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Recent advances have extended the scope of Bayesian optimization (BO) to expensive-to-evaluate black-box functions with dozens of dimensions, aspiring to unlock impactful applications, for example, in the life sciences, neural architecture search, and robotics. However, a closer examination reveals that the state-of-the-art methods for high-dimensional Bayesian optimization (HDBO) suffer from degr
Objective: To develop a method for detection of bradycardia and ventricular tachycardia using the photoplethysmogram (PPG). Approach: The detector is based on a dual-branch convolutional neural network (CNN), whose input is the scalograms of the continuous wavelet transform computed in 5-s segments. Training and validation of the CNN is accomplished using simulated PPG signals generated from RR in
Solid-state properties of dried protein formulations are important for stability and functionality of the product. This study investigates how different drying technologies (freeze-drying with and without annealing, spray drying and spray-freeze drying) affect the structure and solid-state properties of a set of matrix formulations composed of trehalose (glass former) and mannitol (scaffolding age
Reconstruction of movement control properties of the brain could result in many potential advantages for application in robotics. However, a hampering factor so far has been the lack of knowledge of the structure and function of brain circuitry in vivo during movement control. Much more detailed information has recently become available for the area of the cerebellum that controls arm-hand movemen
Plant development is regulated by transcription factors that often act in more than one process and stage of development. Yet the molecular mechanisms that govern the functional diversity and specificity of these proteins remains far from understood. Flower development provides an ideal context to study these mechanisms since the development of distinct floral organs depends on similar but distinc
Background: Around 70% of all ICU patients are treated with antibiotics whereas up to 30% are suggested as unnecessary. Measuring antibiotic consumption is a prerequisite to improving its use and the purpose of the present investigation was to explore the use of antibiotics in Swedish ICUs. Material and methods: Daily Defined Doses (DDDs) of antimicrobials delivered to Swedish ICUs, 2016–2018, wer
Jet impingement cooling was investigated on a flat heating surface placed in a flow channel, including single jet cooling, in-line double jet cooling, and combined crossflow and jet cooling; cross-flow cooling was a baseline for comparison. In addition, the in-line double jet cooling was explored with various jet distances. Local Nusselt number distribution was experimentally achieved by the liqui
This paper highlights changes in perceived room for agency and local institutions (formal and informal) in old Swedish mill regions. The paper draws on recent literature on change agency (Grillitsch & Sotarauta, 2020) and reproductive agency (Bækkelund, 2021; Jolly et al., 2020) as well as the role of institutions in local communities (Bole, 2021; Rodríguez-Pose, 2013) and builds on material f
Aim: To investigate school nurses’ experiences of health-promoting work to prevent stress in Swedish adolescents. Materials and methods: Swedish school nurses (n = 225) responded to a web survey with open-ended questions. The results were subjected to a qualitative content analysis. Results: Six categories were identified from the analysis: (1) Knowledge of body and soul, (2) Identifying stress an
Objective: To estimate the genetic contribution to doctor-diagnosed hand osteoarthritis (OA). Methods: Using data from the Swedish Twin Registry and National Patient Register, we conducted a 20-year population-based longitudinal cohort study including 59,970 twins aged 35 years or older. We studied inpatient and outpatient doctor-diagnosed hand OA using ICD-10 codes from 1997 until 2016, including
The extraction of the W-boson mass, a fundamental parameter of the Standard Model, from hadron-hadron collision requires precise theory predictions. In this regard, angular coefficients are crucial to model the dynamics of W-boson production. In this work, we provide, for the first time, angular coefficients at NNLO QCD + NLO EW accuracy for finite transverse momentum W-boson at the LHC. The corre
We use principal component analysis to study the hydrodynamic attractor in Yang-Mills kinetic theory undergoing the Bjorken expansion with color glass condensate initial conditions. The late-time hydrodynamic attractor is characterized by a single principal component determining the overall energy scale. How it is reached is governed by the disappearance of single subleading principal component ch
Background: We aimed to describe baseline characteristics of patients with oral anticoagulant-related intracerebral hemorrhage (OAC-ICH) in Sweden and to identify predictive variables associated with receiving hemostatic treatment in the event of OAC-ICH. Methods: We performed an observational study based on data from Riksstroke and the Swedish Causes of Death Register to define baseline character
The ordinary Black diagram of bitumen has only two dimensions. Thus, it does not differentiate the complex shear modulus and phase angle measured under different temperature and frequency conditions. This study proposes to extend the Black diagram to three dimensions by adding a temperature axis. It leads to the combination of multiple necessary ordinary plots in the same three-dimensional (3D) sp
Multiple sclerosis (MS) is a chronic neurological disease believed to be caused by autoimmune pathogenesis. The aetiology is likely explained by a complex interplay between inherited and environmental factors. Genetic investigations into MS have been conducted for over 50 years, yielding >100 associations to date. Globally, the strongest linkage is with the human leukocyte antigen (HLA) HLA-DRB5*0
Introduction: In Sweden, partner's presence during childbirth is generally recommended. However, cultural values and norms in some immigrant societies can be an obstacle to this. Objective: To examine the experiences of Cameroonian fathers during their women's labour and childbirth in Sweden. Design: An exploratory qualitative study with semi-structured interviews were used for data collection and
To improve the power handling capability at ground stations of a 5.8-GHz solar space power satellite using microwave power transmission, a power charge-pump meta-semiconductor field-effect transistor (MESFET)-based rectifier is presented in this article. Unlike conventional microwave Schottky diodes, diode-connected MESFETs, whose nonlinear characteristics help them to have a unique current&#x
