Filtyp
Ultrafast processes in matter can be captured and even controlled by using sequences of few-cycle optical pulses, which need to be well characterized, both in amplitude and phase. The same degree of control has not yet been achieved for few-cycle extreme ultraviolet pulses generated by high-order harmonic generation (HHG) in gases, with duration in the attosecond range. Here, we show that by varyi
(Neuro)psychiatric diagnoses such as attention deficit hyperactivity disorder (ADHD) is a rapidly growing and globally increasing phenomenon, not least in different educational contexts such as in family and in school. Children and youths labelled as ADHD are challenging normative claims in terms of nurturing and education, whereas those labelled as ADHD are considered a (future) risk for society (Neuro)psychiatric diagnoses such as attention deficit hyperactivity disorder (ADHD) is a rapidly growing and globally increasing phenomenon, not least in different educational contexts such as in family and in school. Children and youths labelled as ADHD are challenging normative claims in terms of nurturing and education, whereas those labelled as ADHD are considered a (future) risk for society
We have studied the fragmentation of the methanol molecule after core excitation and core ionization by observing coincidences between negative and positive ions. Five different negative ions (H-, C-, CH-, O-, and OH-) were observed at both the C 1s and O 1s edges. As negative ion formation occurs after resonant and normal Auger decay of core-hole states, it is necessarily linked with the release
It has recently been discovered that some, if not all, classical novae emit GeV gamma-rays during outburst, but the mechanisms involved in the production ofgamma-rays are still not well understood. We present here a comprehensive multiwavelength data set - from radio to X-rays - for the most gamma-ray-luminous classical nova to date, V1324 Sco. Using this data set, we show that V1324 Sco is a cano
The development of therapeutic methods based on stem cells (e.g. cell therapy, activating regeneration and organ transplantation), known as regenerative medicine, is still a novel area in the field of life sciences. If successful, such therapies could be applicable to many diseases currently lacking effective treatments, such as Parkinson’s disease, diabetes, heart disease or cancer.Stem cells are
X-ray free-electron lasers (XFELs) and table-top sources of x-rays based upon high harmonic generation (HHG) have revolutionized the field of ultrafast x-ray atomic and molecular physics, largely due to an explosive growth in capabilities in the past decade. XFELs now provide unprecedented intensity (1020 W cm-2) of x-rays at wavelengths down to ∼1 Ångstrom, and HHG provides unprecedented time res
We present a two-quantum well THz intersubband laser operating up to 192 K. The structure has been optimized using non-equilibrium Green's function model. The result of this optimization was confirmed experimentally by growing, processing, and measuring a number of proposed designs. At high temperature (T > 200 K), the simulations indicate that lasing fails due to a combination of electron-electro
OBJECTIVE: To explore the burden of gout in the Nordic region, with a population around 27 million in 2015 distributed across six countries.METHOD: We used the findings of the 2015 Global Burden of Diseases study to report prevalence and disability associated with gout in the Nordic region.RESULTS: From 1990 to 2015, the number of prevalent gout cases rose by 30% to 252 967 [95% uncertainty interv
Abstract: Proteomics has the potential to deliver disease-associated biomarkers that could provide diagnostic, prognostic and predictive information to enable precision medicine. Affinity proteomics, most commonly based on antibodies and their ability to specifically capture target proteins, has emerged has a valuable tool in biomarker discovery. Our group has developed a recombinant antibody micr
Treating neurodegenerative diseases with cell transplantation has been within reach since the first pioneering clinical trials in which dopamine neuron progenitors from the fetal brain were transplanted to individuals with Parkinson’s disease. However, the use of fetal tissue is problematic in terms of low availability and high variability, and it is also associated with ethical concerns that vary
The majority of herbivorous insects are specialized in host use. Even among insects that use many hosts, local specialization is common with a single host plant often being used in any given locality. Here, we establish such a pattern for the European swallowtail butterfly, Papilio machaon. We sampled larvae on five different natural hosts at eight sites in Sweden, each locality showing local mono
The semiarid Punata alluvial fan is located in the central part of Bolivia. The main activity of this region is the extensive agriculture, and groundwater is the main water supply. Local villagers who use groundwater reported that in some places groundwater has a salty taste. In order to investigate the origin of this problem, several TEM soundings were performed in the study area, and they were c
A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer
The design of small and high-affinity lectin inhibitors remains a major challenge because the natural ligand binding sites of lectin are often shallow and have polar character. Herein we report that derivatizing galactose with un-natural structural elements that form multiple non-natural lectin-ligand interactions (orthogonal multipolar fluorine-amide, phenyl-arginine, sulfur-π, and halogen bond)
Människans nyfikenhet och strävan att tänja på gränserna för att stilla vetgirigheten är inget nytt och kanske inte ens mest utmärkande för just vår tid. Dokumenterade källor från 1200-talet kan tjäna som goda exempel som stödjer ett sådant antagande. Mary Shelleys roman från början av 1800-talet, Frankenstein, eller moderne Prometeus, är kanske den än idag mest kända kommentaren till detta gränst
The basal ganglia are thought to be particularly sensitive to changes in dopaminergic tone, and the realization that reduced dopaminergic signaling causes pronounced motor dysfunction is the rationale behind dopamine replacement therapy in Parkinson's disease. It has, however, proven difficult to identify which neurophysiological changes that ultimately lead to motor dysfunctions. To clarify this,
