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Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has been shown to be present at synapses and to induce hyperexcitability in mouse knock-in brain regions vulnerable to AD. ApoE in the brain is mainly generated by astrocytes, however, neurons can also produce ApoE under stres
nterspecific hybridization had been long recognized as a widespread evolutionary process in vascular plants. In the present review, we summarize knowledge concerning studies of interspecific hybridization in bryophytes before and after the advent of molecular methods. The available data indicate that hybridization is an important evolutionary phenomenon among bryophytes. evidence for hybridization
Hedley Bull’s searing 1982 critique of the European Community’s ‘civilian power’ in international affairs serves as the point of departure for my discussion of the European Union’s ‘normative power’ in contemporary international society. The idea of using Bull’s examination of civilian power Europe as an entry point to a discussion on the value of using English School terms to study the EU may str
The purpose of this paper is to more fully develop the notion of the international identity of the EU previously suggested by Richard Whitman and myself. I will attempt to balance our previous focus on the ‘active dimension’ of the EU’s attempts to ‘assert its identity on the international scene’ by looking at the ‘reflexive dimension’ of the EU’s international identity from a more sociological pe
The past ten years have seen the steady escalation of attempts tosecuritise the EU which, for good or for bad, are now beginning tosucceed. Across Europe the EU is fast becoming a convincing reason forgroups to mobilise in protest and action - from Copenhagen to Nice toGothenburg the EU has become a synonym for ‘threat’. As this paper willexplore, the securitisation of the EU is occurring as it be
The article uses political psychology to understand how emotions such as fear, anger, hate and passion fuel the construction of emotional norms in foreign policy, and why this is important to the contributing articles to this Global Affairs special issue (SI) on emotion(al) norms in EUropean foreign policy. It argues that the SI sets out a significant stage in the political psychology of emotions
An electronic device requires valid control keys to change any usage restriction setting. The device is provided control keys, a secret key, and a signed software object including a batch ID and a hash of the secret key. For each control key, the device generates a cryptographic footprint bound to the device and the secret key. A message authentication code (MAC) of each usage restriction setting
A message authentication code, MAC, is generated in an electronic circuit, wherein the MAC integrity protects a data value, PD. A random challenge word, RND, is received from a source that is external to the electronic circuit. A first function G(RND,K) is evaluated that generates a first encrypted value, K?, from RND and K, wherein K is a secret key value that is stored on the electronic circuit.
A tamper-resistant electronic circuit is configured for implementation in a device. The electronic circuit securely implements and utilizes device-specific security data during operation in the device, and is basically provided with a tamper-resistantly stored secret not accessible over an external circuit interface. The electronic circuit is also provided with functionality for performing cryptog
A method of protecting an electronic device from unauthorized reprogramming, the electronic device comprising a data memory and a key memory, the method comprising loading into the key memory a predetermined public key of a cryptographic public key mechanism for verifying subsequent data items to be loaded into the data memory, the subsequent data items being signed with a corresponding private ke
Disclosed is a method of loading data, such as software, into a mobile terminal, where the data is loaded from a loading station, and the data comprises payload data and header data. The mobile terminal accepts the data conditioned on a verification process based on the header data. The step of receiving the data further comprises the steps of receiving a header message including the header data f
Since the emergence of SARS-CoV-2 in 2019, Covid-19 has developed into a serious threat to our health, social and economic systems. Although vaccines have been developed in a tour-de-force and are now increasingly available, repurposing of existing drugs has been less successful. There is a clear need to develop new drugs against SARS-CoV-2 that can also be used against future coronavirus infectio
Dwarf birch (Betula nana L.), a dominant deciduous dwarf shrub in many tundra ecosystems, is predicted to increase substantially in abundance due to climate warming. Potential warming-induced changes in the concentrations of phenolic compounds in B. nana leaves could influence the susceptibility of B. nana to environmental stresses; however, only a few studies have investigated the effects of clim
Selective herbivory of palatable plant species provides a competitive advantage for unpalatable plant species, which often have slow growth rates and produce slowly decomposable litter. We hypothesized that through a shift in the vegetation community from palatable, deciduous dwarf shrubs to unpalatable, evergreen dwarf shrubs, selective herbivory may counteract the increased shrub abundance that
Previous studies have offered strong evidence that grazers alter the vegetation composition and ecosystem carbon (C) balance in ecosystems. In Arctic peatlands, however, the role of grazing has remained largely uninvestigated. Falk et al (2015 Environ. Res. Lett. 10 045001) showed that grazing by muskoxen in a high Arctic mire significantly affected both the vegetation and release of greenhouse ga
Arctic tundra currently stores half of the global soil carbon (C) stock. Climate warming in the Arctic may lead to accelerated CO 2 release through enhanced decomposition and turn Arctic ecosystems from a net C sink into a net C source, if warming enhances decomposition more than plant photosynthesis. A large portion of the circumpolar Arctic is grazed by reindeer/caribou, and grazing causes impor
Archaeological 3D GIS provides archaeologists with a guide to explore and understand the unprecedented opportunities for collecting, visualising and analysing archaeological datasets in three dimensions.With platforms allowing archaeologists to link, query and analyse in a virtual, georeferenced space information collected by different specialists, the book highlights how it is possible to re-thin
