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Vacuum-Assisted Closure Therapy after Cardiac Surgery. Sternal Stability, Cost of Care, Learning Curve and Hemodynamic Outcome

Deep sternal wound infection (DSWI) following cardiothoracic surgery is a rare but potentially life-threatening complication with high morbidity and mortality. DSWI is associated with a significant increase in the length of hospital stay and the cost of hospitalization. The socioeconomic impact of DSWI is considerable. Conventional treatment includes reexploration, surgical debridement, mediastin

Socio-Technical Toolbox for Business Analysis in practice

Socio-technical methods advocate a human-focus analysis that reflects on social and technical factors in the design of organizational systems. The aim of this paper is to report on the experiences of a ST toolbox use in practice by 36 companies. Our findings show that the use of ST toolbox improves companies’ understanding of their job practices and enhance their learning about their business sust

Modeling regional to global CH4 emissions of boreal and arctic wetlands

Methane (CH4) emission from boreal, arctic and subarctic wetlands constitutes a potentially positive feedback to global climate warming. Many process-based models have been developed, but high uncertainties remain in estimating the amount of CH4 released from wetlands at the global scale. This study tries to improve estimates of CH4 emissions by up-scaling a wetland CH4 emission model, PEATLAND-VU

Novel insights into the role of serotonin in control of β-cell fuction

Popular Abstract in Swedish Diabetes mellitus är en samling sjukdomar som karaktäriseras av förhöjt blodsocker. Traditionellt har man delat upp sjukdomen i två former; typ 1 och typ 2 diabetes. Vid typ 1 diabetes förstörs de insulinproducerande β-cellerna i bukspottskörteln av kroppens immunförsvar och sjukdomen debuterar ofta tidigt i livet. Typ 2 diabetes, tidigare ofta benämnd ”åldersdiabetes” Inadequate insulin secretion is a central component in the development of Diabetes Mellitus, resulting from reduced pancreatic β-cell mass, as well as diminished β-cell function. Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate insulin secretion and β-cell mass in rodents during pregnancy and in metabolically challenged states. However, the role of 5-HT in control of insulin rel

Review of comparative LCAs of food waste management systems - Current status and potential improvements.

Twenty-five comparative cycle assessments (LCAs) addressing food waste treatment were reviewed, including the treatment alternatives landfill, thermal treatment, compost (small and large scale) and anaerobic digestion. The global warming potential related to these treatment alternatives varies largely amongst the studies. Large differences in relation to setting of system boundaries, methodologica

HOST EPIGENETIC REGULATOR BMI1 AND VIRAL FIBER PROTEIN FOR EQUILIBRIUM BETWEEN ADENOVIRUS AND HOST

Popular Abstract in Swedish Adenovirus från människa (Ad) används ofta vid genterapi mot cancer, vaccinutveckling och genöverföring. Modifierade Ad5 och Ad2 virus har framgångsrikt använts som cancercelldödande (onkolytiska) agens i experimentella studier som dock inte kunnat överföras till kliniskt bruk av flera skäl, inklusive bristande spridning av virusinfektionen inom tumörvävnaden. De onkolyHuman adenoviruses (Ads) are broadly used in cancer gene therapy, vaccine development and gene delivery. The modified Ad5 or Ad2 viruses have been successfully used as oncolytic agents in pre-clinical studies. However they could not be translated into clinic utility due to a number of limitations including inefficient Ad spread among tumor cells. The cancer cell killing capacity of oncolytic Ad is

t(3;21)(q22;q22) leading to truncation of the RYK gene in atypical chronic myeloid leukemia

The analysis of a small number of patients with atypical chronic myeloid leukemia showing balanced chromosomal translocations has revealed diverse tyrosine kinase fusion genes, most commonly involving FGFR1, PDGFRA, PDGFRB, JAK2, and ABL. We present a case of aCML with a 3q22;21q22-translocation that led to truncation of the receptor-like tyrosine kinase (RYK) gene and its juxtaposition with seque

