The autoimmune checkpoint during B cell maturation eliminates self-antigen reactive specificities from the mature B cell repertoire. However, an exception to this rule is illustrated by B-1 cells, an innate-like self-reactive B cell subset that is positively selected into the mature B cell pool in a self-antigen-driven fashion. The mechanisms by which B-1 cells escape central tolerance have puzzle

BACKGROUND: The transradial approach is associated with fewer bleeding complications during percutaneous coronary interventions (PCIs) but is more technically challenging and associated with prolonged times during intervention. The aim of this study is to retrospectively compare the results of radial vs. femoral approach in patients >or=80 years old undergoing primary or rescue PCI.METHODS: Betwee

A small-scale experiment for salinity-gradient solar pond has been constructed and operated at the Dead Sea area over a period of 3 months. The pond has a volume of 5m3 with dimensions of (L, H, W) as 2.0, 2.0 and 1,25 meter respectively. The two parameters temperature and salinity concentration profiles were evaluated through the measurements of the solar pond with respect to time. The experiment

We provide a brief overview of the educational history of Denmark and document archival and printed sources covering the development of primary, secondary, and tertiary education. In particular, we focus on student grade lists, which are available for individuals at all levels of education from the early nineteenth century until well into the twentieth century. We suggest that these can be used to

This doctoral thesis consists of four independent research papers. All papers are empirical and cover the area of financial market risk, with a particular focus on systemic risk and volatility in financial markets.The first paper analyzes the joint effect of centrality and other characteristics that are essential in determining banks’ systemic importance. Specifically, centrality is treated as a m

The dissolution of Yugoslavia in the nineties brought a series of armed conflicts, civil wars and outright war to the Balkan Peninsula. The Serbian Orthodox Church (SOC) was entangled in these conflicts. The SOC’s involvement in these wars has sparked an academic discussion about the role of religion, especially that of the SOC, in these conflicts. This discussion has so far mainly been social sci

In contemporary Serbian Orthodox texts, Kosovo is often referred to as the Serbian “Jerusalem”: a city calling for a Christian defense. All Serbs are bound to heed the call in keeping with the Kosovo “covenant” or “pledge” dating back to the Battle of Kosovo Polje in 1389, when Serbian troops, led by Prince Lazar, were defeated by the invading Muslim Ottoman army. The battle and Kosovo in general

Mount Lovćen holds significant cultural, political and religious symbolism in Montenegro, especially due to the fact that the mountain is the last resting place of the prince-bishop and national poet Petar II Petrovich-Njegoš (1813–1851). In the twentieth century the grave of Njegoš has undergone profound material transformations. Each of these transformations has led to heated debates about the s

The new European state Montenegro has been a scene for an internal ecclesial strife between the Serbian Orthodox Church and the newly formed Montenegrin Orthodox Church since the early nineties. This article focuses on the ecclesiological models used in the discussion between the two churches. On one side the Montenegrin Church understands itself from the classical juridical "eusebian" church mode

Miranda Frickers Epistemic Injustice (2007, i svensk översättning Epistemisk orättvisa, Thales 2018) gav upphov till en filosofisk diskussion om en förbisedd specifik form av orättvisa: att inte betraktas som kunnig eller trovärdig, att exkluderas från epistemiska praktiker på grund av vem man är eller anses vara. Denna epistemiska marginalisering är en komponent av social orättvisa i allmänhet oc

Due to their stable fluorescence, biocompatibility, and amenability to functionalization, fluorescent nanodiamonds (FND) are promising materials for long term cell labeling and tracking. However, transporting them to the cytosol remains a major challenge, due to low internalization efficiencies and endosomal entrapment. Here, nanostraws in combination with low voltage electroporation pulses are us

Denna 'Scandia utblick' diskuterar historiska perspektiv på 1970-talet med utgångspunkt i både svensk och internationell forskning.