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BACKGROUND: Phosphatidylethanol (PEth) is an abnormal phospholipid formed in mammalian cells that have been exposed to ethanol. It has been suggested that PEth mediates some of the damaging effects of ethanol on cells. This study was performed to investigate the level of PEth in organs of rats after in vivo alcohol exposure. METHODS: Three exposure models were studied: (1) acute, intraperitoneal i
Sera from 79 patients with acute self-limiting hepatitis, 17 patients with acute hepatitis B evolving into chronic HBsAg carriership, and 43 chronic HBsAg carriers without a history of acute hepatitis were analyzed for presence of hepatitis B virus (HBV)-DNA by a molecular hybridization technique. In acute self-limiting hepatitis, HBV-DNA was cleared within a few weeks after the onset of clinical
Antimicrobial peptides are important effectors of the innate immune system. These peptides belong to a multifunctional group of molecules that apart from their antibacterial activities also interact with mammalian cells and glycosaminoglycans and control chemotaxis, apoptosis, and angiogenesis. Here we demonstrate a novel antimicrobial activity of the heparin-binding and cell-binding domain 5 of h
Objective. Fibrotic skin changes in systemic sclerosis (SSc) are preceded by the appearance of an inflammatory infiltrate rich in T cells. Since no direct comparison with T cells in normal skin has been performed previously, this study was undertaken to functionally characterize T cells in the skin of patients with early active SSc and in normal skin. Methods. We characterized coreceptor expressio
Traditional ice sheet reconstructions have suggested two distinctly different ice sheet regimes along the East Greenland continental margin during the Last Glacial Maximum (LGM): ice to the shelf break south of Scoresby Sund and ice extending no further than to the inner shelf at and north of Scoresby Sund. We report new Be-10 ages from erratic boulders perched at 250 m a.s.l. on the Kap Brewster
The objective of the study was to evaluate the effect of denervation and alpha-ketoglutarate (AKG) administration on the development of osteopenia in the turkey radius. At 22 d of age, all turkeys were subjected to neurectomy of the right radius. Control turkeys were given a saline solution into the crop each day for 97 d. Experimental turkeys were given 0.4 g of AKG/kg of BW into the crop each da
A number of Extremely Large Telescopes for visual-infrared and adjacent wavelengths are in various degrees of progress. All have primary mirrors with equivalent diameters larger than 20 m and are intended for operation with adaptive optics systems. We discuss several ELT observing parameters as functions of wavelength. Stellar energy distributions and atomic line spectra are inspected as are the t
The aim of this study was to explore possible regional differences in the use of coercion in psychiatric care as experienced by patients and relatives. At four psychiatric care settings in different parts of Sweden, 138 committed and 144 voluntarily admitted patients were interviewed at admission using the Nordic Admission Interview. At discharge or, if the care episode was still ongoing, after 3
The study describes extraction of extracellular polymeric substances (EPS) from sewage sludge by applying enzymes and enzymes combined with sodium tripolyphosphate (STPP). Additionally, a systematic study of two non-enzymatic extraction agents is described. The assessment of the released products is made by colorimetrical methods and polysaccharides/glycoconjugates identification by the interactio
Abstract in German Bei 26 Patienten, die wegen eines Wilms-Tumors operiert wurden, wurden genetische Analysen durchgeführt. Bei 13 Kindern wurden klonal erworbene Chromosomenaberrationen gefunden, bei einem eine konstitutionelle Trisomie 18 als einzige Veränderung. Die Chromosomenzahl war bei 13 Patienten verändert. Numerische Veränderungen wurden bei 16 Kindern beobachtet und ein Bruch des ChromoIn 26 consecutive patients operated for Wilms' tumour samples from the tumour were genetically analyzed. Clonal acquired chromosome aberrations were found in 13 patients and a constitutional trisomy 18 as the sole change in 1. The chromosome number was altered in 13 patients. Numerical changes occurred in 16 patients and breakpoint of chromosome 1 in 6 patients. There was no structural alteration
Lithostratigraphy and chronostratigraphy of samples from 18 deep boreholes in Vendsyssel have resulted in new insight into the Late Weichselian glaciation history of northern Denmark. Prior to the Late Weichselian Main advance c. 23-21 kyr BP, Vendsyssel was part of an ice-dammed lake where the Ribjerg Formation was deposited c. 27-23 kyr BP. The timing of the Late Weichselian deglaciation is well
Pediobius sasae sp. nov. ( Hymenoptera: Eulophidae) is described from Japan. This new species belongs to the "eubius-complex" of species and is compared to the species of that group. It was reared from galls induced by an unidentified gall midge of the tribe Oligotrophini ( Diptera: Cecidomyiidae). The galls are formed on stems of dwarf bamboo (Sasa nipponica). Pediobius sasae is a solitary primar
Atomic spectroscopy plays an important role in fusion research and extensive knowledge of atomic parameters is needed for plasma diagnostics. However, a magnetically confined hot plasma can be considered as a spectroscopic fight source which has some unique properties, including high temperature and low density. Fusion devices can therefore be used to tackle problems in basic atomic physics. This
It has been suggested that a single photon can interfere with itself even if the difference between the two paths in the interferometer is larger than the “length” of the photon [Kessel’ and Moiseev, JETP Lett. 58, 81 (1993)]. The interference is regained by detecting the photons using a photon-echo process, where the absorbing atoms will, effectively, act as narrow-band filters. Such an experimen
The aim of this study was to determine MRI findings in patients successfully operated upon for lumbar disc herniation. We investigated 20 patients with a successful outcome after L4-5 or L5-S1 disc operations clinically and with MRI preoperatively, and at 5 days, 6 weeks, and 4 months after surgery. Postoperatively, T1- and T2-weighted images were obtained. At 4 months gadolinium-enhanced images w
The 999del5 mutation is the single, strong BRCA2 founder mutation in Iceland and the most common BRCA1/2 founder mutation in Finland. To evaluate the origin and time since spreading of the 999del5 mutation in Iceland and in Finland, we constructed haplotypes with polymorphic markers within and flanking the BRCA2 gene in a set of 18 Icelandic and 10 Finnish 999del5 breast cancer families. All Icela
