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Leucine increases muscle mitochondrial respiration and attenuates glucose intolerance in diet-induced obesity in Swiss mice

Leucine is an essential amino acid that has been investigated by its participation in the regulation of whole-body metabolism and mitochondrial function. Here, we evaluated acute leucine effects on mitochondrial respiration of skeletal muscle from male Swiss mice in vitro. Additionally, we further investigated the effects of 4-wk leucine ingestion (2.5% on drinking water) on skeletal muscle mitoch

Decrement in resting and insulin-stimulated soleus muscle mitochondrial respiration is an early event in diet-induced obesity in mice

New Findings: What is the central question of this study? What are the temporal responses of mitochondrial respiration and mitochondrial responsivity to insulin in soleus muscle fibres from mice during the development of obesity and insulin resistance? What is the main finding and its importance? Short- and long-term feeding with a high-fat diet markedly reduced soleus mitochondrial respiration an

Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal

Diabetes impacts on brain metabolism, structure and function. Alterations in brain metabolism have been observed in obesity and diabetes models induced by exposure to diets rich in saturated fat and/or sugar and have been linked to memory impairment. However, it remains to be determined whether brain dysfunction induced by obesogenic diets results from permanent brain alterations. We tested the hy

”Under konungens enskilda styrelse” : Statschefen, kungahuset, hovet och ordensväsendet i konstitutionellt och rättshistoriskt perspektiv

Boken är en rättshistorisk utredning utförd åt Förtjänstutredningen och utgör en bilaga till SOU 2021:74. I texten finns en historisk översikt över statschefens funktion och ställning, särskilt vad gäller övergången från 1809 års till 1974 årsregeringsform. Vidare behandlas kungahuset och några liknande begrepp samt successionsrätten och husmakten. Tyngdpunkten ligger på en analys av den historisk

Meet Esmaeil Khatib, Iran’s New Spymaster

The new president of the Islamic Republic of Iran, Ebrahim Raisi, has selected cleric Esmail Khatib as Minister of Intelligence. Khatib is a radical Islamist with close ties to both Supreme Leader Ali Khamenei and the Islamic Revolutionary Guard Corps. During his tenure, we can expect a more aggressive approach by the Ministry of Intelligence, meaning more terrorism and violence at the hands of th

Sintering Mechanism of Core@Shell Metal@Metal Oxide Nanoparticles

Metal oxide shell layers are promising candidates to improve the performance of metal nanoparticles (NPs) in various applications. However, despite a significant amount of experimental work on metal@metal oxide (M@MO) NPs, computational modeling is scarce, particularly on the sintering mechanism, which plays a crucial role in both the synthesis and performance of NPs. Here, we present atomic diffu

Re-making Domestic Natures. Multispecies Life and Care at the Sanctuary

What images of multispecies life might emerge from the practices of sanctuary-caregiving in a time of anthropogenic extinction and environmental degradation? In this presentation, I will delve into the embodied, situated, and multispecies care practices unfolding within the everyday context of farmed animal sanctuaries. ...

Challenging Law’s Hegemonic Regimes of Care: Perspective on Farmed Animal Sanctuaries

Over the past decades, Farmed Animal Sanctuaries (FAS) have emerged globally to become a significant part of the broader animal movement. However, FASes are confronted with the difficult task of providing life-long care for animals bred for profit within a normative regime intended on industrial production. Based on multi-sited fieldwork performed in Denmark, this paper examines critical barriers

Video feedback combined with coordination meetings in school to reduce early disruptive behaviour problems (DBP)—A 1-year follow-up randomised controlled trial

Aim: To compare long-term effects of a systemic school-based intervention, Marte Meo and Coordination Meetings (MAC), targeting 3- to 12-year-old children display- ing disruptive behaviour problems (DBP) in preschool or school, and service as usual (SAU). In addition, to examine whether social status (SS) affected the outcomes. Methods: In a randomised controlled design, teachers' and parents' ratAim: To compare long-term effects of a systemic school-based intervention, Marte Meo and Coordination Meetings (MAC), targeting 3- to 12-year-old children display- ing disruptive behaviour problems (DBP) in preschool or school, and service as usual (SAU). In addition, to examine whether social status (SS) affected the outcomes. Methods: In a randomised controlled design, teachers' and parents' rat