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The variable outcome to standard immunochemotherapy for mantle cell lymphoma (MCL) patients is a clinical challenge. Established risk factors, including high MCL international prognostic index (MIPI), high proliferation (Ki-67), non-classic (blastoid/pleomorphic) morphology, and mutated TP53, only partly identify patients in need of alternative treatment. Deepened understanding of biological facto

Dissertation for the degree of a candidate of technical sciences (doctor of philosophy) in specialty 05.03.01 "Processes of mechanical processing, machine tools and tools" –V. Bakul Institute for Superhard Materials NAS of Ukraine, Kyiv, 2019.The actual scientific and technical goal of improving the efficiency of drilling holes in CFRP and GFRP parts has been solved by increasing of tool life thro

BACKGROUND: In experimental animal studies, exposure to general anesthesia in early childhood may results in changes in infant brain morphology and behavior, potentially leading to the development of autistic behaviors in the long-term. However, in clinical studies the role of exposure to general anesthesia in early childhood and the risk of autism is unknown. METHODS: This is a population-based c

The Kelly framework is the natural multi-period extension of the one-period mean-variance model of Markowitz in the sense that the efficient frontier is characterized by trading strategies having maximal instantaneous Sharpe ratio. We show that Kelly traders naturally trade in such a way as to induce an equilibrium for the instantaneous covariance matrix. This equilibrium, arising from trading alo

With the popularization of the concept of the metaverse, non-immersive virtual reality (VR) has become a focus of tourism destination marketing. Drawing upon telepresence theory, this study identifies the antecedents and consequences of telepresence to help interpret tourist behavior in the context of non-immersive VR experience. Results revealed that mental imagery and vividness positively predic

Background: Good care of the dying has been defined as being able to die in the place of your choice, free from pain, cared for with dignity and supported by the best possible care. This definition underpinned the development of the ‘10/40 Model’ of care for the dying, in 2013. The model includes 10 ‘Key Principles’ that underpin 40 ‘Core Outcomes’ of care. It was necessary to update consensus on

Green infrastructure (GI) is increasingly used in policymaking to promote biodiversity and enhance ecosystem services through the protection, creation, restoration and connection of natural and man-made green areas. The EU Commission adopted in 2013, the concept as a strategy. When member states apply the policy, it is translated into specific bureaucratic and political systems, creating different

Background: Sexual dysfunction is common following a cancer diagnosis in young adulthood (18–39 years) and problems related to sex life are ranked among the core concerns in this age group. Yet, few studies have investigated to what extent adults younger than 40, receive information from healthcare providers about the potential impact of cancer and its treatment on their sex life. Methods: A popul

The rapid expansion of industrial agriculture in rural Bogotá has led to a reduction in the diversity of plants cultivated by peasant families. This generates transformations in livelihoods and biocultural relations, affecting local environmental knowledge and practices for the use and management of agrobiodiversity. Although several studies have documented the presence of agrobiodiversity niches,

Objective: To report the risk of venous thromboembolism (VTE) after partial nephrectomy in Denmark. Materials and methods: A nationwide population-based registry was used to conduct a retrospective cohort study. All partial nephrectomies from January 2010 to August 2018 were assessed for postoperative VTE events. Univariable and multivariable analyses were used to evaluate the odds of postoperativ

Biogenic volatile organic compound (BVOC) emissions from trees subjected to biotic stress are higher compared to healthy trees, and they may also have a different compound composition. This in turn affects atmospheric chemistry and can lead to either positive or negative feedback to the climate. Climate change favors the abundance of the European spruce bark beetle (Ips typographus) which attacks

Evaluation is ubiquitous in current (academic) science, to the extent that it is relevant to talk about an evaluation regime. How did it become this way? And what does it mean for scientists, groups, organizations, and fields? Picking up on the inspiring debate in a previous issue of this journal, four articles in this special section go deeper in studying the causes and consequences of the curren

Purpose: We developed a method of standardizing the heart-to-mediastinal ratio in 123I-labeled meta-iodobenzylguanidine (MIBG) images using a conversion coefficient derived from a dedicated phantom. This study aimed to create a machine-learning (ML) model to estimate conversion coefficients without using a phantom. Methods: 210 Monte Carlo (MC) simulations of 123I-MIBG images to obtain conversion

Coastal eutrophication due to excessive anthropogenic nutrient loading is a major threat worldwide, and especially in estuaries and semi-enclosed waterbodies, like the brackish Baltic Sea. In addition, coastal waters may become darker (coastal darkening) due to increased input of colored compounds from terrestrial run-off and sediment resuspension. Still, the effects of darkening on coastal food w

The real Ginzburg–Landau equation arises as a universal amplitude equation for the description of pattern-forming systems exhibiting a Turing bifurcation. It possesses spatially periodic roll solutions which are known to be stable against localized perturbations. It is the purpose of this paper to prove their stability against bounded perturbations, which are not necessarily localized. Since all s

Background: Autoimmune diseases are associated with many cancers but there is a lack of population-based studies with different autoimmune diseases that have a long follow-up. This is also true of hepatobiliary cancers, which include hepatocellular cancer (HCC) and rarer entities of gallbladder cancer (GBC), intra- and extrahepatic cholangiocarcinoma (iCCA and eCCA), and ampullary cancer. Methods: