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Superantigens from Staphylococcus aureus induce procoagulant activity and monocyte tissue factor expression in whole blood and mononuclear cells via IL-1 beta

BACKGROUND: Staphylococcus aureus is one of the most common bacteria in human sepsis, a condition in which the activation of blood coagulation plays a critical pathophysiological role. During severe sepsis and septic shock microthrombi and multiorgan dysfunction are observed as a result of bacterial interference with the host defense and coagulation systems.OBJECTIVES: In the present study, staphy

Immunsvar och inflammation vid Crohns sjukdom. Snart möjligt driva diagnostiken längre och utveckla mer specifika läkemedel

The chronic inflammation in Crohn's disease may be caused by aggressive response to bacterial antigens normal to the gut. Genetic and environmental factors modify the inflammatory response evoked by damage to the mucosal gut barrier. Genetic factors may also determine the subsequent course of chronic inflammation. Further elucidation of the pathogenesis might improve our understanding of the heter

Computational Studies of Molybdenum and Tungsten Enzymes

We review computational studies of three important mono-nuclear molybdenum oxo-transfer enzymes, dimethylsulfoxide reductase, sulfite oxidase and xanthine oxidase. We show that calculated energies for these reactions are very sensitive to details in the calculations, in particular to the density-functional method employed and the size of the basis set, but the treatment of dispersion and solvation

Law, Community and the 2011 London Riots

Can local communities on the margins of society be charged with the responsibility of maintaining their own social order? What type of law (if any) can bring social order to these communities? Using semi-structured interviews with social workers, police officers, lawyers and other professionals familiar with the Tottenham riots, this chapter offers an inside view into what community means in a runCan local communities on the margins of society be charged with the responsibility of maintaining their own social order? What type of law (if any) can bring social order to these communities? Using semi-structured interviews with social workers, police officers, lawyers and other professionals familiar with the Tottenham riots, this chapter offers an inside view into what community means in a run