Background: Total tau (tTau) and phosphorylated 181P tau (pTau) are supportive diagnostic cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease. Manual CSF tau assays are limited by lot-to-lot and between-laboratory variability and long incubation/turnaround times. Elecsys® Total-Tau CSF and Phospho-Tau (181P) CSF immunoassays were developed for fully automated cobas e analyzers, allowing b

Single-chain variable fragments (scFv) are widely used in several fields. However, they can be challenging to purify unless using expensive Protein L-based affinity adsorbents or affinity tags. In this work, a purification process for a scFv using mixed-mode (MM) chromatography was developed by design of experiments (DoE) and proteomics for host cell protein (HCP) quantification. Capture of scFv f

Background: As neurophysiologic tests may not reveal the extent of brachial plexus injury at the early stage, the role of early radiological work-up has become increasingly important. The aim of the study was to evaluate the concordance between the radiological and clinical findings with the intraoperative findings in adult patients with brachial plexus injuries.Methods: Seven consecutive male pat

Introduction: Dupuytren's disease (DD), commonly affecting European men, is generally treated with surgery. Methods: Orthopaedic and plastic surgeons who had been practicing for >3 and

Introduction: Dupuytren's disease (DD) causes progressive digital flexion contracture and is more common in men of European descent. Methods: Orthopaedic and plastic surgeons in 12 European countries (the Czech Republic, Denmark, Finland, France, Germany, Hungary, Italy, The Netherlands, Poland, Spain, Sweden and the UK) with >3 and

Konferensbidrad, 10:e Pedagogiska inspirationskonferensen, December 2018, LTHThe architectural community needs to be better at managing a diversity of experiences, desires and needs associated with architecture. How can students' call for a more problematizing and inclusive education and industry be used as a basis for student and teacher collaboration, as well as an educational platform for raising diversity issues? The Symposium Expanding Architecture - Critical Perspect

Background: The aim was to evaluate what can be learned from rat models when treating patients suffering from a sciatic nerve injury.Methods: Two patients with traumatic sciatic nerve injury are presented with examination of motor and sensory function with a five-year follow-up. Reconstruction of the nerve injury was performed on the second and third day, respectively, after injury using sural ner

The limit of validity of linear fracture mechanics is specified by the minimum allowable crack length through an ASTM convention. Extension into the non-linear region ought to imply an extension towards smaller allowable Cracks. In order to elucidate the question "How short is the smallest crack that fits the methods of fracture mechanics, and how do shorter cracks than that behave?" a pilot inves

In this review we summarize the events known to occur after an injury in the peripheral nervous system. We have focused on the Schwann cells, as they are the most important cells for the repair process and facilitate axonal outgrowth. The environment created by this cell type is essential for the outcome of the repair process. The review starts with a description of the current state of knowledge

A nerve injury has a profound impact on the patient's daily life due to the impaired sensory and motor function, impaired dexterity, sensitivity to cold as well as eventual pain problems. To perform an appropriate treatment of nerve injuries, a correct diagnosis must be made, where the injury is properly classified, leading to an optimal surgical approach and technique, where timing of surgery is

Background: Hand injuries occur at all ages. With an aging population globally an increasing number of hand injuries among the elderly is to be expected. The aim of the present study is to describe the health characteristics and detailed injury patterns for elderly with hand injuries, with incidence, as a background for further studies on the topic. Specific knowledge is currently lacking about ha

Konferensbidrag, PLANNORD 2019: Future challenges for Nordic planning, Augusti 2019, The Norwegian University of Life Sciences (NMBU), Department of Urban and Regional PlanningAbstract to PLANNORD 2019: Future challenges for Nordic planning

Konferensbidrag, Common Ground, IFLA World Congress 2019, September Oslo

Studies of crack behaviour and fracture are generally performed using continuum analysis. Thus, the process region is either not considered at all or assumed to be point-sized. In the latter case it is often ascribed a desired property, usually the ability to consume energy.A major step towards the understanding of the fracture process region the concept of autonomy of the near tip field was intro

Konferensbidrag, Dialogue in Turbulent Times: 6th International Degrowth Conference for Ecological Sustainability and Social Equity, Malmö, Augusti 2018

Konferensbidrag, The Urban Creativity Conference, Pufendorf Institute for Advanced Studies, Maj 2019, Lund University

Report from Solid Mechanics, Lund Institute of Technology, Lund University, Lund Sweden