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Autonomic computing systems are capable of adapting their behavior and resources thousands of times a second to automatically decide the best way to accomplish a given goal despite changing environmental conditions and demands. Different decision mechanisms are considered in the literature, but in the vast majority of the cases a single technique is applied to a given instance of the problem. This
In light of the emerging diabetes epidemic, new experimental approaches in islet research are needed to elucidate the mechanisms behind pancreatic islet dysfunction and to facilitate the development of more effective therapies. Optogenetics has created numerous new experimental tools enabling us to gain insights into processes little was known about before. The spatial and temporal precision that
The European Spallation Source (ESS) neutron spallation project currently being designed will be built outside of Lund, Sweden. The ESS design includes three helium cryoplants, providing cryogenic cooling for the proton accelerator superconducting cavities, the target neutron source, and for the ESS instrument suite. In total, the cryoplants consume approximately 7 MW of electrical power, and will
Objective: Cerebral accumulation of amyloid beta (A beta) is a pathological hallmark of Alzheimer's disease (AD). Proteolytic processing of amyloid precursor protein (APP) by alpha- or beta-secretase results in two soluble metabolites, sAPP alpha and sAPP beta, respectively. However, previous data have shown that both alpha- and beta-secretase have multiple cleavage sites. The aim of this study wa
A functional intracellular transport system is essential to maintain cell shape and function especially in elongated cells, e.g. neurons and lens fibre cells. Impaired intracellular transport has been suggested as a common pathological mechanism for age-related diseases characterised by protein aggregation. Here, we hypothesise that common genetic variation in the transport protein kinesin may inf
Swedish legislation requires that any owner or user of a building maintain a reasonable level of fire protection measures to ensure the safety of all people located in the building. If a building, in the wake of a fire, in court is determined not to have had a reasonable fire protection, the blame will likewise be assigned to the building owner or user. Using the perspective of risk governance, th
This study assessed seasonal and regional trends of pharmaceuticals and personal care products (PPCPs) detected in monthly samples from two local wastewater treatment plants (WWTPs) in Charleston, South Carolina, USA, over the period of one year. Surface water of Charleston Harbor was also analyzed to examine environmental distribution in an estuarine ecosystem. Of the 19 compounds examined, 11 we
Structure-activity experiments were performed for the HCl oxidation reaction (Deacon-like process) over RuO2 model catalysts - RuO2(1 1 0) and RuO2(1 0 0) - applying in situ surface X-ray diffraction (SXRD) combined with on-line mass spectrometry. The studied model catalysts turned out to be long-term stable under reaction conditions with gas feed ratios p(HCl):p(O-2) ranging from 1:4 to 4:1 in th
IDO1 can be induced by interferon gamma (IFN-γ) in multiple cell types. We have earlier described that the DNA methyltransferase inhibitor zebularine also induces IDO1 in several rat cell clones. We now describe a synergistic induction of IDO1 expression by IFN-γ and zebularine. To elucidate the mechanism of the IDO1 induction we have studied the methylation status in the promoter region of the ID
Insulin is released from pancreatic beta-cells as a result of Ca(2+)-evoked exocytosis of dense-core granules. Secretion is biphasic, which has been suggested to correspond to the release of different granule pools. Here we review and carefully reanalyze previously published patch-clamp data on depolarization-evoked Ca(2+)-currents and corresponding capacitance measurements. Using a statistical mi
Results are presented which indicate that high stem tones realizing word accents activate a certain class of suffixes in on-line processing of Central Swedish. This supports the view that high Swedish word accent tones are induced onto word stems by particular suffixes rather than being associated with words in the mental lexicon. Using Event-Related Potentials, effects of mismatch between word ac
The feasibility of sequential anaerobic-aerobic treatment for complete dye degradation was evaluated using three azo dyes, namely Remazol Red RR, Remazol Blue RR and Remazol Yellow RR. The robustness of the anaerobic treatment was investigated in biofilm reactors and the influences of carrier type, hydraulic retention time, dye concentration and dye type were studied. A decolourisation of 98% was
Lung transplantation (LTx) is a therapeutic option for patients with life-threatening chronic obstructive pulmonary disease (COPD) that is refractory to conventional therapies. The survival benefit of LTx for COPD is difficult to assess. The aim of this study was to evaluate the Swedish series of LTx performed to treat COPD and to identify differences in outcome between COPD related to severe alph
Three-dimensional (3-D) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) helps quantify biochemical changes in articular cartilage that correlate with early-stage osteoarthritis. However, dGEMRIC analysis is performed slice by slice, limiting the potential of 3-D data to give an overall impression of cartilage biochemistry. We previously developed a computational algorithm to produce unfolde
Background: Little is known about the development of excess skin and requests for body-contouring surgery after bariatric surgery in adolescents. Methods: Forty-seven of 86 adolescents that had undergone gastric bypass surgery answered two questionnaires regarding excess skin and requests for and performed body-contouring surgery. An objective assessment of the amount of excess skin was also perfo
Introduction: Acquired AmpC enzymes, classified as miscellaneous extended-spectrum beta-lactamase (ESBLM) enzymes according to a recently proposed beta-lactamase classification, are increasing according to several publications. Simple and rapid methods for detection of ESBLM are needed for appropriate infection control. A gel-based multiplex PCR method for acquired bla(AmpC) detection and subtype
This study highlights the fast recovery of the wintertime Siberian High intensity (SHI) over the last two decades. The SHI showed a marked weakening trend from the 1970s to 1980s, leading to unprecedented low SHI in the early 1990s according to most observational data sets. This salient declining SHI trend, however, was sharply replaced by a fast recovery over the last two decades. Since the decli
