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Background: Orthostatic hypotension (OH) is a major sign of cardiovascular autonomic failure leading to orthostatic intolerance and syncope. Orthostatic hypotension is traditionally divided into classical OH (cOH) and delayed OH (dOH), but the differences between the two variants are not well-studied. We performed a systematic clinical and neuroendocrine characterization of OH patients in a tertia
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Euglossine bees are an ecologically important group, which due to their diverse resource needs act as pollinators of many neotropical plants. Male euglossines collect fragrant compounds used in mating displays from diverse sources, including the flowers of orchids and other plants. This aspect of euglossine biology has proven exceptionally useful for studies of euglossine bee populations, because
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Joint Species Distribution Modelling (JSDM) is becoming an increasingly popular statistical method for analysing data in community ecology. Hierarchical Modelling of Species Communities (HMSC) is a general and flexible framework for fitting JSDMs. HMSC allows the integration of community ecology data with data on environmental covariates, species traits, phylogenetic relationships and the spatio-t
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This contribution presents a novel process analytical technology (PAT) software interface for online monitoring and control of commercial high-pressure liquid chromatography (HPLC) systems. The developed interface is an add-on to chromatography control software and uses industry-standard bidirectional communication protocols to link sensor technologies with the individual HPLC system components in
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Adoptive cell therapy (ACT) with autologous tumor-infiltrating lymphocytes (TILs) can induce durable complete tumor regression in patients with advanced melanoma. Efforts are currently underway to expand this treatment modality to other cancer types. In the microenvironment of ovarian cancer, the engagement of co-inhibitory immune checkpoint molecules such as CTLA-4 can lead to the inactivation of