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Cancer invasion and metastasis are known to be potentiated by the expression of aquaporins (AQPs). Likewise, the expression levels of AQPs have been shown to be prognostic for survival in patients and have a role in tumor growth, edema, angiogenesis, and tumor cell migration. Thus, AQPs are key players in cancer biology and potential targets for drug development. Here, we present the single-partic
Implantable cell replacement therapies promise to completely restore the function of neural structures, possibly changing how we currently perceive the onset of neurodegenerative diseases. One of the major clinical hurdles for the routine implementation of stem cell therapies is poor cell retention and survival, demanding the need to better understand these mechanisms while providing precise and s
Cities are growing in size and becoming increasingly dense. This situation calls for strategic planning of green infrastructure in the urban planning process. Safeguarding the green infrastructure is important for maintaining urban ecosystem services and increasing the well-being of urban populations. To facilitate appropriate urban planning that enables cities to grow sustainably, it is important
Cardiovascular disease (CVD) development may be linked to persistent organic pollutants (POPs), including organochlorine compounds (OCs) and perfluoroalkyl and polyfluoroalkyl substances (PFAS). To explore underlying mechanisms, we investigated metabolites, proteins, and genes linking POPs with CVD risk. We used data from a nested case-control study on myocardial infarction (MI) and stroke from th
We report energy renormalizations from electron-phonon and electron-magnon interactions in spin minority surface resonances on Ni(111). The different interactions are identified, disentangled, and quantified from the characteristic signatures they provide to the complex self-energy and the largely different binding energies at which they occur. The observed electron-magnon interactions exhibit a s
This study aimed to contribute to knowledge about research on educational superintendents as decision-maker through a systematic review of research on this topic undertaken between 2000 and 2022. A literature search followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach. Of the 313 articles identified, 36 met the inclusion and quality criteria of the mixe
Obligately multicellular organisms, where cells can only reproduce as part of the group, have evolved multiple times across the tree of life. Obligate multicellularity has only evolved when clonal groups form by cell division, rather than by cells aggregating, as clonality prevents internal conflict. Yet obligately multicellular organisms still vary greatly in 'multicellular complexity' (the numbe
Driving automation systems, including autonomous driving and advanced driver assistance, are an important safety-critical domain. Such systems often incorporate perception systems that use machine learning to analyze the vehicle environment. We explore new or differing topics and challenges experienced by practitioners in this domain, which relate to requirements engineering (RE), quality, and sys
Despite decades of research on the pathophysiology of depression, the development of new therapeutic interventions has been slow, and no biomarkers of treatment response have been clinically implemented. Several lines of evidence suggest that the clinical and biological heterogeneity among patients with major depressive disorder (MDD) has hampered progress in this field. MDD with low-grade inflamm
Beijing's interest in the African continent is strong. For some time, China has been investing considerable capital to increase its influence in many sub-Saharan nations, often rich in raw materials and resources considered essential for Chinese industrial growth. In this respect, a very interesting case concerns Tanzania, a significant African state facing the Indian Ocean that has recently estab
BackgroundBacteraemia with species in the genus Campylobacter is rare, and knowledge of the disease course in comparison to Campylobacter enteritis is limited.MethodsThis is a retrospective population-based study. Episodes of Campylobacter bacteraemia, and Campylobacter enteritis with a concurrent negative blood culture, that occurred between 2015 and 2022 in southern Sweden were identified throug
Monitoring natural events at ultrafast timescales is a prerequisite for our continued understanding of physical, chemical and biological processes. Due to exponential advancements in knowledge and optical technology, the field of ultrafast videography has seen a sudden uptick in activity beginning in the mid-2010s. Today, the field has matured past its infancy and is slowly becoming a standard too
Students’ beliefs about division by zero and numbers on the number line werestudied through explanations of the concepts in questionnaires and interviewsduring their teacher education to become primary school teachers in the years4–6. The concepts were chosen for students’ proven cognitive challenges incoping with them, with the aim to add to the existing knowledge in terms ofspecific and general
A physics lecture and a mathematics lecture, by the same teacher and partly thesame students, were studied at upper secondary school. Both lectures coveredordinary differential equations. The main aim of the present paper was to investigate the teacher’s different and similar ways to handle related mathematicalcontent in the two school subjects. The findings show a structural use of mathematics wi
Humans are expert percievers of behavioural properties, including the timing of movements. Even short hesitancies and delays can be salient depending on the context. This article presents results from a pilot study on time delays in a human-robot interaction setting using the Wizard of Oz paradigm. Participants (n=17) played Tic-Tac-Toe with the humanoid robot Epi. They were randomized into one of
BackgroundCerebral small vessel disease can be identified using magnetic resonance imaging, and includes white matter hyperintensities, lacunar infarcts, cerebral microbleeds, and brain atrophy. Cerebral small vessel disease and chronic kidney disease share many risk factors, including hypertension. This study aims to explore an association between chronic kidney disease and cerebral small vessel
In Sweden, extensive use and the inherent heterogeneity of train traffic have significantly increased the sensitivity of the train system so that the delay of one train can easily propagate to others. Repeated experiences with train delays can lead passengers to perceive that railway transportation is unreliable. Despite being considered a green mode of transport, this environmental benefit truly
Vid utformning och dimensionering av såväl anläggningskonstruktioner som enskilda byggnadsdelar måste vanligtvis ett flertal olika belastningssituationer analyseras. Utöver statiska lastfall kan det vara nödvändigt att beakta dynamiska laster, såsom explosions- eller stötlast. För att påvisa tillräcklig bärförmåga används i allmänhet datorbaserade beräkningsmodeller, ofta framtagna med finita elemA structural design process typically involves various load cases for which a sufficient load-bearing capacity must be demonstrated. In addition to static load cases, a verification of dynamic loads, such as blast and impact loading, may be required. To this end, the response can be estimated using computational models representing an idealized structure, often formulated using the finite element
