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Cardiac fibrosis, associated with a decreased extent of microvasculature and with disruption of normal myocardial structures, results from excessive deposition of extracellular matrix, which is mediated by the recruitment of fibroblasts. The source of these fibroblasts is unclear and specific anti-fibrotic therapies are not currently available. Here we show that cardiac fibrosis is associated with

I denna studie analyseras och anges metoder att beräkna värmeförlusterna mot mark. Värmeförlusterna erhålls med hjälp av formler, diagram och tabeller. Effekten av olika kantisoleringar, ändringar av ute- och innetemperaturer, köldknäppar, tjäle och snö beräknas samt värmeförluster vid ny byggnad under uppbyggnad av värmekudde.

Popular Abstract in Swedish Denna doktorsavhandling syftar till att identifiera och tolka förändringar i den marina miljön, avspeglade i Gotlands siluriska berggrund. Silurperioden (ca 444-416 miljoner år sedan) har traditionellt beskrivits som ett tidsintervall med ett varmt växthusklimat och hög global havsnivå med små miljömässiga förändringar i den marina miljön. Under det senaste decenniet haThis thesis treats the Silurian carbonate platforms of Gotland, Sweden, which formed close to the equator within the East Baltic Basin. Three different time intervals, all involving changes in facies composition and structure of the platforms, have been studied; Late Homerian, latest Homerian ? earliest Gorstian, and late Ludfordian, respectively. Two of the intervals, the Late Homerian and the la

A perceptual experiment concerning South Swedish word accents (accent I, accent II) is described. By means of editing and resynthesis techniques the F0 pattern of a test word in a phrase context has been systematically manipulated: initial rise (glide vs. jump) and final concatenation (6 timing degrees of the accentual fall). The results indicate that both a gliding rise and a late fall seem neces

The sole coat protein VP2 of infectious pancreatic necrosis virus (IPNV) was isolated and purified from intact virions, propagated in CHSE-214 cells. Likewise was the full-length VP2 protein isolated and purified upon cloning and expression of the corresponding complete gene in E. coli. The two purified proteins of different synthetic origins carrying identical primary structures were utilized in

Glucose-evoked insulin secretion exhibits two phases: The first phase represents exocytosis of insulin granules situated at the plasma membrane, whereas the second phase reflects insulin release from granules continuously recruited to the plasma membrane. This thesis investigates different aspects of phasic insulin secretion, with the specific aims to elucidate the possible contribution of insulin

Popular Abstract in Swedish Under de senaste decennierna har våra skogar utsatts för en allt högre grad av stress som en följd av förändrade produktionsmönster och en hög deposition av gödande och försurande ämnen, såsom kväve ovh svavel. Kväve är det ämne som begränsar trädens tillväxt, och det höga nedfallet av detta ämne har resulterat i att träden växt mycket snabbbare. Deras behov av andra näForests in Sweden are undergoing rapid and considerable changes regarding both management methods and environmental conditions. To understand the effects of these changes and to be able to predict impending changes in forest ecosystems, a holistic understanding of the processes governing the ecosystem is needed. To gain such an understanding, the ForSAFE model of the biogeochemical cycles in a for

This paper presents a method to calculate the forces in a chain and, thus, the resulting load distribution along the sprockets in a chain transmission working at a moderate or high speed. When the chain drive is loaded, the rollers that contact the sprockets will move along the flanks to different height positions. There are mainly two different ways to determine the actual positions: to assume th

The salvage of deoxyribonucleosides in the social amoeba Dictyostelium discoideum, which has an extremely A + T-rich genome, was investigated. All native deoxyribonucleosides were phosphorylated by D. discoideum cell extracts and we subcloned three deoxyribonucleoside kinase (dNK) encoding genes. D. discoideum thymidine kinase was similar to the human thymidine kinase 1 and was specific for thymid

The electrochemistry of the ligninolytic redox enzymes, which include lignin peroxidase, manganese peroxidase and laccase and possibly also cellobiose dehydrogenase, is reviewed and discussed in conjunction with their basic biochemical characteristics. It is shown that long-range electron transfer between these enzymes and electrodes can be established and their ability to degrade lignin through a

The aim of this study was to assess the ability of different mouse diets to sustain an H. pylori infection in BALB/cA mice. Four commercially available mouse diets were compared. Experiment 1: Mice were fed the four diets for seven days before infection, infected three times at two-day intervals with 0.1 ml of 10(9) colony-forming units/ml H. pylori cells. H. pylori strains (n = 4) were cultured o

The maximum diameter of chromite (FeCr2O4) grains within L chondrites reflects the petrographic type of the sample. On the basis of our measurements of nine recent L chondrites, L3 chromite D-mac = 34-50 mu m, L4 = 87-150 mu m, L5 = 76-158 mu m, and L6 = 253-638 mu m. This variation reflects the crystallization of the chromite grains during parent body thermal metamorphism.We use this calibration

Tredje delen i en serie om tre essäer om Paul Verhoevens amerikanska filmer.

Background. This case-control study was performed to evaluate whether adding first-trimester maternal serum testing to nuchal translucency measurement would improve the antenatal detection of Down's syndrome and decrease the number of women offered fetal karyotyping. Methods. In the Swedish Nuchal Translucency Trial 39,572 pregnant women were randomized to a routine scan at 12-14 gestational weeks