared with closely related species.

Increasing energy coupling into plasma waves by tailoring the laser radial focal spot distribution in a laser wakefield accelerator

By controlling the focal spot quality with a deformable mirror, we are able to show that increasing the fraction of pulse energy contained within the central part of the focal spot, while keeping the total energy and central spot size constant, significantly increases the amount of energy transferred to the wakefield: Our measurements show that the laser loses significantly more laser energy and u

Acute Ultraviolet Radiation Perturbs Epithelialization but not the Biomechanical Strength of Full-thickness Cutaneous Wounds.

We hypothesized that priming of the skin with ultraviolet radiation (UVR) before being injured would enhance wound healing. Four groups, each comprising 20 immunocompetent hairless mice, were exposed to simulated solar irradiation in escalating UVR doses; 0 SED (standard erythema dose) = control, 1 SED, 3 SED and 5 SED. Twenty-four h after UV irradiation, inflammation was quantified by skin reflec

Absorbed Doses and Risk Estimates of (211)At-MX35 F(ab')2 in Intraperitoneal Therapy of Ovarian Cancer Patients.

Purpose: Ovarian cancer is often diagnosed at an advanced stage with dissemination in the peritoneal cavity. Most patients achieve clinical remission after surgery and chemotherapy, but approximately 70% eventually experience recurrence, usually in the peritoneal cavity. To prevent recurrence, intraperitoneal (i.p.) targeted a therapy has been proposed as an adjuvant treatment for minimal residual

Risk of acute myeloid leukemia and myelodysplastic syndromes after multiple myeloma and its precursor disease (MGUS)

Using population-based data from Sweden, we identified all multiple myeloma (MM) patients (n = 8740) and 5652 monoclonal gammopathy of undetermined significance (MGUS) patients diagnosed between 1986 and 2005. We calculated standardized incidence rates (SIRs) for all subsequent hematologic and nonhematologic malignancies for MM patients diagnosed before/after 1995 (introduction of high-dose melpha

Increased Ethanol Productivity in Xylose-Utilizing Saccharomyces cerevisiae via a Randomly Mutagenized Xylose Reductase

Baker's yeast (Saccharomyces cerevisiae) has been genetically engineered to ferment the pentose sugar xylose present in lignocellulose biomass. One of the reactions controlling the rate of xylose utilization is catalyzed by xylose reductase (XR). In particular, the cofactor specificity of XR is not optimized with respect to the downstream pathway, and the reaction rate is insufficient for high xyl

Many-body interactions between particles in a polydisperse polymer fluid

We use a continuum chain model and develop an analytical theory for the interaction between many spheres immersed in a fluid of ideal polydisperse polymers. Assuming local spherical symmetry of the polymer field about each particle, combined with a local approximation, compact expressions are derived for the many-body interaction between the spheres. We use a mean-field approximation to investigat