To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 x 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 x 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 x 10(-9)) and 22q13.1 (rs877

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded polyglutamine repeat in the huntingtin protein. Neuropathology in the basal ganglia and in the cerebral cortex has been linked to the motor and cognitive symptoms whereas recent work has suggested that the hypothalamus might be involved in the metabolic dysfunction. Several mouse models of HD that display metabol

Poly(amido amine) (PAMAM) dendrimers have previously been shown, as cationic condensing agents of DNA, to have high potential for nonviral gene delivery. This study addresses two key issues for gene delivery: the interaction of the biomembrane with (i) the condensing agent (the cationic PAMAM dendrimer) and (ii) the corresponding dendrimer/DNA aggregate. Using in situ null ellipsometry and neutron

Two coexisting facets of warm nuclei, quantum chaos and structure of the level density, are considered. A newly developed combinatorial level-density model is presented, and the role of collective enhancements discussed. An example of extreme parity enhancement is shown.

Immune responses against modified self-antigens generated by hypercholesterolemia play an important role in atherosclerosis identifying the immune system as a possible novel target for prevention and treatment of cardiovascular disease. It has recently been shown that these immune responses can be modulated by subcutaneous injection of adjuvant. In the present study we immunized 25-week old ApoBec

Popular Abstract in Swedish Cancer är ett samlingsnamn för flera hundra sjukdomar som har gemensamt att de har fått en okontrollerad celldelning till följd av genetiska förändringar. Celldelning sker ständigt i vår kropp när gamla celler måste bytas ut och nya kopior bildas. Vid dessa processer sker det ofta mutationer i vårt DNA så att informationen förändras, vilket resulterar i att skadan kopieNormal tissue is tightly controlled to keep a balance between reproduction and elimination of cells. In cancer, these regulated processes are disrupted, resulting in uncontrolled cell growth. Regulation of RNA stability and turnover is important to maintain cellular homeostasis and can be controlled by various mechanisms. During stress, the cell can form cytoplasmic complexes of proteins and RNAs,

Grating-based phase-contrast computed tomography (PCCT) is a promising imaging tool on the horizon for pre-clinical and clinical applications. Until now PCCT has been plagued by strong artifacts when dense materials like bones are present. In this paper, we present a new statistical iterative reconstruction algorithm which overcomes this limitation. It makes use of the fact that an X-ray interfero

Since the early 1960s, water chemistry and phytoplankton have been monitored in several lakes in Sweden. However, as early as 1900-1901, the German algologist Lemmermann investigated phytoplankton from lakes in Scania, southern Sweden. Several phytoplankton samples from these investigations were preserved and saved, and are deposited at the Department of Ecology in the University of Lund. These ol

In this note we explain how X. Tolsa's work on analytic capacity and an adaptation of Thomson's coloring scheme can be used to obtain a quantitative version of J. Thomson's theorem on bounded point evaluations for P-t(mu)-spaces.

The consumption of alcoholic beverages has wide effects, for example, causes premature mortality, prevents certain heart diseases, increases crime rates, and affects quality of life. The main problems with alcohol consumption from an economic point of view are lack of information for consumers when making consumption decisions, externalities, and the addictive nature. It is expected that this resu

We review density functional theory studies of various types of reactions performed by the cytochrome P450 family of enzymes. We describe the various reactions on equal footing with an emphasisis on models to predict sites of metabolism for an arbitrary molecule. The activation barriers range between 0 and 109 kJ/mol, depending more on the atoms surrounding the reactive site than on the type of re

When robots are working in dynamic environments, close to humans lacking extensive knowledge of robotics, there is a strong need to simplify the user interaction and make the system execute as autonomously as possible. For industrial robots working side-by-side with humans in manufacturing industry, AI systems are necessary to lower the demand on programming time and expertise. One central conce

Background. In metastatic colorectal cancer, mutation testing for KRAS exon 2 is widely implemented to select patients with wild-type tumors for treatment with the monocloncal anti-EGFR antibodies cetuximab and panitumumab. The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K-AKT-mTOR pathways in colorectal cancer is uncertain, which led us to systematically review the

Geographical accessibility is fundamental when planning rescue services. At present there are several programs for computing the accessibility of stationary rescue units. This study suggests a method for evaluating geographic accessibility in scenarios containing also non-stationary units. The method supports the planning process by matching the risk of an incident occurring with the rescue units’

Objectives To identify effect modification produced by genetic traits found in metabolic enzymes, to investigate how these affect the levels of different biomarkers of sprayed and thermo-degraded polyurethane (PUR) based on 4,4′-diphenylmethane diisocyanate (MDI) and to determine how associated respiratory disorders are affected. Methods Two partly overlapping groups of 141 and 158 factory employe

In this communication, we add another piece of evidence in favor of a parametric split to do with AGR (Holmberg 2010) between Insular (ISc) and Mainland Scandinavian (MSc); the extended possibility of non-subject fronting in embedded clauses, here referred to as Extended verb second (xV2), available in ISc, unavailable in MSc. By adding this phenomenon to the list of AGR-related differences betwee

Previous electrophysiological studies of automatic language processing revealed early (100-200 ms) reflections of access to lexical characteristics of speech signal using the so-called mismatch negativity (MMN), a negative ERP deflection elicited by infrequent irregularities in unattended repetitive auditory stimulation. In those studies, lexical processing of spoken stimuli became manifest as an