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Background: Preparing retrospective dose data for risk modeling using large study cohorts can be time consuming as it often requires patient-wise manual interventions. This is especially the case when considering organs at risk (OARs) not systematically delineated historically. Therefore, we aimed to develop and test a semi-automated workflow for cohort-wise preparation of radiotherapy data from t
Hematopoietic stem and progenitor cells (HSPC) from mobilized blood are the preferred graft source for allogeneic and autologous stem cell transplantation. The efficiency of CD34+ cell mobilization with granulocyte colony-stimulating factor (G-CSF) varies significantly between individuals, but is reproducible across mobilization cycles within an individual, suggesting a genetic component, a hypoth
Background: Head and neck cancer patients often experience muscle wasting due to malnutrition and the hypermetabolism of cancer. For those undergoing total laryngectomy (TL), there is the potential for peri-operative complications. Sarcopenia has gained recognition as a prognostic factor in head and neck cancer. However, there is marked variability in the ways sarcopenia is defined and poor charac
BACKGROUND: Clinical guidelines recommend different revascularization strategies for nonculprit lesions in patients with ST-segment-elevation myocardial infarction (STEMI) versus non-STEMI (NSTEMI). Whether the prevalence of untreated high-risk vulnerable plaques differs in STEMI and NSTEMI and affects their outcomes is unknown. METHODS: In PROSPECT II (Providing Regional Observations to Study Pre
OBJECTIVE AND SCOPE: A panel of clinicians, subject-matter experts, and guideline methodologists convened by the Alzheimer's Association conducted a systematic review and formulated evidence-based recommendations for using blood-based biomarkers (BBMs) in the diagnostic workup of suspected Alzheimer's disease (AD) within specialized care settings. The scope focuses on individuals with objective co
Low-energy-electron emission from resonant Auger final states via intermolecular Coulombic decay (RA-ICD) has previously been described as a promising scenario for controlling radiation damage for medical purposes, but it has so far only been observed in prototypical atomic and molecular van der Waals dimers and clusters. Here, we report the experimental observation of RA-ICD in an aqueous solutio
Context. The formation and evolution of ultra-short-period (USP) rocky planets is poorly understood. However, it is widely thought that these planets could not have formed at their present-day close-in orbits, but instead migrated inwards through interactions with outer neighbours. Aims. We aim to confirm and characterise the USP Earth-sized validated planet K2-157 b (Porb = 8.8 h) and constrain t
OBJECTIVE Chronic subdural hematoma (CSDH) is a common cause of morbidity in the older population and the incidence of CSDH is likely to increase in upcoming years due to the increasing age of the population. Surgical intervention is the cornerstone of treatment, but trials have shown conflicting results regarding the optimal type of surgical drainage. The aim of this study was to compare outcomes
PLCs are the core of most industrial automation systems (IAS). Modern IAS development emphasizes hardware unifica-tion and increased software significance. Remote PLC programming boosts efficiency by reducing time and travel costs, while supporting advanced training. Using safety controllers in the example of IAS, this paper presents hardware and PLC-specific software tools enabling remote PLC pro
Over the past 50 years, nutrient discharge into freshwater ecosystems has significantly increased due to intensive fertilizer application in China. This has led to frequent environmental issues associated with nutrient enrichment, such as algal blooms, in a number of individual lakes. However, the linkages between terrestrial nutrient sources and algal bloom occurrence (BO) at large scales remains
This study presents a cryogenic resonant radio frequency (RF) transmitter coil design for magnetic field generation that utilizes electromechanical switches to match and tune the resonance frequency with capacitor banks in situ. The design enables magnetic field generation at any frequency across a wide frequency range of 25-140 MHz (560% tuning range) while operating at 1.5 K. Magnetic field gene
Genetic trade-offs - which occur when variants that are beneficial in some contexts of natural selection are harmful in others - can influence a wide range of evolutionary phenomena, from the maintenance of genetic variation to the evolution of aging and sex differences. An extensive body of evolutionary theory has focused on the consequences of such trade-offs, and recent analyses of Fisher's geo
Clandestine migration is not only a response to precarious living conditions but also driven by aspirations and desires for change that migrants carry into their journeys. Yet, far less is known about what becomes of these subjective driving forces once people reach their destinations and settle down. To address this gap, this study explores how Syrian parents who risked crossing the Mediterranean
BACKGROUND: Differences in cardiac sarcoidosis between racial groups remain understudied. Therefore, this study aims to explore race differences in patients with cardiac sarcoidosis. METHODS: We analyzed data from the Cardiac Sarcoidosis Consortium, an international registry including over 25 centers. The primary clinical outcome was a composite end point of all-cause mortality, left ventricular a
PURPOSE. Epithelial maturation is essential for the specificity and functionality of retinal pigment epithelial (RPE) cell models. This study investigates how different maturation conditions shape RPE characteristics and cellular complement biology in two commonly used in vitro models: ARPE-19 and induced pluripotent stem cell–derived RPE (iPSC-RPE). METHODS. ARPE-19 and iPSC-RPE cells were cultur
Background: Joint pain and chronic back pain are highly prevalent in the aging population and have a large impact on life quality. As the underlying mechanisms are not fully understood, this exploratory cross-sectional study aimed to discover proteins and pathways associated with these two pain conditions in Swedish 70-year-old men. Methods: Plasma proteins (n = 720) were measured in participants
This work presents the architecture of a prototype software system for image preprocessing and analysis designed to support the guidance of an auxiliary UAV camera. The study begins with an overview of typical UAV onboard elec-tronics, highlighting the electro-optical equipment, which includes a navigation camera and an auxiliary camera with a narrower field of view. Automatic image analysis from
Formation and subsequent burial of authigenic phases have been recognized as a key process removing silicon from the ocean. However, the effect of authigenic phase formation on the isotopic mass balance of silicon in the ocean is not clear. Here, we constrain the apparent silicon isotope (δ30Si) fractionation associated with early diagenesis by measuring δ30Si signatures of pore fluids and authige
Baobab (Adansonia digitata) seeds are a source of valuable lipids with notable nutritional and functional attributes. In response to the rising demand for sustainable, high-quality oils in the cosmetic and nutraceutical sectors, there is an increasing interest in environmentally friendly extraction techniques that maintain lipid bioactivity while reducing the use of toxic solvents. This study repr
