Estrogens are important regulators of bone mass and their effects are mainly mediated via estrogen receptor(ER)α.CentralERα exertsaninhibitoryroleonbonemass.ERα ishighlyexpressedinthearcuate (ARC) and the ventromedial (VMN) nuclei in the hypothalamus. To test whether ERα in proopiomelanocortin (POMC) neurons, located in ARC, is involved in the regulation of bone mass, we used mice lacking ERα expr

Background: Extracellular vesicles (EV) are nano-sized membranous structures released from most cells. They have the capacity to carry bioactive molecules and gene expression signals between cells, thus mediating intercellular communication. It is believed that EV confer protection after ischemic preconditioning (IPC). We hypothesize that myocardial ischemic preconditioning will lead to rapid alte

The screenplay written by Italian screenwriter and film director Massimo Franciosa in 1995 andfreely based on the short story Checchina’s virtue (1884) by Italian novelist and journalist MatildeSerao (1856-1927) is an example of those submedia ”designed especially to be transmediated”,according to Elleström (2014, 26). The transmediation never occurred however, since the filmnever came into being,

The traditional family unit has historically been considered a fundamental element of Vietnamese society. Despite legislation which has declared the equality of men and women, in reality, household gender roles remain fixed and often unequal, and family members are not expected to deviate from the norm. Men hold the dominant position within the household, and the belief that the husband can legiti

Many experiments have shown that loss of biodiversity reduces the capacity of ecosystems to provide the multiple services on which humans depend. However, experiments necessarily simplify the complexity of natural ecosystems and will normally control for other important drivers of ecosystem functioning, such as the environment or land use. In addition, existing studies typically focus on the diver

Thermosensitive Transient Receptor Potential (TRP) channels are believed to respond to either cold or heat. In the case of TRP subtype A1 (TRPA1), there seems to be a species-dependent divergence in temperature sensation as non-mammalian TRPA1 is heat-sensitive whereas mammalian TRPA1 is sensitive to cold. It has been speculated but never experimentally proven that TRPA1 and other temperature-sens

Aquaporins (AQPs) also referred to as Major intrinsic proteins, regulate permeability of biological membranes for water and other uncharged small polar molecules. Plants encode more AQPs than other organisms and just one of the four AQP subfamilies in Arabidopsis thaliana, the water specific plasma membrane intrinsic proteins (PIPs), has 13 isoforms, the same number as the total AQPs encoded by th

The traditional pre-post treatment difference reflects an incremental notion of change, where a quantity of some psychological function is added to (or subtracted from) a pretreatment quantity. This study presents a complementary, experiential notion of change. Rather than a difference, change is a feeling or experience of having changed, a feeling that one is different than before. Based on a pos

In this study, a label-free, selective and sensitive microcontact imprinted capacitive biosensor was developed for the detection of Escherichia coli. The recognition of E. coli was successfully performed by this sensor prepared with the combination of microcontact imprinting method and capacitive biosensor technology. After preparation of bacterial stamps, microcontact-E. coli imprinted gold elect

The aim of this study was to investigate whether various dimensions of student–teacher relationships were associated with different types of motivation to defend victims in bullying and to determine the association between these types of motivations and various bystander behaviors in bullying situations among early adolescents in Italy. Data were collected from 405 Italian adolescents who complete

Elektroaktiva polymerers (EAPs) främsta egenskap är deras förmåga att kunna omvandla elektrisk energi till mekanisk energi (och vice versa). Den typ av EAPs som behandlas inom ramen för detta arbete kallas för dielektriska elastomerer och är en undergrupp av elektroniska elektroaktiva polymerer. De karakteriseras av en väldigt låg elastisk styvhet, kapabel till stora elastiska deformationer, och a

The cadastre of King Valdemar is one of the most investigated and debated written sources that survive from early medieval Denmark. In particular, the detailed list of revenue from Halland has attracted a lot of attention. Despite this, many unanswered questions still remain. This article attempts to address some of these queries.

Ultrafiltration and nanofiltration have become common methods to treat surface water for drinking water purposes. Common aims of a membrane step are removal of natural organic matter (NOM), softening or adding an extra microbiological or chemical barrier. In most cases, the membrane is considered a good disinfection step; commonly the viral removal is at least 4–log. To ensure a working disinfecti

The molecular details and impact of oligosaccharide uptake by distinct human gut microbiota (HGM) are currently not well understood. Non-digestible dietary galacto- and gluco-α-(1,6)-oligosaccharides from legumes and starch, respectively, are preferentially fermented by mainly bifidobacteria and lactobacilli in the human gut. Here we show that the solute binding protein (BlG16BP) associated with a

Screening studies of a population in primary health care are sparsely reported. The aim was to describe observed atypical behaviours that may be associated with autism spectrum conditions, in a population (n = 4329) of infants at eight months. Observations were performed by paediatric nurses. An observational instrument, named SEEK developed for child health care, was used focusing on social inter

Kalamang is Papuan language spoken by 150 people in the east of Indonesia. The language is threatened with extinction. This thesis treats mainly phonetics and phonology, but also gives an overview over parts of Kalamang grammar. Pronouns, demonstratives, nominal morphology and some basic syntax are discussed, among other things. The thesis also includes a word list with 700 Kalamang lexemes, and a

Moderniserad (dvs. inte textkritisk) utgåva av Johan Gabriel Oxenstiernas främsta dikter. Utförliga noter som förklarar språkliga ting såväl som referenser till kontexten, anspelningar på äldre litteratur och liknande. Utgiven i Svenska akademiens klassikerserie. Med förord av Horace Engdahl.Modernized (i.e. NOT critical) edition of the major poems of Johan Gabriel Oxenstierna. Extensive notes explaining linguistic difficulties in the text as well as information on context, literary allusions etc. In the Swedish Academy's book series Swedish Classics, with a preface by academy member Horace Engdahl.