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Background and ObjectivesIntestinal levodopa/carbidopa gel infusion (LCIG) is superior to oral treatment in advanced Parkinson disease. The primary objective of this trial was to investigate whether continuous subcutaneous or intravenous infusion with a continuously buffered acidic levodopa/carbidopa solution yields steady-state plasma concentrations of levodopa that are equivalent in magnitude, a

Background and ObjectivesIdentifying a clinically meaningful change in cognitive test score is essential when using cognition as an outcome in clinical trials. This is especially relevant because clinical trials increasingly feature novel composites of cognitive tests. Our primary objective was to establish minimal clinically important differences (MCIDs) for commonly used cognitive tests, using a

Climate change and increasing air temperature may alter environmental conditions for developing birds, with a range of phenotypic consequences for offspring. The thermal environment during incubation may affect the trade-off between growth and thermoregulation, but the effects of temperature on the ontogeny of endothermy are not fully understood. Therefore, we experimentally tested whether heating

There exist several datasets for developing self-driving car methodologies. Manually collected datasets impose inherent limitations on the variability of test cases and it is particularly difficult to acquire challenging scenarios, e.g. ones involving collisions with pedestrians. A way to alleviate this is to consider automatic generation of safety-critical scenarios for autonomous vehicle (AV) te

Increasing awareness of the extent of preventable harm from healthcare has led to efforts to improve patient safety through a variety of efforts, including legislation. Extending legal privilege to quality and safety reviews leads to further harm for many patients, families and healthcare providers. The intentional isolation, silencing and exclusion after the incident undermines trust, prevents le

It is well known in economics, law, and sociology that reputation costs in a closed network give insiders a feeling of being protected from bad behavior in their relations with one another. A person accustomed to doing business within a closed network is, therefore, likely to feel at unusual risk when asked to cooperate beyond the network because of absent reputation-cost security. It follows that

Ultrafast lasers reaching extremely high powers within short fractions of time enable a plethora of applications. They grant advanced material processing capabilities, are effective drivers for secondary photon and particle sources, and reveal extreme light-matter interactions. They also supply platforms for compact accelerator technologies, with great application prospects for tumor therapy or me

The sun is the most prominent source of directional information in the heading direction network of the diurnal, ball-rolling dung beetle Kheper lamarcki. If this celestial body is occluded from the beetle's field of view, the distribution of the relative weight between the directional cues that remain shifts in favour of the celestial pattern of polarised light. In this study, we continue to expl

Negation is frequently used in natural language, yet relatively little is known about its processing. More importantly, what is known regarding the neurophysiological processing of negation is mostly based on results of studies using written stimuli (the word-by-word paradigm). While the results of these studies have suggested processing costs in connection to negation (increased negativities in b

The potential of geothermal energy for energy transition is increasingly recognized by governments around the world. Whether geothermal energy is a sustainable source of heat and/or electricity depends on how it is deployed in specific contexts. Therefore, it is striking that there is only limited attention to geothermal energy from a social science and humanities (SSH) perspective. Geothermal ene

Building on insights from ecological economics and philosophy of technology, this book offers a novel, interdisciplinary approach to understand the contradictory nature of Solar photovoltaic (PV) technology.Solar photovoltaic (PV) technology is rapidly emerging as a cost-effective option in the world economy. However, reports about miserable working conditions, environmentally deleterious mineral

This conclusion combines insights from the analysed of urban conflicts over peace(s) to answer the principal research question. The subsequent argument is that the postwar city reinforces rather than transcends its continuities of war into peace because urban conflicts over peace(s) attack its transcending potential and enhance its destructive potential while the city itself—untouched by postwar c

This chapter employs relational space on postwar Belfast (Northern Ireland) to understand the role of space in its urban conflicts over peace(s). The focus is both on how society produces and how it is produced by space in its material, perceived, and lived dimensions. The first line of analysis explores how Belfast’s seemingly given ethnonational geography is not “just there”, but—in contrast—is

Alzheimers och Parkinsons sjukdom är de vanligaste och näst vanligaste neurodegenerativa sjukdomarna som globalt drabbar ca 30 respektive 6 miljoner människor. I och med vår åldrande befolkning kommer det antalet bara att öka. Alzheimers är en demenssjukdom som börjar med minnessvårigheter och slutar med en svårt dement patient där även grundläggande språk och motoriska funktioner är påverkade vil

Background Previous research has associated repeated transurethral procedures after a diagnosis of non-muscle invasive bladder cancer (NMIBC) with increased risk of death of causes other than bladder cancer. Aim We investigated the overall and disease-specific risk of death in patients with NMIBC compared to a background population sample. Methods We utilized the database BladderBaSe 2.0 containin

Background In 2019, Zambia introduced the national health insurance (NHI) as a healthcare financing strategy to increase universal access to health care services. The private health sector can complement public sector providers as service providers under the NHI. As such, the NHI Management Authority seeks to accredit for-profit private healthcare facilities in the NHI. Ascertaining factors that i

Background and purpose National guidelines for treatment of distal radius fractures (DRFs) were presented in Sweden in 2021. In the guidelines, a fast-track is recommended for 4 subgroups of highly unstable DRFs. Regardless of the results of the closed reduction these are recommended for surgery within 1 week of injury. This study aims to evaluate the potential consequences of the newly presented

Background Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable. Aims To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients. Methods Multicentre retrospective cohort study. Caudal sections of the thorax derived from abdominal contrast enhance

Tiden är knapp att nå uppsatta klimatmål. För att nå dit krävs kraftfulla åtgärder och styrning. Det står även klart att vi inte når ett hållbart transportsystem med bara någrafå åtgärder – det krävs att en mängd olika åtgärder och styrmedel kombineras och införs. Utöver ökad energieffektivisering, byte av drivmedel och ökade transportkostnader krävs även åtgärder och styrmedel för ett mer transpo