A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts

Systemic lupus erythematosus (SLE) is an autoimmune disorder with heterogeneous clinical presentation and complex etiology involving the interplay between genetic, epigenetic, environmental and hormonal factors. Many common SNPs identified by genome wide-association studies (GWAS) explain only a small part of the disease heritability suggesting the contribution from rare genetic variants, undetect

Prisoner resettlement in Sweden

In Sweden most prisoners serve a short prison sentence. Since the majority of all prisoners are subject to mandatory pre-release after having served two-thirds of the sentence, few spend more than four months in prison. Still, there is a group who serve prison sentences of two years or more. The resettlement process varies for the two groups, but all prisoners have a right to be supported, aiming

RIFM fragrance ingredient safety assessment, linalyl phenylacetate, CAS Registry Number 7143-69-3

RIFM fragrance ingredient safety assessment, 10-undecenoic acid, heptyl ester, CAS Registry Number 68141-27-5

RIFM fragrance ingredient safety assessment, pentyl phenylacetate, CAS Registry Number 5137-52-0

RIFM fragrance ingredient safety assessment, methyl isobutyrate, CAS Registry Number 547-63-7

RIFM fragrance ingredient safety assessment, isononyl acetate (isomer unspecified), CAS Registry Number 40379-24-6

RIFM fragrance ingredient safety assessment, citronellyl phenylacetate, CAS Registry Number 139-70-8

RIFM fragrance ingredient safety assessment, ethyl trans-2-butenoate, CAS Registry Number 623-70-1

RIFM fragrance ingredient safety assessment, ethyl 2-methylbutyrate, CAS Registry Number 7452-79-1

RIFM fragrance ingredient safety assessment, 2-methylbutyl butyrate, CAS Registry Number 51115-64-1

RIFM fragrance ingredient safety assessment, methyl isovalerate, CAS Registry Number 556-24-1

RIFM fragrance ingredient safety assessment, butyl benzoate, CAS registry number 136-60-7

RIFM fragrance ingredient safety assessment, octahydro-4,7-methano-1H-indenemethyl formate, CAS Registry Number 68039-78-1

Future Liver Remnant (FLR) Increase in Patients with Colorectal Liver Metastases Is Highest the First Week After Portal Vein Occlusion : FLR Increase in Patients with CRLM Is Highest the First Week After PVO

Background: Portal vein occlusion (PVO) is an established method to increase the volume of the future liver remnant (FLR). The main reasons for not proceeding to radical hepatectomy are lack of volume increase and tumor progression due to a wait-time interval of up to 8 weeks. The hypothesis was that the increase in FLR volume is not linear and is largest during the first weeks. Methods: Patients

Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis

Background: Aortic valve stenosis (AVS) and coronary artery disease (CAD) have a significant genetic contribution and commonly co-exist. To compare and contrast genetic determinants of the two diseases, we investigated associations of the LPA and 9p21 loci, i.e. the two strongest CAD risk loci, with risk of AVS. Methods: We genotyped the CAD-associated variants at the LPA (rs10455872) and 9p21 loc

Collective memory and competition over identity in a conflict zone: the case of Dersim.

Book review: Formation of the Turkish Nation‐State, 1920–1938

Broad threat to humanity from cumulative climate hazards intensified by greenhouse gas emissions

The ongoing emission of greenhouse gases (GHGs) is triggering changes in many climate hazards that can impact humanity. We found traceable evidence for 467 pathways by which human health, water, food, economy, infrastructure and security have been recently impacted by climate hazards such as warming, heatwaves, precipitation, drought, floods, fires, storms, sea-level rise and changes in natural la

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