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Background: Lung injury in COVID-19 is characterized by neutrophil invasion and the release of neutrophil extracellular traps (NETs). An aberrant NET formation may induce local inflammation and increase sputum viscosity. Inhalation of DNase I (dornase alfa) is a treatment option that degrades NETs in the airways. Previous case series have indicated positive clinical effects of inhaled dornase alfa

We compare measurements of star formation efficiency to cloud-scale gas properties across the PHANGS- ALMA sample. Dividing 67 galaxies into 1.5 kpc scale regions, we calculate the molecular gas depletion time τ dep mol = Σ mol / Σ SFR and the star formation efficiency per freefall time ϵ ff mol = τ ff / τ dep mol for each region. Then we test how τ dep mol and ϵ ff mol vary as functions of the re

On March 30, 2022, Inno4Vac, a public-private partnership funded by the IMI2/EU/EFPIA Joint Undertaking (IMI2 JU), organised a hybrid workshop, titled “Regulatory Dialogue for Road Maps of Implementation of New Tools in Chemistry, Manufacturing, and Controls Dossiers.” This event brought together modellers, regulatory experts, and academic and industry professionals specialising in vaccine process

The main information in DNA is its four-letter sequence that builds up the genetic information and that is traditionally read using sequencing methodologies. DNA can, however, also carry other important information, such as epigenetic marks and DNA damage. This information has recently been visualized along single DNA molecules using fluorescent labels. Quantifying fluorescent labels along DNA is

As the field of metal halide perovskites matures, a range of compositionally different perovskite films has found a place in efficient optoelectronic devices. These films feature variable local structural stability, carrier diffusion, and recombination, while there is still a lack of easy-to-implement generic protocols for high-throughput characterization of these variable properties. Correlation

Background. Inherited kidney diseases (IKDs) and congenital anomalies of the kidney and urinary tract (CAKUT) are causes of kidney failure requiring kidney replacement therapy (KRT) that major renal registries usually amalgamate into the primary renal disease(PRD) category ‘miscellaneous’ or in the glomerulonephritis or pyelonephritis categories. This makes IKDs invisible (except for polycystic ki

Recent years have seen major advances in tau-associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The Tau2024 Global Conference, hosted by the Alzheimer's Association, CurePSP, and Rainwater Charitable Foundation, showcased these efforts by bringing together researchers and experts worldwide to discuss

Intrapersonal diversity has emerged as an important trait among top managers, significantly improving firm and team performance. However, existing research treats this diversity as static orexogenously given, overlooking its developmental origins. Drawing on imprinting theory, we explore how early-childhood parental diversity and later-life crisis events shape a manager’s decision to acquire this

District heating and cooling is a simple but powerful technology that could contribute to decarbonising Europe's heating and cooling supply. However, its current overall penetration is minor. Furthermore, future systems could adopt different configurations with various settings of temperature levels or production location. This thesis has aimed to improve existing tools to evaluate district heatin

BACKGROUND: Despite the high level of economic development in the Group of Seven (G7) countries, injury deaths remain a public health concern in these countries. This paper examines the contribution of injury deaths to changes in life expectancy (LE) and life disparity (LD) in the G7 countries.METHODS: We used annual data from the WHO mortality database to compute LE and LD during 2001-03 and 2017

This paper presents a snapshot of a neolithic maritime exchange network centred on the Pitted Ware Culture (PWC) site of Tråsättra (circa 2630 to 2470 BCE), located northeast of modern-day Stockholm, Sweden. We used a combination of Inductively Coupled Plasma Mass Atomic Emission Spectrometry (ICP-MA/ES) and thin section analysis to study and source the clays used to produce 19 potsherds and 39 ce

UNLABELLED: Children with congenital and acquired heart disease have an increased risk of thromboembolic events. There is a paucity of evidence on the optimal approach to thromboprophylaxis for this population, and the introduction of direct oral anticoagulants in recent years has led to significant variation in clinical practice. The aim of the study was to describe current practice in thrombopro

Patents are among the most common proxies for innovation, and a long-standing discussion is therefore to what extent patents can be used to monitor trends in innovation activity. This study proposes a new straightforward approach to measure the amount and quality of information content of a data source, where information is approached as a transmission from a source to a receiver through a noisy c

Unraveling the mechanisms underlying the maintenance of species diversity is a central pursuit in ecology. It has been hypothesized that ectomycorrhizal (EcM) in contrast to arbuscular mycorrhizal fungi can reduce tree species diversity in local communities, which remains to be tested at the global scale. To address this gap, we analyzed global forest inventory data and revealed that the relations