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The interaction between our immune system and pathogens encompasses a complex spectrum from symbiosis to potentially life-threatening diseases. Throughout evolution, our immune system has evolved numerous strategies such as phagocytosis to combat infections and protect us from diseases. Phagocytosis involves the engulfment of pathogens by our immune cells and can be facilitated through opsonizatio

Filaggrin (FLG), a skin barrier protein, is associated with higher dermal uptake of some chemicals in carriers of loss-of-function (null) mutations. This study investigates FLG mutations and systemic effects following dermal exposure to chemicals. Individuals (n = 23 FLG null, n = 31 FLG wt) were simultaneously exposed to pyrimethanil, pyrene, oxybenzone, and nickel ions for 4 h. Pre- and post-exp

The Storage Location Assignment Problem (SLAP) has a significant impact on the efficiency of warehouse operations. We propose a multi-phase optimizer for the SLAP, where the quality of an assignment is based on distance estimates of future-forecasted order-picking. Candidate assignments are first sampled using a Markov Chain accept/reject method. Order-picking Traveling Salesman Problems (TSPs) ar

ObjectivesPre-treatment staging of anal squamous cell carcinoma (ASCC) includes pelvic MRI and [18F]-fluorodeoxyglucose positron emission tomography with computed tomography (PET-CT). MRI criteria to define lymph node metastases (LNMs) in ASCC are currently lacking. The aim of this study was to describe the morphological characteristics of lymph nodes (LNs) on MRI in ASCC patients with PET-CT-posi

Background Heart failure (HF) commonly arises as a complication to cardiovascular diseases and is closely associated with various comorbidities. The impacts of these comorbidities in patients with HF are diverse. We aimed to analyze the increased risk for cardiovascular-related readmission within 100 days after discharge in patients with HF depending on their different comorbidities. Methods A pop

Background: Outliers can influence regression model parameters and change the direction of the estimated effect, over-estimating or under-estimating the strength of the association between a response variable and an exposure of interest. Identifying visit-level outliers from longitudinal data with continuous time-dependent covariates is important when the distribution of such variable is highly sk

Under medeltiden, men även under århundradena närmast efter, var läkekonsten och vården av sjuka ett brokigt kunskapsfält med flera olika traditioner, medicinska kulturer och praktiker. Sedan medeltiden hade kristenheten dryftat och stridit om vilket ansvar människan har för sin kropp i förhållande till Guds allmakt över liv och död, om smärtans ok visavi lidandet som möjlighet till religiös botgö

Anonymisation of assessments has been discussed for decades. It stems from a concern about unduly bias in assessment and grading. In Sweden, anonymised assessments were introduced in many universities a decade ago. It was rarely preceded by discussions on potential pedagogical consequences. Recent research on the effects of anonymisation does not confirm the hypothesis of reduced bias in grading.

Importance: International guidelines recommend body temperature control below 37.8 °C in unconscious patients with out-of-hospital cardiac arrest (OHCA); however, a target temperature of 33 °C might lead to better outcomes when the initial rhythm is nonshockable. Objective: To assess whether hypothermia at 33 °C increases survival and improves function when compared with controlled normothermia in

Background. Poor maternal self-rated health in healthy women is associated with adverse neonatal outcomes, but knowledge about self-rated health in pregnant women with congenital heart disease (CHD) is sparse. This study, therefore, investigated self-rated health before, during, and after pregnancy in women with CHD and factors associated with poor self-rated health. Methods. The Swedish national

This chapter explores collaboration between Sweden’s Art and Music Schools (SAMS) and compulsory schools from the perspectives of leaders in SAMS, highlighting their policy practices. Furthermore, it offers insights into the ways music education leaders can and do engage in policy practice adaptation and how policy practice draws from contextual needs and strengths while at the same time respondin

Aims: This study examined whether women in Sweden who had been in an intimate partner violence (IPV) relationship reached post-traumatic growth (PTG) and if the level of PTG differed for women who had received formal help compared with women who had not received formal help. The study also examined whether there was a difference in the level of PTG depending on which type of formal help the women

För- och nackdelar med anonymisering av examinationer har diskuterats i decennier. Det är inte svårt att förstå varför ämnet har varit brännande och att det varit så under lång tid. Frågan har i hög grad varit studentdriven, både i Sverige och internationellt, och har sin grund i oro för bias vid bedömning och betygsättning. I Sverige infördes anonymisering av examinationer vid många lärosäten förAdvantages and disadvantages of anonymisation of assessment procedures have been discussed for decades. It is not difficult to understand why the issue has been on the agenda for such a long time. To a large extent, both in Sweden and internationally, it is the students who request anonymisation in examination procedures, and their demands stem from a concern about bias in assessment and grading.