Filtyp
Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which encodes a Janus kinase with critical roles in type-Ι interferon (IFN-Ι) mediated intracellular signalling. To study the role of TYK2 in β-cell development and response to IFNα, we generated TYK2 knockout human iPSCs and directed
Removal of carbon dioxide from the atmosphere will be required over the next decades to achieve the Paris Agreement goal of limiting global warming to well below 2°C aiming at not exceeding 1.5°C. Technological and ecosystem-based options are considered for generating negative emissions through carbon dioxide removal (CDR) and several nations have already included these in their Long-Term Low Gree
This study investigates possible structural changes of an intrinsically disordered protein (IDP) when it adsorbs to a solid surface. Experiments on IDPs primarily result in ensemble averages due to their high dynamics. Therefore, molecular dynamics (MD) simulations are crucial for obtaining more detailed information on the atomistic and molecular levels. An evaluation of seven different force f
It is well-known that an increasing proportion of proteins, protein regions, and partners of globular proteins are being recognized as having an intrinsic disorder, and therefore, not adopting a single three-dimensional structure in solution. For these proteins, small-angle X-ray scattering (SAXS) has become a premier method for examination, since it can provide information about the ensemble of t
Glycolipids such as gangliosides affect the properties of lipid membranes and in extension the interactions between membranes and other biomolecules like proteins. To better understand how the properties of individual lipid molecules can contribute to shape the functional aspects of a membrane, the spatial restriction and dynamics of C–H bond segments can be measured using nuclear magnetic re
Plasmodium falciparum malaria can cause severe anemia. Even after treatment, hematocrit can decrease. The role of autoantibodies against erythrocytes is not clearly elucidated and how common they are, or what they are directed against, is still largely unknown. We have investigated antibodies against erythrocytes in healthy adult men living in a highly malaria endemic area in Uganda. We found anti
1 BACKGROUNDWeak expression of ABO antigens is encountered in the clinical laboratory occasionally, and subgroups of A are more commonly observed in Europeans than subgroups of B. To date, weakly expressing B variant phenotypes have been associated with 38 different alleles according to ISBT (https://www.isbtweb.org/resource/001aboalleles.html). This number is an underrepresentation since there ha
BACKGROUND AND OBJECTIVES: Under the ISBT, the Working Party (WP) for Red Cell Immunogenetics and Blood Group Terminology is charged with ratifying blood group systems, antigens and alleles. This report presents the outcomes from four WP business meetings, one located in Basel in 2019 and three held as virtual meetings during the COVID-19 pandemic in 2020 and 2021.MATERIALS AND METHODS: As in prev
Migration includes re-starting and re-building a life course. It begins with re-imagination of the journey and the kind of life that is going to take shape in the receiving society. One steps in a migratory journey with knowledge of the past experiences of dealing with risks through, among others, developing an understanding about one’s body. With migration, bodies get displaced, emplaced, replace
We have investigated how a de novo cohort of people with Parkinson’s disease (PD) differs in terms of balance and gait function as well as frequency of near falls and falls in comparison to a cohort with mild to moderate PD that has been medicated for several years. Preliminary results (Table 1) showed that people with de novo PD have balance and gait impairments and that some have also experience
Det övergripande syftet med denna licentiatavhandling är att öka kunskapen kring vad som påverkar att jobba som en brandman vars huvudsakliga sysselsättning är utanför räddningstjänsten (exempelvis frivilliga brandmän eller deltidsbrandmän) för att förstå hur utmaningar och engagemang påverkar beslutet att fortsätta vara verksam. Bibehållandet av dessa brandmän är en välkänd utmaning i många ländeThe overarching aim of this licentiate thesis is to increase knowledge about the implications of working as a non-career firefighter in order to understand how challenges and commitment affect retention. Retention of non-career firefighters (for example volunteer or part-time firefighters) is a well-known, multifaceted challenge in several countries. These non-career firefighters account for the m
This chapter explores discourses of exceptionalism, their embeddedness in particular contextual landscapes, exclusions, and transnational circulations across the global North, East and South. Based on a conversation between the authors around the ways in which national exceptionalism is articulated in three seemingly different landscapes – Scandinavian countries, Russia, and Turkey – the chapter h
This paper explores the case of Barents Pride, an event organized collaboratively byRussian and Norwegian LGBT+ activists located close to the Norwegian–Russian border. The idea of the Pride is to bring LGBT+ people and activists from Russia, where state pressure limits possibilities of organizing prides, to Norway and to express solidarity across borders. We use this case to investigate pitfalls
While scholars have shown the significance of transnational exchanges for shaping feminist and LGBTI+ connectivities across borders to challenge national exclusions and global divides, less attention has been directed at exploring the complex and ambiguous ways in which transnational collaborations and cross-border exchanges also may facilitate and support national agendas. That is what this artic
This article argues that there are observable similarities between the way ancient heresiologists depicted their theological opponents and how religious people and religion as a phenomenon are described by contemporary anti-religion orators. The short study takes its departure from previous studies on the Nag Hammadi texts and ancient heresiological discourse and ends with reflections on the
Renal dysfunction is a major risk factor for premature death and has been studied extensively. A new renal syndrome, shrunken pore syndrome (SPS), confers higher mortality in all studied populations. SPS is a condition in which cystatin C-based estimation of glomerular filtration rate (eGFRcystatin C) is ≥ 60% than creatinine-based estimation of glomerular filtration rate (eGFRcreatinine). We aime
