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Background: Adjuvant endocrine treatment improves survival after estrogen receptor (ER) positive breast cancer. Recurrences occur, and most patients with metastatic breast cancer develop treatment resistance and incurable disease. An influential factor in relation to endocrine treatment resistance is tumor hypoxia and the hypoxia inducible transcription factors (HIFs). Poor perfusion makes tumors

Urgent structural change is required in higher education, to allow collaboration both within and across universities, so that achieving rapid sustainability transition can become not only the overarching but the main purpose of education, research and work in society. A review of the literature reveals that fragmentation caused by traditional hierarchical faculty and disciplinary organisation is a

The Kurdish economy is today heavily dependent on hydrocarbons exports. Current trends are that hydrocarbons exporting and processing countries, as well as interest groups within these countries, are pushing to expand production and maximise profits while this is still possible. The magnitude and observed acceleration of the present climate emergency - with major impacts both in terms of loss of c

Since roughly the turn of the millennium, there has been a growing literature discussing the potential characteristics of African Developmental States—if they exists and in that case how they should be defined and exemplified. The basis for this literature has been the experience of the trajectory for sustained economic growth in Pacific Asia. But it has expanded into a broader discussion about th

AIMS: Although the epidemiological association between Type 2 diabetes and congestive heart failure (CHF) as well as cardiovascular disease (CVD) is well established, associations between diabetes-related single-nucleotide polymorphisms (SNPs), CHF, and CVD have been surprisingly inconclusive. Our aim is to examine if 43 diabetes-related SNPs were associated with prevalent diastolic dysfunction as

Variation of the blood content of the pulmonary vascular bed during a heartbeat can be quantified by pulmonary blood volume variation (PBVV) using magnetic resonance imaging (MRI). The aim was to evaluate if PBVV differs in patients with heart failure compared to healthy controls and investigate the mechanisms behind the PBVV. Forty-six patients and 10 controls underwent MRI. PBVV was calculated f

För hundra år sedan började den katolska tidskriften Credo, föregångaren till dagens Signum, utkomma. Den var på många sätt typisk för sin tid och för de strömningar som då gjorde sig gällande i den katolska världen. I denna artikel analyseras Credo under pionjärtiden de första tolv åren och sätts in i sitt samtida katolska sammanhang.