For patients with end-stage respiratory diseases, such as COPD, interstitial lung diseases and cystic fibrosis, lung transplantation remains the only treatable option. However, due to increasing demand and limited availability of donor lungs, risk of complications such as acute and chronic rejection, and adverse effects of immunosuppressive treatments, this is not an alternative for the majority o

The expression and functional impact of most expression orphan G-protein coupled receptors (GPCRs) in β-cell is not fully understood. Microarray expression indicated that 36 orphan GPCRs are restricted in human islets, while 55 receptors overlapped between human islets and INS-1 cells. GPR183 showed higher expression in diabetic compared to non-diabetic human islets. GPR183 expression co-localized

Human Aquaporin 2 (AQP2) is a membrane-bound water channel found in the kidney collecting duct whose regulation by trafficking plays a key role in regulating urine volume. AQP2 trafficking is tightly controlled by the pituitary hormone arginine vasopressin (AVP), which stimulates translocation of AQP2 residing in storage vesicles to the apical membrane. The AVP-dependent translocation of AQP2 to a

Composite adaptive control schemes, which use both the system tracking error and the prediction error to drive the updating law, have become widespread in achieving an improvement of system performance. However, a strong persistent-excitation (PE) condition is required to guarantee the convergence of the parameter estimation errors. This paper proposes a novel composite adaptive control for nonlin

We investigated the duration of suppression-induced forgetting (SIF), and the extent to which retrieval suppression differs between negative and neutral memories. We further examined if SIF was differently affected by sleep versus wake during the delay interval between retrieval suppression and re-test. Fifty participants first learned to associate neutral words with either neutral or negative ima

The aim of this explorative study is to examine the theoretical and empirical notions in the business model of innovation that are influenced by use of management control systems (MCS). By means of a systematic literature review, the theoretical constructs are highlighted and related to the diagnostic and interactive uses of part of the MCS, namely the performance measurement systems (PMS), and thThe aim of this explorative study is to examine the theoretical and empirical notions in the business model of innovation that are influenced by use of management control systems (MCS). By means of a systematic literature review, the theoretical constructs are highlighted and related to the diagnostic and interactive uses of part of the MCS, namely the performance measurement systems (PMS), and th

Describing the motion in a vertical roller coaster loop requires a good understanding of Newton's laws, vectors and energy transformation. This paper describes how first-year students try to make sense of force and acceleration in this example of non-uniform circular motion, which was part of a written exam. In addition to an analysis of the exam solutions by about 60 students, a group interview w

that are influenced by use of management control systems (MCS). By means of a systematic literature review, the theoretical constructs are explored and related to part of the MCS, namely the performance measurement systems (PMS) and the business model of innovation (i.e. innovation input, process, output, and outcome). The results of the systematic literature review will be used to develop a set o

The Circumpolar North has been changing rapidly within the last decades, and the socioeconomic systems of the Eurasian Arctic and Siberia in particular have displayed the most dramatic changes. Here, anthropogenic drivers of environmental change such as migration and industrialization are added to climate-induced changes in the natural environment such as permafrost thawing and increased frequency

The interplay between innovation and measurement has fascinated scholars from several disciplines over the last decade. All these diverse contributions, however, have resulted in a current state of knowledge that is signified by large numbers of articles without clear integration and synthesis. Therefore the aim of this explorative thesis is to examine the theoretical and empirical notions of inno

Objective: Higher gluten intake, frequent gastrointestinal infections and adenovirus, enterovirus, rotavirus and reovirus have been proposed as environmental triggers for coeliac disease. However, it is not known whether an interaction exists between the ingested gluten amount and viral exposures in the development of coeliac disease. This study investigated whether distinct viral exposures alone

Fungi play many essential roles in ecosystems. They facilitate plant access to nutrients and water, serve as decay agents that cycle carbon and nutrients through the soil, water and atmosphere, and are major regulators of macro-organismal populations. Although technological advances are improving the detection and identification of fungi, there still exist key gaps in our ecological knowledge of t

As a result of the huge economic and industrial development that human has been experiencing for decades or centuries, there are millions of potentially contaminated sites around the globe. Potentially contaminated sites are those which industrial, agricultural, mining and waste containment activities with potential to contaminate soil and groundwater has taken place in. A small number of these co

Background and purpose — Obesity defined as increased BMI is commonly associated with higher revision rates following total knee arthroplasty (TKA). We examined the effect of BMI on the rate of revision after TKA, for both infection and other reasons, and analyzed weight and height separately to provide better understanding of the risk profile. Patients and methods — The Swedish national knee arth

Objectives. The aim of this study was to investigate endothelium dependent relaxation (EDR) in coronary artery and the myocardial contractility after 24 h of non-ischemic heart preservation (NIHP). Design. Explanted cardioplegic hearts from six pigs were preserved by NIHP for 24 h. The perfusion medium consisted of an albumin containing hyperoncotic cardioplegic nutrition-hormone solution with ery

Failures in Alzheimer's disease (AD) drug trials highlight the need to further explore disease mechanisms and alterations of biomarkers during the development of AD. Using cross-sectional data from 377 participants in the BioFINDER study, we examined seven cerebrospinal fluid (CSF) and six plasma biomarkers in relation to β-amyloid (Aβ) PET uptake to understand their evolution during AD. In CSF, A