Filtyp
Dupuytren's disease is a hereditary fibroproliferative disease commonly affecting the palmar fascia of the hand, which results in progressive and irreversibly fixed flexion contractures of the hand. It may occur in the sole of the foot or in the penis. Generally, treatment has been up against a high frequency of complications and recurrence, but promising results are reported from less invasive tr
PurposeThe purpose of this study is to understand current trends and challenges in omnichannel logistics.Based on the study findings, a number of propositions are formulated.Design/methodology/approachAn exploratorysurvey study is conducted with 28Swedish retail companies that are involved with or plan to engage in omnichannel logistics. The study investigates the retailers’ previous
Retail companies increasingly shift to an omni-channelstrategy, allowingconsumers tointeract through a single seamless interface of integrated channels. Thisomni-channeltrend put pressure onlogistics and,particularly, warehousing activities, which need tocombinefulfilment ofretail store-replenishment and web-based consumer orders in an effective and efficient way. This expl
BACKGROUND: Multiparametric magnetic resonance imaging (MRI), with or without targeted biopsy, is an alternative to standard transrectal ultrasonography-guided biopsy for prostate-cancer detection in men with a raised prostate-specific antigen level who have not undergone biopsy. However, comparative evidence is limited. METHODS: In a multicenter, randomized, noninferiority trial, we assigned men
Maf transcription factors are critical regulators of beta-cell function. We have previously shown that reduced MafA expression in human and mouse islets is associated with a pro-inflammatory gene signature. Here, we investigate if the loss of Maf transcription factors induced autoimmune processes in the pancreas. Transcriptomics analysis showed expression of pro-inflammatory as well as immune cell
The author has as a practitioner in industry for 25 years seen a shift in the attitude to corporateresearch. Previously, most established technology firms had substantial departments doing research.Over the years this has changed, and corporate research not seen as short term profitable hasdecreased.A number of papers indicate that the amount of in-house science in technology corporations isindeed
Alliances are volatile key components of many corporations' competitive strategies. They offer fast and flexible means of achieving market access, scale economies, and competence development. However, strategic alliances can encounter difficulties that often lead to disappointing performance. The authors suggest that the way partners manage the collective learning process plays a central role in t
This study has investigated the changes in corporate strategy and performance in 20 large Swedish MNC's between 1985, 1994 and 1998. It has found a strong pattern of product focusing, increased internationalisation, and a strong increase in accounting-based performance. This development seems to be contrary to former empirical evidence, that international diversification pays off better for more p
This article uses case studies to address the sources of social innovation, a major contributor to economic growth and welfare services. Following the findings of user-innovation research in the commercial sector, the authors found that social-problem users innovate new social services for solving specific social problems. They also found that superior problem and solution knowledge is one reason
Surface heparinization of central venous catheters has earlier been shown to reduce the frequency of bacterial colonization and septicaemia. The present study was undertaken to investigate the benefit of surface heparinization of external ventricular drainage (EVD) catheters in relation to bacterial colonization, as measured by bacterial growth and examination by a 16S-rRNA PCR assay, of catheters
The serine-threonine kinase Akt1 promotes cell survival through inhibition of apoptosis. One of the potential downstream targets of Akt1 is p70 S6 kinase, p70(S6K), an enzyme implicated in the regulation of protein synthesis. In this study, we investigated the changes in total and phosphorylated levels of Akt1 and p70(S6K) during transient focal ischemia. Male Wistar rats were subjected to 2 h of
Progress in the definition of the roles of various costimulators and cytokines in determining the type and height of immune responses has made it important to explore genetically altered tumor cells expressing such molecules for therapeutic immunizations. We have studied the effect of therapeutic subcutaneous (s.c.) immunizations on the growth of preexisting intracerebral brain tumor isografts in
