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Observational studies have revealed that ischemic heart disease (IHD) has a unique manifestation on electrocardiographic (ECG). However, the genetic relationships between IHD and ECG remain unclear. We took 12-lead ECG as phenotypes to conduct genome-wide association studies (GWAS) for 41,960 samples from UK-Biobank (UKB). By leveraging large-scale GWAS summary of ECG and IHD (downloaded from Finn

Background & AimsWhile it is recognized that non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease (CVD), how NAFLD affects the development and progression of CVD remains unclear and debatable. Hence, we aimed to determine the role of steatotic hepatocyte-derived small extracellular vesicles (sEVs) in foam cell formation and atherosclerosis progression.MethodssEVs

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a condition characterized by liver fat accumulation and metabolic abnormalities. Given the potential impact of MAFLD on patient health, it is important to understand its association with major adverse cardiovascular events (MACE) such as myocardial infarction (MI) and stroke. In the prospective UK Biobank cohort, we sought to elucidat

Road, rail, air, and sea transport generate a major fraction of outdoor ultrafine particles. However, there is no common methodology for comparable sub 100 nm particle emissions measurement. This paper presents the nPETS (grant agreement No 954377) concept to understand and mitigate the effects of emerging non-regulated nanoparticle emissions. This paper presents the concept and selected results.

Denna forskningsrapport sammanfattar resultaten från ett tvåårigt forsknings–projekt om hållbart chefskap i Helsingborgs stad. Det övergripande målet medforskningsprojektet är att bidra med kunskap om hur organisatoriskt stöd i arbetemed chefers hälsa kan och bör utformas. I denna rapport sätter vi särskilt fokus påvad cheferna själva efterfrågar för organisatoriskt stöd samt hur ett sådant stöd k

INTRODUCTION: General Movement assessment (GMA) is considered the golden standard for early identification of infants with a high risk of developing cerebral palsy (CP). The aim of this study was to explore parents' lived experience of early risk assessment for CP using a mobile application for home video recording after discharge from hospital stay in the newborn period.METHODS: An inductive qual

Background: Adults with complex congenital heart disease (CHD) show reduced aerobic exercise capacity and impaired skeletal muscle function compared with healthy peers. Peripheral muscle factors are presumed to be important contributors to the aerobic capacity, but the mechanisms are poorly understood. The aim of the present study was to investigate differences between adults with CHD and controls

Objective: The optimal timing for transplantation is unclear in patients with Eisenmenger syndrome (ES). We investigated post-transplantation survival and transplantation-specific morbidity after heart-lung transplantation (HLTx) or lung transplantation (LTx) in a cohort of Nordic patients with ES to aid decision-making for scheduling transplantation. Methods: We performed a retrospective, descrip

Firms have been increasingly relying on online user communities to access external, distant knowledge and expertise. Previous research on online user communities has largely investigated the influence of users' social capital on their knowledge sharing behavior. In this study, we propose a two-way relationship between social capital and knowledge contribution of users in online user communities. T

Forest disturbances that lead to the replacement of whole tree stands are a cornerstone of forest dynamics, with drivers that include fire, windthrow, biotic outbreaks and harvest. The frequency of disturbances may change over the next century with impacts on the age, composition and biomass of forests. However, the disturbance return time, that is, the mean interval between disturbance events, re