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Background: Inhaled nanomaterials can translocate from the lungs into systemic circulation and reach the liver, which is the main secondary organ for nanomaterial uptake, potentially causing adverse effects. Understanding how inhaled nanomaterials localize within liver tissue is important for understanding their clearance mechanisms and potential toxicity. Previous in vivo studies have primarily f
Correlated electron physics is intrinsically a multiscale problem, since high-energy electronic states screen the interactions between the correlated electrons close to the Fermi level, thereby reducing the magnitude of the interaction strength and dramatically shortening its range. Thus the handling of screening is an essential ingredient in the first-principles modeling of correlated electron sy
By combining ab initio downfolding with cluster dynamical mean-field theory, we study the degree of correlations in monolayer, bilayer, and bulk breathing-mode kagome van der Waals materials Nb3(F, Cl, Br, I)8. Our new material-specific many-body model library shows that in low-temperature bulk structures the Coulomb correlation strength steadily increases from I to Br, Cl, and F, allowing us to i
Acquired von Willebrand syndrome (AVWS) is a rare condition characterized by an acquired functional and/or absolute deficiency of the von Willebrand factor (VWF) protein. The absence of widely accepted diagnostic criteria has hampered accurate estimates of incidence and prevalence, which are largely currently unknown. As bleeding symptoms are not included in the most widely used definitions, AVWS
Across different domains, justice is considered either from a perspective concerning mind-independent features of a situation or from a perspective related to mind-dependent motives, traits or emotions. Although these approaches have generated valuable insights, they remain largely disconnected from each other. What is missing is an integrative framework that can explain how the objective features
Investigation of the properties of membrane proteins (MPs) is essential to the successful development of medicines and biotechnology. However, their study is often complicated by denaturation caused by the use of detergents during conventional extraction methods. Copolymers of styrene and maleic acid (SMA) have shown promise in extracting MPs directly from cells while reconstituting lipid mem
Lignin, a structurally intricate and heterogeneous phenolic biopolymer, holds considerable promise as a sustainable alternative to petrochemical-derived materials across diverse applications in the energy and materials sectors. However, precise lignin molecular weight and structure determination remains challenging due to its intrinsic tendency to aggregate in solution and the absence of chem
During the last decade or so, most aspects of world politics have become saturated with digital-technological devices and platforms such as smartphones and social media. Yet, practice-oriented International Relations (IR) scholarship has not adequately accounted for the profound impact of this technological transformation on how world politics is ‘done’ within, across and beyond the traditional in
Purpose: To evaluate a new analytical estimator for R1 and apparent proton density (𝐴) from short-TR dual flip angle data which does not rely on the small flip angle approximation and can thus be applied to a broader range of data, especially where relatively large flip angles are needed to achieve sufficient T1-weighting for R1 estimation.Theory and Methods: A rational approximation of the Ernst
BACKGROUND: Minimally invasive surgery is rapidly expanding globally, yet there is insufficient knowledge of how to scale this technology safely and equitably across diverse health systems. We aimed to identify health-system factors associated with safe implementation of minimally invasive surgery globally, using minimally invasive cholecystectomy as a tracer procedure.METHODS: We conducted a mult
The writings of the Austrian novelist and essayist Robert Musil provide sociology with vital problems and reflections. Indeed, Musil, not least in the novel The Man without qualities, introduces discussions that extend conventional and recurrent understanding of modernity – sociology’s general object of analysis. The paper focuses on three major sets of questions in Musil’s work: 1) the shapelessnThe writings of the Austrian novelist and essayist Robert Musil provide sociologywith vital problems and reflections. Indeed, Musil, not least in the novel The Manwithout qualities, introduces discussions that extend conventional and recurrentunderstanding of modernity – sociology’s general object of analysis. The paperfocuses on three major sets of questions in Musil’s work: 1) the shapelessness
This presentation offers an outline of classical modern reflection (sociology, cultural theory, literature) on the constitution and transformation of modernity, its cultural and mental dispositions. The discussion focuses on key themes and experiences of classical modernity: void, crisis and abundance. It is argued that classical modernity may be conceived as a conceptual archive of influential id
Purpose: The aim of this study was to evaluate the feasibility and mid-term results of combining polytetrafluoroethylene (PTFE)-based iliac limbs, having a short dilator tip, with a polyester (Dacron)-based bifurcated component during a fenestrated endovascular aortic repair (FEVAR).Materials and methods: All patients who underwent a FEVAR procedure in a single tertiary center were screened for in
Chickenpox is a highly contagious viral infection caused by varicella-zoster virus (VZV) whose clinical manifestations mimic mpox posing challenges for diagnosis without laboratory confirmation. Here, we investigated VZV among the mpox-suspected cases, May to October 2022, in Ethiopia. Samples were collected from 202 mpox-suspected cases in 11 of Ethiopia’s 14 regions and screened for mpox virus b
Para Alpine skiing is one of the largest sports at the Paralympic Winter Games. Recent studies report high injury rates in this sport. However, limited evidence exists regarding sport-specific injury characteristics, which is essential for targeted prevention. The aim of this study was to describe the overall incidence proportion and incidence of injuries reported by athletes participating in Alpi
