Background: Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expanded CAG repeat in the HD gene. Both excitotoxicity and oxidative stress have been proposed to play important roles in the pathogenesis of HD. Since no effective treatment is available, this study was designed to explore the therapeutic potential of erythropoietin (EPO), a cytokine that has been found

We present an investigation of the quasibinary systems CoIn3-xZnx and CoGa3-xZnx which were structurally characterized by X-ray diffraction experiments and, in the case of CoGa3-xZnx, additionally by neutron powder diffraction experiments. The limiting compositions were found to be x=0.81(2) and x=0.73(2) for COIn3-xZnx and CoGa3-xZnx, respectively. The isotypic binary compounds CoIn3 and CoGa3 cr

Directed and elliptic flow of pi(0) - decay photons in 158 A GeV Pb+Pb collisions has been studied near midrapidity in an analysis of data obtained with the photon spectrometer LEDA of the WA98 experiment at the CERN SPS. Preliminary results on the rapidity and transverse momentum dependence of the flow have been obtained for various centrality classes for p(T) > 0.2 GeV/c and 2.3 < y < 2.9. The r

A systems analysis approach was used to assess farmscale nutrient and trace element sustainability by combining full-scale field experiments with specific studies of nutrient release from mineral weathering and trace-element cycling. At the Ojebyn dairy farm in northern Sweden, a farm-scale case study including phosphorus (P), potassium (K), and zinc (Zn) was run to compare organic and conventiona

Neutrophils migrate to infected mucosal sites that they protect against invading pathogens. Their interaction with the epithelial barrier is controlled by CXC chemokines and by their receptors. This study examined the change in susceptibility to urinary tract infection (UTI) after deletion of the murine interleukin 8 receptor homologue (mIL-8Rh). Experimental UTIs in control mice stimulated an epi

This paper presents global high-level synthesis (HLS) approach which addresses the problem of synthesis of conditional behaviors under resource constraints. In proposed methodology, the conditional behaviors are represented by hierarchical conditional dependency graphs (HCDG) and synthesized using derived constraints programming (CP) models. Our synthesis methods exploit multicycle operations and

Direct electron transfer (DET) was shown between the heme containing enzyme theophylline oxidase (ThO) and the surface of both graphite and gold electrodes. As proof on graphite a steady state current for theophylline was recorded using the electrode modified with adsorbed ThO. The electrode showed a Michaelis–Menten-like response to theophylline with a detection limit of 0.2 mM and a Michaelis–Me

Road roughness is a major source of vehicle fatigue. To improve the understanding of vehicle durability, statistical methods are applied to characterise measured road profiles. Different statistical road models are used to generate corresponding synthetic road profiles. Vehicle fatigue is assessed utilising a simple quarter-vehicle model in combination with the Palmgren-Miner damage hypothesis, Ba

Abstract is not available

This study presents an editio princeps of an Arabic medical treatise attributed to the ninth century physician Qusta Ibn Luqa. The treatise is one of approximately fifty works on medicine attributed to Qusta. The edition is based on a unique manuscript preserved in codex Ayasofya 3724. The established text has been translated into English, commented upon and provided with indices of technical term

Hybrid systems have been made by taking an acrylic latex dispersion and slowly dropping an alkyd resin into the dispersion while stirring to achieve a solid content of 75–80%. The particle size distributions of alkyd droplets were studied with a laser diffraction instrument and the structure of the hybrid system in the liquid state has been studied by light microscopy. The hybrid system was define

Continues positive airway pressure (CPAP) is recommended for treatment of sleep apnoea (SA) in patients with congestive heart failure (CHF) but is not easily tolerated resulting in poor patient compliance. Mandibular advancement device (MAD) is designed to inhibit pharyngeal airway (PAW) obstruction and may be a valuable alternative. It has been proposed that MAD exerts its effect by increasing PA

The hindered diffusion and binding of proteins of different sizes (lysozyme, BSA and IgG) in an agarose gel is described using adsorption kinetic and diffusional data together with an experimentally determined pore size distribution in the gel. The validity of the pore model, including variable diffusion coefficients and porosities is tested against experimental confocal microscopy data. No fittin

A computer program for evaluating colour factors of QCD Feynman diagrams is presented, and illustrative examples on how to use the program to calculate nontrivial colour factors are given. The program and the discussion in this paper is based on a diagrammatic approach to colour factors.

BEAST is a Bidirectional Efficient Algorithm for Searching code Trees. In this paper, it is used for decoding block codes over the additive white Gaussian noise (AWGN) channel. If no constraints are imposed on the decoding complexity (in terms of the number of visited nodes during the search), BEAST performs maximum-likelihood (ML) decoding. At the cost of a negligible performance degradation, BEA

The high-resolution far-infrared spectrum of the intermolecular HC1 libration band v(4)(1) of the OC-H(35)C1 heterodimer is recorded in the gas phase by means of Fourier transform IR spectroscopy in a static multipass absorption cell at 137 K using a synchrotron radiation source. This is the first direct observation of an intermolecular vibration band of the OC-HC1 dimer in the gas phase. The rota