Mechanisms of “cocktail effects” in skin sensitization – investigation of (danger) signal integration and the role of autophagy in a dendritic cell model
Exposure to skin sensitizers on a daily basis has been leading to a high prevalence of allergic contact dermatitis (ACD) among the general population. Single substances have been thoroughly studied for their skin sensitizing potential, yet little is known about the cellular mechanisms of so-called “cocktail effects” of mixtures. It has been suggested that induction of oxidative stress, and more re
