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BackgroundSelection of systemic therapy for primary breast cancer is currently based on clinical biomarkers along with stage. Novel genomic tests are continuously being introduced as more precise tools for guidance of therapy, although they are often developed for specific patient subgroups. The Sweden Cancerome Analysis Network – Breast (SCAN-B) initiative aims to include all patients with breast

Background: Coffee drinking has been implicated in mortality and a variety of diseases but potential mechanisms underlying these associations are unclear. Large-scale systems epidemiological approaches may offer novel insights to mechanisms underlying associations of coffee with health. Objective: We performed an analysis of known and novel protein markers linked to cardiovascular disease and thei

In 2010, the first, and so far only, infestation of the Hungarian spruce scale (Physokermes inopinatus) and accompanying sooty mould occurred in Scania, southernmost Sweden. About 1000 ha of Norway spruce (Picea abies) were affected, and the trees suffered from the sucking of the insects as well as from the dense sooty mould that covered the needles. Salvage cuttings were carried out in many of th

Analyses of foraminiferal assemblages have often been implemented on dry samples, which are easy to split. In some cases, the wet-picking method is preferred as it allows the preservation of more foraminiferal forms and facilitates the picking of live foraminifera. However, the increased execution time needed for wet picking may cause micropalaeontologists to refrain from employing it in a routine

PURPOSE: In order to study pain in children, it is necessary to determine whether pain measurement tools used in adults are reliable measurements in children. The aim of this study was to explore the intrasession reliability of pressure pain thresholds (PPT) in healthy children. Furthermore, the aim was also to study the intersession reliability of the following four tests: (1) Total Tenderness Sc

Chemistry and Human Health, Division VII of the International Union on Pure and Applied Chemistry (IUPAC), provides guidance on risk assessment methodology and, as appropriate, assessment of risks to human health from chemicals of exceptional toxicity. The aim of this document is to describe dose-response relationships for the health effects of low-level exposure to cadmium, in particular, with an

This paper deals with the numerical investigation of ellipticity of the boundary value problem for isothermal finite strain elasto-plasticity. Ellipticity can be lost when softening occurs. A discontinuity surface then appears in the considered material body and this is associated with the ill-posedness of the boundary value problem. In the paper the condition for ellipticity loss is derived using

Established approaches to data aggregation in wirelesssensor networks (WSNs) do not cover the variety of new usecases developing with the advent of the Internet of Things. In particular,the current push towards fog computing, in which control,computation, and storage are moved to nodes close to the networkedge, induces a need to collect data at multiple sinks, ratherthan the single sink typically

This paper provides an empirical analysis of the effectiveness of real-time feedback technology in the Swedish residential sector. We take the ‘100Koll’ service provided by one the largest energy companies in Sweden as a case study. Based on an intervention group (i.e. people using the service) of 1 753 households, a survey was carried out to explore behavioural, moral, socio-economic and contextu

Objectives: to evaluate the frequency of potentially inappropriate medication (PIM) prescription among older people with dementia (PwD) from eight countries participating in the European study 'RightTimePlaceCare', and to evaluate factors and adverse outcomes associated with PIM prescription.Methods: survey of 2,004 PwD including a baseline assessment and follow-up after 3 months. Interviewers gat

Chondroitin sulfate (CS)/dermatan sulfate (DS) proteoglycans are abundant on the cell surface and in the extracellular matrix and have important functions in matrix structure, cell-matrix interaction and signaling. The DS epimerases 1 and 2, encoded by Dse and Dsel, respectively, convert CS to a CS/DS hybrid chain, which is structurally and conformationally richer than CS, favouring interaction wi

The aim of this work was to compare the production of carotenes and ergosterol by red yeasts grown on pine lignocellulose substrates. The yeast strains Rhodotorula aurantiaca and Sporobolomyces shibatanus were grown on the liquid fraction of steam pretreated pine (210 °C, catalyst SO2). Biomass production on a pine hydrolysate was lower than on glucose. The highest content of carotenoids and ergos

Cellular homeostasis requires precise communication between various types of organelles. In particular, the communication between nucleus and semiautonomous organelles, mitochondria and chloroplasts, has received widespread attention. Communication from nucleus to other organelles is known as anterograde signaling, whereas communication from mitochondria or chloroplasts to the nucleus is known as

Conjugated polymers have been widely studied as flexible, versatile semiconductors in organic electronics. However, the material stability is one of the problems limiting their applications. Thus, understanding the degradation process of conjugated polymers is crucial. In this work, we monitored the chain scission of the model polymer MEH-PPV in chloroform solutions under different conditions by a

Combined U-Pb, O and Lu-Hf isotope analyses of detrital zircon grains from five major rivers in Ghana are used to investigate the growth and evolution of the Birimian terrane of the West African Craton. The majority of the analysed zircon yields supra-chondritic εHf values, suggesting derivation from primarily juvenile host magmas. Zircon grains from the Birim River in southwestern Ghana deviate f

Due to the high surface area to volume ratios leading to intensified heat and mass transfer rates, microreactors have been subject of interest for some time. Liquid-liquid two-phase flow is a very common phenomenon in microchannels. During the scale-up using a numbering-up approach, rectangular and square microchannels are preferred to circular microchannels in terms of easier integration of the f

Drawing from extensive fieldwork among graffiti writers in Sweden this article investigates gendered identity work and its consequences. It points to how potentially inclusive aspects of disembodied subcultural Performances-that identities are negotiated through the material representation of the writer rather than on basis of the physical body-nevertheless work exclu-dingly, especially so in term

Measurement of endwall heat transfer around a circular cylinder with a vortex generator pair has been investigated. Steady state liquid crystal thermography is adopted. Cylinders having two different height to diameter ratios have been employed. In one case, the cylinder has one end free in the flow and in the other case it has both ends attached on the walls. Local Nusselt numbers both upstream a

Previous research has proved Double-layer Microchannel Heat Sinks (MHSs) to be efficient ways to improve the cooling performance of electronic devices. However, the cooling potential of the upper working liquid cannot be fully utilized to cool down the substrate with the heated elements. In this sense, a concept of staggered double-layer MHS is proposed and designed. The parallel and counter flow

In most industrial product development projects, computer-based design analysis, or simply design analysis, is frequently utilized. Several design analysis process models exist in the literature for the planning, execution and follow-up of such design analysis tasks. Most of these process models deal explicitly with design analysis tasks within two specific contexts: the context of design evaluati