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BACKGROUND: A randomized controlled trial of the SMART4MD tablet application was conducted for persons with mild cognitive impairment (PwMCI) and their informal caregivers to improve or maintain quality of life.OBJECTIVE: The objective was to conduct economic evaluation of SMART4MD compared to standard care in Sweden from a healthcare provider perspective based on a 6-month follow-up period.METHOD

En byggnads och stilanalys visar koret sannolikt varit ett solitärt kapell byggt på 1000-talet. Genom dendrokronologiska dateringar har en sannolik datering till omkring 1120 också för det romanska måleriet framkommit. Två valvbärande kolonner visar sig vara av lokal Önnestadsyenit vilka har hämtats i blockterräng vid Djurröd och sannolikt polerats i Vä. Det sannolika polerverkat undersöktes på 19

Den första bransch som kände industrialiseringens verkningar var lantbruket. I Kävlinge trakten förändrades lantbruket på många sätt genom industrialiseringens innovationer, långt innan järnvägen kom och industrierna etablerades.

OBJECTIVE: To combine prospective cohort studies, by including HLA harmonization, and estimate risk of islet autoimmunity and progression to clinical diabetes.RESEARCH DESIGN AND METHODS: For prospective cohorts in Finland, Germany, Sweden, and the U.S., 24,662 children at increased genetic risk for development of islet autoantibodies and type 1 diabetes have been followed. Following harmonization

Tourism enterprises play a vital role in tourism development. This has inspired scholarly and policy interest in the workings of tourism enterprises, particularly the small enterprises that account for the majority. The heterogeneity of small enterprises presents challenging terrain for scholars and policymakers concerned to understand and manage enterprise development and tourism development. Sch

The interaction between DNA methylation of tripartite motif containing 27 (cg05293407TRIM27) and smoking has previously been identified to reveal histologically heterogeneous effects of TRIM27 DNA methylation on early-stage non-small-cell lung cancer (NSCLC) survival. However, to understand the complex mechanisms underlying NSCLC progression, we searched three-way interactions. A two-phase study w

Objectives: To evaluate the feasibility of a population-based screening trial using prostate-specific antigen (PSA), a kallikrein panel and multiparametric magnetic resonance imaging (MRI) aimed at minimizing overdiagnosis, while retaining mortality benefit. Patients and Methods: Feasibility of the screening algorithm was evaluated in terms of participation, screening test results and cancer detec

The Fukushima nuclear disaster posed food safety risks on an unprecedented scale in Japan. In its immediate aftermath, information on the scale and the extent of the contamination of the food chain was scarce. Facing an anxious public, the government was tasked with defining and ensuring food safety amidst uncertainty. Via three case studies spanning from 2011 to 2020, this article draws on risk c

Parkinson’s disease (PD) and Alzheimer’s disease (AD) are characterized by pathological accumulation and aggregation of different amyloidogenic proteins, α-synuclein (aSyn) in PD, and amyloid-β (Aβ) and Tau in AD. Strikingly, few PD and AD patients’ brains exhibit pure pathology with most cases presenting mixed types of protein deposits in the brain. Bimolecular fluorescence complementation (BiFC)

BACKGROUND: The presence of an apolipoprotein E4 (ApoE4) genotype is the major genetic risk factor for Alzheimer's disease (AD). Astrocytes are the main source of ApoE in the brain, however ApoE can also be produced by neurons and microglia. ApoE plays a role in many cell types and processes related to AD, however, it remains unclear which mechanism(s) and cellular source of ApoE are most critical