Role of NFAT (nuclear factor of activated T cells) in vascular smooth muscle

The calcium-dependent transcription factor NFAT was first described as a key player in immune cell regulation. Since then, NFAT signaling has been shown to be crucial for normal vascular development during embryogenesis. This pathway is also an important regulator of cell growth and differentiation in various cell types, however, the functional significance of NFAT in the vasculature is largely un

Gravoturbulent Planetesimal Formation: The Positive Effect of long-lived Zonal Flows

Recent numerical simulations have shown long-lived axisymmetric sub- and super-Keplerian flows in protoplanetary disks. These zonal flows are found in local as well as global simulations of disks unstable to the magnetorotational instability. This paper covers our study of the strength and lifetime of zonal flows and the resulting long-lived gas over- and underdensities as functions of the azimuth

Från ämbetsman till ämbetsbärare : förändringar speglade i anmälningar mot präster under tre brytningstider

Popular Abstract in Swedish Avhandlingen tar upp frågor om prästernas arbetsmiljö och deras roll och identitet. I inledningskapitlet framhölls att flera faktorer är viktiga för en undersökning om prästernas arbetsmiljö och för utformningen av prästrollen och prästidentiteten. Det omgivande samhället, de organisatoriska ramarna och de förväntningar som ställs på prästerna är några sådana faktorer, In this dissertation the work environment and the roles and identities of the clergy in the Church of Sweden are investigated. It is said in the first chapter that there are several factors influencing the work environment and that these factors are important for the formation of the roles and identities of the clergy. The surrounding society, the organization, and the expectations directed at the

In-vivo dark-field and phase-contrast x-ray imaging.

Novel radiography approaches based on the wave nature of x-rays when propagating through matter have a great potential for improved future x-ray diagnostics in the clinics. Here, we present a significant milestone in this imaging method: in-vivo multi-contrast x-ray imaging of a mouse using a compact scanner. Of particular interest is the enhanced contrast in regions related to the respiratory sys

Subgel transition in diluted vesicular DODAB dispersions

We have characterized the lipid chain freezing in dilute aqueous vesicle dispersions of the cationic lipid dioctadecyldimethylammonium bromide (DODAB) using wide and small angle X-ray scattering, solid state NMR, DSC, turbidity and density measurements. The lipids freeze in two steps. Above 40 degrees C the chains are fluid and the lipids are in a so-called liquid-crystalline state. When cooling b

Epidemiological studies of risk factors for injuries in an adult population

Popular Abstract in Swedish Dödligheten i skador i Sverige har under de senaste årtiondena minskat, en minskning som idag dock har planat ut. Antalet dödade i transportolyckor och i arbetsplatsolyckor i Sverige har minskat under de senaste 40 åren vilket kan ses som ett resultat av ett effektivt säkerhetsarbete. När det gäller fallolyckor så har däremot andelen som dör av sina skador ökat markant Injuries are often associated with long-term suffering and lowered functioning, and personal injuries impose a huge burden on medical care and health services in addition to the costs associated with impaired functional ability. Each year in Sweden, falling accidents are experienced by a third of those aged 60 or over and half of those aged 80 or over, while injuries from traffic accidents still a

Search for supersymmetry in events with photons, bottom quarks, and missing transverse momentum in proton-proton collisions at a centre-of-mass energy of 7 TeV with the ATLAS detector

A search has been performed for the experimental signature of an isolated photon with high transverse momentum, at least one jet identified as originating from a bottom quark, and high missing transverse momentum. Such a final state may originate from supersymmetric models with gauge-mediated supersymmetry breaking in events in which one of a pair of higgsino-like neutralinos decays into a photon

Search for new particles decaying to ZZ using final states with leptons and jets with the ATLAS detector in root s=7 TeV proton-proton collisions

A search is presented for a narrow resonance decaying to a pair of Z bosons using data corresponding to 1.02 fb(-1) of integrated luminosity collected by the ATLAS experiment from pp collisions at root s= 7 TeV. Events containing either four charged leptons (llll) or two charged leptons and two jets (lljj) are analyzed and found to be consistent with the Standard Model background expectation. Lowe