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Clots of 1 ml venous blood formed in glass tubes after 10 min at room temperature were incubated at 37°C with the radiopharmaceutical to be studied. Methods for quality control of the radiopharmaceuticals were compared. Gel chromatography scanning was found to give reliable information. The incorporation into the clot was studied at different pH values and after various time intervals. The highest
No Abstract
One major problem in microwave-induced clinical hyperthermia treatment of superficial tumours is to obtain therapeutic temperatures at the tumour periphery and adequate deep heating when using a single applicator. The use of multiple applicators has therefore been investigated in order to improve the power distribution. Anatomical surface topography often permits the application of two tilted appl
Regional blood flow in rat liver and in inoculated liver tumors was studied before, during and after local hyperthermia treatment at 42.0°C for one hour. Hyperthermia was induced by microwave irradiation of the central liver lobe. The method used for blood flow studies was the clearance of Xenon-133 following portal and intraparenchymal injection. The wash-out curves were analyzed by using a bi-ex
The uptake of97Ru-transferrin (Ru-TF) in tumor and abscess bearing animals was compared with67Ga-citrate (Ga),123I-transferrin (I-TF), and several other plasma proteins. Maximal concentration in tumor of Ru-TF in mice was three times higher than67Ga-citrate (16.80±4.20 vs 5.08±0.58% D/g) although it occurred later (24 h compared with67Ga which reached its maximum 2 h after injection). Whole body a
The blood flow in rat liver was measured with Xe-133. Three techniques for administering the activity to the liver were employed: injection via the portal vein, via the hepatic artery, and directly into the liver parenchyma. Use of intraparenchymal injection of Xe-133 gave 60% higher flow values than by portal or arterial injection techniques. Mean flow index (k1) was for portal injection 0.52, fo
A computerized system for inducing total body hyperthermia by microwave irradiation was tested in rats. The tolerance to hyperthermia at different temperatures and fractions was studied as well as its effect on the growth of transplanted adenocarcinomas in the liver. Survival results indicated that 41.5 degrees C was maximum tolerated temperature both after single and repeated one hour exposures.
Popular Abstract in Swedish Hjärnan består av hjärnbarken, även kallad den grå substansen, och den underliggande vita substansen. Den grå substansen med alla nervceller svarar bland annat för våra kognitiva funktioner som gör var och en av oss till unika individer. Medvetande, minne, språk och tal liksom ilska och glädje är alla exempel på egenskaper och funktioner som styrs från den grå substanseAlzheimer's disease (AD) is the most prevalent type of dementing disorder. The cortical pathology of AD has been recognized for almost a century. In later years, an associated pathological feature of AD has been identified which affects the white matter. This white matter disease (WMD), defined in the microscope, consists of a subtotal tissue loss of the white matter structural components. WMD is
Biotinylated small unilamellar liposomes were affinity partitioned in an aqueous poly(ethylene glycol)-dextran two-phase system using avidin coupled to dextran as affinity ligand. In the absence of affinity ligand more than 90% of the liposomes partitioned in the poly(ethylene glycol)-rich top phase, whereas in its presence more than 95% partitioned in the dextran-rich bottom phase. For this redis
Motivation: Pre-processing of SELDI-TOF mass spectrometry data is currently performed on a largel y ad hoc basis. This makes comparison of results from independent analyses troublesome and does not provide a framework for distinguishing different sources of variation in data. Results: In this article, we consider the task of pooling a large number of single-shot spectra, a task commonly performed
A direct search has been made for magnetic monopoles produced in e(+)p collisions at a centre of mass energy of 300 GeV at HERA. The beam pipe surrounding the interaction region in 1995-1997 was investigated using a SQUID magnetometer to look for stopped magnetic monopoles. During this time an integrated luminosity of 62 pb(-1) was delivered. No magnetic monopoles were observed and charge and mass
Electron paramagnetic resonance (EPR) spectroscopy is one of the major techniques used to analyse the structure and function of the water oxidising complex (WOC) in Photosystem II. The discovery of an EPR signal from the S0 state has opened the way for new experiments, aiming to characterise the S0 state and elucidate the differences between the different S states. We present a review of the bioch
The evidence for a relationship between life history and immune defense is equivocal, although the basic premise is intuitively appealing: animals that live short lives and reproduce early and rapidly should not waste resources on defenses they might never use. One possible reason for a lack of strong support for this hypothesis could be the inherent complexity of the vertebrate immune system. Ind
The membrane glycoproteins (Gn and Gc) of Bunyamwera virus (BUN, family Bunyaviridae) contain three potential sites for the attachment of N-linked glycans: one site (N60) on Gn and two (N624 and N1169) on Gc. We determined that all three sites are glycosylated. Digestion of the glycoproteins with endo-beta-N-acetylglucosaminidase H (endo H) or peptide:N-glycosidase F revealed that Gn and Gc differ
Stationary phases, to be used in high-performance liquid chromatography, were tailor-made for the separation of amino acids, peptides and proteins. The stationary phases were prepared by molecular imprinting, applying two different approaches. Low-molecular-mass compounds were imprinted in bulk polymers by copolymerization of functional monomers and cross-linkers in the presence of the compound of
Popular Abstract in Swedish Denna avhandling har bidragit med systematisk information om hur personer med schizofreni lever sitt vardagsliv, och resultaten har visat på signifikanta relationer mellan ett aktivitetsperspektiv och hälsa. Avhandlingen består av fem studier. De första två är kvalitativa studier som handlar om tidsanvänding i förhållande till aktivitetsutförandet och aktivitetsengagemaThe thesis has provided with systematic information about how people with schizophrenia live their everyday life, and the results have shown significant relationships between occupational perspectives and health. The thesis departed in two in-depth studies that concerned time use and occupational engagement in relation to what people with schizophrenia do in their everyday life, with whom they are
