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Background/Objectives: Mitochondrial dysfunction is a major cause of brain injury in patients with primary mitochondrial disease. New mitochondrial therapeutics and non-invasive tools for efficacy monitoring are urgently needed. To these ends, succinate prodrug NV354 (methyl 3-[(2-acetylaminoethylthio)carbonyl]propionate) and diffuse optical techniques are promising. In this proof-of-concept study
Smart microscopy represents a paradigm shift in biological imaging, moving from passive observation tools to active collaborators in scientific inquiry. Enabled by advances in automation, computational power, and artificial intelligence, these systems are now capable of adaptive decision-making and real-time experimental control. Here, we introduce a theoretical framework that reconceptualises sma
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are rare autoimmune diseases, including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophil granulomatosis with polyangiitis (EGPA). They are three distinct diseases with overlapping symptoms and signs. The ANCAs involved in AAV are mainly directed against myeloperoxidase (MPO) and proteinase
Context. Neutron-capture elements are believed to make up almost all elements heavier than iron in the periodic table. By studying the abundance of these elements throughout the Galaxy, it is possible to put constraints on how and where neutron-capture processes occur. Determining elemental abundances is made possible through the correct interpretation and modelling of astrophysical spectra. Key i
To facilitate a simultaneous treatment of an arbitrary number of colors in representation theory-based descriptions of QCD color structure, we derive an N-independent reduction of SU(N) tensor products. To this end, we label each irreducible representation by a pair of Young diagrams, with parts acting on quarks and antiquarks. By combining this with a column-wise multiplication of Young diagrams,
Aims: Drug–gene interactions (DGIs) modify drug response and safety, yet their influence on diabetic microvascular complications remains unclear. This study aimed to elucidate the role of DGIs in these complications. Materials and Methods: Using UK Biobank (UKB) data, we identified medications frequently prescribed to individuals with diabetes and defined DGIs based on the Food and Drug Administra
Den här rapporten undersöker hur Sölvesborgs kommun kan stärka hållbar mobilitet och samtidigt använda centrala ytor mer effektivt genom att etablera mobilitetshubbar. En mobilitetshubb kan beskrivas som en samlad nod där flera färdmedel och tjänster möts: cykelparkering, laddning, bilpool, lånecyklar, information, bokning och möjligheter att byta mellan gång, cykel, buss och tåg. I stället för at
BackgroundChronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are characterized by persistent airway inflammation and airflow limitation. Measuring airway inflammation may be of value both in research and clinical practice. Calprotectin, a protein associated with neutrophil activation, serves as a potential biomarker for airway inflammation. This study evaluates the performance o
This editorial introduces Volume 33 (2025) of Current Swedish Archaeology, foregrounding archaeology as a socially embedded and politically implicated practice. The issue centers on contemporary challenges posed by rising anti-democratic and authoritarian forces and explores how archaeology and cultural heritage can contribute to sustainable, just, and resilient societies. The keynote by Marte Spa
Background Patients with acute coronary syndrome (ACS) are often admitted to monitored wards due to the risk of complications. Several risk prediction scores exist, but their use in the emergency department (ED) is limited. We aimed to compare the ability of existing risk scores with a new logistic regression model in predicting complications in ACS patients. Methods This was a secondary analysis
INTRODUCTION: Child stunting, a measure of malnutrition, is a major global health challenge affecting 148.1 million children in 2022. Global stunting rates have declined from 47.2% in 1985 to 22.3% in 2022; however, trends before the mid-1980s are unclear, including whether child stunting was previously prevalent in current high-income countries (HICs). We conducted a systematic review of child gr
Hypothalamic inflammation underlies diet-induced obesity and diabetes in rodent models. While diet normalization largely allows for recovery from metabolic impairment, it remains unknown whether long-term hypothalamic inflammation induced by obesogenic diets is a reversible process. In this study, we aimed at determining sex specificity of hypothalamic neuroinflammation and gliosis in mice fed a f
PURPOSE:Among available tumour necrosis factor inhibitors (TNF-inhibitors) only etanercept is approved for treatment of children with polyarticular course juvenile arthritis. Nevertheless also infliximab and adalimumab are used in selected cases, especially in patients having failed on etanercept.The objective was to evaluate adherence to therapy (a combined measure of efficacy and side effects as
