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HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study

OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA).RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feed

Structural and microstructural thalamocortical network disruption in sporadic behavioural variant frontotemporal dementia

Background: Using multi-block methods we combined multimodal neuroimaging metrics of thalamic morphology, thalamic white matter tract diffusion metrics, and cortical thickness to examine changes in behavioural variant frontotemporal dementia. (bvFTD). Method: Twenty-three patients with sporadic bvFTD and 24 healthy controls underwent structural and diffusion MRI scans. Clinical severity was assess

Mental distress in relation to police reporting among adolescent victims of robbery : A population-based study in southern Sweden

•Robberies as well as mental distress have increased among adolescents in Sweden.•This study on school students in southern Sweden was population-based with a high response rate.•Half of the robbed adolescents abstained from police reporting.•Non-reporters had poorer mental health than victims who reported the robbery.•Non-reporters were also an overall more disadvantaged group.

Burning a holy book: the dilemma of free speech

In recent weeks, Sweden has experienced several Quran-burning incidents. These can reinforce anti-religious discourse and politicised campaigns against religious minorities. They can also put Swedish multicultural harmony at risk. Azher Hameed Qamar argues that we must interpret the laws permitting Quran-burnings as being in the best interest of the people

gatukonst

Definition of street art for The National Encyclopedia of Sweden.

Definitive aetiology of unexplained syncope after cardiovascular autonomic tests in a tertiary syncope unit

BACKGROUND AND AIM: Syncope is a common condition with many possible causes, ranging from benign to life-threatening aetiologies. Establishing a diagnosis can be difficult and specialized syncope units, using cardiovascular autonomic tests (CAT) including head-up tilt test can increase the diagnostic yield. However, up to one fifth of examined patients have inconclusive CAT results. The aim of the

A Systematic Review of Mesenchymal Epithelial Transition Factor (MET) and Its Impact in the Development and Treatment of Non-Small-Cell Lung Cancer.

Lung cancer represents the leading cause of annual cancer-related deaths worldwide, accounting for 12.9%. The available treatment options for patients who experience disease progression remain limited. Targeted therapeutic approaches are promising but further understanding of the role of genetic alterations in tumorigenesis is imperative. The MET gene has garnered great interest in this regard. Th

Theoretical and Practical Aspects of Space-Time DG-SEM Implementations

We discuss two approaches for the formulation and implementation of space-time discontinuous Galerkin spectral element methods (DG-SEM). In one, time is treated as an additional coordinate direction and a Galerkin procedure is applied to the entire problem. In the other, the method of lines is used with DG-SEM in space and the fully implicit Runge–Kutta method Lobatto IIIC in time. The two approac

A Second‑Order Finite Volume Method for Field‑Scale Reservoir Simulation

Subsurface reservoirs are large complex systems. Reservoir flow models are defined on complex grids that follow geology with relatively large block sizes to make consistent simulations feasible. Reservoir engineers rely on established reservoir simulation software to model fluid flow. Nevertheless, fluid front position inaccuracies and front smearing on large grids may cause significant errors and

Climate-change worry among two cohorts of late adolescents : Exploring macro and micro worries, coping, and relations to climate engagement, pessimism, and well-being

Few studies have explored climate change worry in an in-depth manner among adolescents. Through survey studies with two cohorts of adolescents (2010, 2019/2020) we investigated relations between different forms of climate change worry, mental well-being, and pro-environmental behavior and what role coping plays in these relationships. Results show that climate change worry was negatively associate

How people update their beliefs about climate change : An experimental investigation of the optimistic update bias and how to reduce it

People usually update their beliefs selectively in response to good news and disregard bad news. Here, we investigated in two preregistered experiments (N = 278 and N = 306) (1) whether such valence-dependent belief updating also underlies information processing in the context of climate change and (2) whether it can be altered by interventions informing about different aspects of climate change.

“Toxic, but in a good way” : H&M in Russia during the Ukraine war as seen through consumer activism on TikTok

While scholars have explored how business has increasingly been involved in socio-political issues (Scherer et al., 2016; van der Meer & Jonkman, 2021), less attention has been given to the process of how businesses are held accountable for those issues by stakeholders (Reinecke & Ansari, 2016). Current studies show that multinational corporations are sometimes forced to take a stand on di

Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia

Frontotemporal dementia (FTD) is the second most prevalent type of early-onset dementia and up to 40% of cases are familial forms. One of the genes mutated in patients is CHMP2B, which encodes a protein found in a complex important for maturation of late endosomes, an essential process for recycling membrane proteins through the endolysosomal system. Here, we have generated a CHMP2B-mutated human

Transfer patterns in the Swedish football clubs – a gift economy of loyalties and emotions

This article explores how football players and scouts in Sweden narrate their stories of transfers within the Swedish football system. This article presents first-person narrations as male players as well as scouts from elite clubs were interviewed in connection to transfer patters to, from and within Sweden. The aim is to analyse how the transfer system takes shape in stories presented by scouts

Linking soil depth to aridity effects on soil microbial community composition, diversity and resource limitation

With ongoing climate change, aridity is increasing worldwide, affecting biodiversity and ecosystem function in drylands. However, how the depth-profile microbial community structure and metabolic limitations change along aridity gradients are still poorly explored. Here, 16S rRNA and ITS amplicon sequencing and ecoenzymatic stoichiometry analysis were used to investigate both bacterial and fungal

Non-destructive strength testing of microindented float glass by a nonlinear acoustic method

The present paper describes a method for non-destructive testing of the glass strength. Square 10 × 10 cm2 samples of annealed float glass was inflicted with a controlled defect in the centre of the atmospheric side using Vickers microindentation-induced cracking with a force of 2 N, 5 N and 10 N and compared to an un-indented reference. The samples were non-destructively tested using a nonlinear

GIS-based hydrodynamic modeling for urban flood mitigation in fast-growing regions : a case study of Erbil, Kurdistan Region of Iraq

Floods threaten urban infrastructure, especially in residential neighborhoods and fast-growing regions. Flood hydrodynamic modeling helps identify flood-prone locations and improve mitigation plans' resilience. Urban floods pose special issues due to changing land cover and a lack of raw data. Using a GIS-based modeling interface, input files for the hydrodynamic model were developed. The physical