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Genomic Profiles of Neuroblastoma Associated With Opsoclonus Myoclonus Syndrome

Opsoclonus myoclonus syndrome (OMS), often called "dancing eyed syndrome," is a rare neurological condition associated with neuroblastoma in the majority of all childhood cases. Genomic copy number profiles have shown to be of prognostic significance for neuroblastoma patients. The aim of this retrospective multicenter study was to analyze the genomic copy number profiles of tumors from children w

LSC - 2017 - Hippo-YAP/TAZ signaling is deranged in IPF

Objective: Idiopathic pulmonary fibrosis (IPF) is a devastating disease with no cure and is characterized by deranged epithelial repair, myofibroblast activation, and excess deposition of extracellular matrix. Yes associated protein (YAP) and transcriptional co-regulator with PDZ-binding domain(TAZ), co-transcriptional activators of the Hippo pathway and proto-oncogenes, were recently found to be

Rescue Effect Inherited in Colony Formation Assays Affects Radiation Response

It is well known that nonirradiated cells can exhibit radiation damage (bystander effect), and recent findings have shown that nonirradiated cells may help protect irradiated cells (rescue effect). These findings call into question the traditional view of radiation response: cells cannot be envisioned as isolated units. Here, we investigated traditional colony formation assays to determine if they

Characteristics of BVOC emissions from a Swedish boreal forest : Using chambers to capture biogenic volatile organic compounds (BVOCs) from trees and forest floor

Plant-emitted biogenic volatile organic compounds (BVOCs) are a large group of hydrocarbons released by plant leaves, bark, flowers and fruits into the atmosphere and from plant roots into the soil. BVOCs have important physiological and ecological functions, such as mediating within-plant and plant-plant communication, defense against herbivores attack, protection against heat or other oxidative

Physical neglect during childhood alters white matter connectivity in healthy young males

Background: Childhood adversity (CA) leads to greater vulnerability for psychopathology by causing structural as well as functional brain abnormalities. Recent findings on gray matter effects point towards the importance of identifying CA outcome as a function of different CA types, varying in the dimensions of threat and deprivation. Using diffusion tensor imaging, we investigate whether differen

From Conflict to Compromise : The importance of mediation in Swedish work stoppages 1907-1927

Institutions for prevention and resolution of labor market conflicts were introduced all over the world in the early twentieth century. In this paper we analyze the impact of mediation on compromise outcomes in Swedish labor market conflicts, using a dataset of geo-coded strikes and lockouts from 1907 to 1927. Causality is identified by using the distance from the mediator's residence to the confl

In search of features that constitute an "enriched environment" in humans : Associations between geographical properties and brain structure

Enriched environments elicit brain plasticity in animals. In humans it is unclear which environment is enriching. Living in a city has been associated with increased amygdala activity in a stress paradigm, and being brought up in a city with increased pregenual anterior cingulate cortex (pACC) activity. We set out to identify geographical characteristics that constitute an enriched environment aff

Day2day : Investigating daily variability of magnetic resonance imaging measures over half a year

Background: Most studies of brain structure and function, and their relationships to cognitive ability, have relied on inter-individual variability in magnetic resonance (MR) images. Intra-individual variability is often ignored or implicitly assumed to be equivalent to the former. Testing this assumption empirically by collecting enough data on single individuals is cumbersome and costly. We coll