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Remote homology detection among proteins utilizing only the unlabelled sequences is a central problem in comparative genomics. The existing cluster kernel methods based on neighborhoods and profiles and the Markov clustering algorithms are currently the most popular methods for protein family recognition. The deviation from random walks with inflation or dependency on hard threshold in similarity

In this paper we propose an automatic protein family expansion approach for recruitment of new members among the protein-coding genes in newly sequenced genomes. The criteria for adding a new member to a family depends on the structure of each individual family versus being globally uniform. The detection of a threshold in the ROC space of all sorted iterative profile sets defines the alignments s

Polyploidization is an important process in the evolution of eukaryotic genomes, but ensuing molecular mechanisms remain to be clarified. Autopolyploidization or whole-genome duplication events frequently are resolved in resulting lineages by the loss of single genes from most duplicated pairs, causing transient gene dosage imbalance and accelerating speciation through meiotic infertility. Allopol

We will discuss the evolution of star clusters with a large initial binary fraction, up to 95%. The initial binary population is chosen to follow the invariant orbital-parameter distributions suggested by Kroupa (1995). The Monte Carlo MOCCA simulations of star cluster evolution are compared to the observations of Milone et al. (2012) for photometric binaries. It is demonstrated that the observed

The human pathogen Enterococcus faecalis can degrade the N-linked glycans of human RNase B to acquire nutrients, but no gene or protein has been associated with this activity. We identified an 88-kDa secreted protein, endoglycosidase (Endo) E, which is most likely responsible for this activity. EndoE, encoded by ndoE, consists of an α-domain with a family 18 glycosyl hydrolase motif and a β-domain

Immunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections. Therefore, it is not very surprising that bacterial pathogens and commensals through co-evolution with their hosts have learned many tricks to interfere with Fc effector functions. In this chapter, we describe thre

Staphylococcus aureus is the causative agent of several serious infectious diseases. The emergence of antibiotic-resistant S. aureus strains has resulted in significant treatment difficulties, intensifying the need for new antimicrobial agents. Toward this end, we have developed a novel chimeric bacteriophage (phage) lysin that is active against staphylococci, including methicillin-resistant S. au

För att bättre kunna förebygga att skelettet bryts ner vid långvarig vila eller vid sjukdomarsom osteopenia och osteoporos, behövs bättre förståelse för de processer somstyr detta. I den här avhandlingen antas att den primära orsaken till bentillväxt är enförändring i den kemiska miljön i benet. Förändringen antas orsakas av att tillväxtstimulerandeämnen transporteras genom benet till den plats däIn order to prevent or modify bone degeneration due to rest or due to diseases such as osteopenia and osteoporosis, the modeling and remodeling of bone tissue must be better understood. In this thesis it is assumed that the primary condition leading to bone growth is a change of the chemical environment caused by transport of matter resulting from stress driven diffusion. The change in the chemica

Forskare vid Lunds universitet har upptäckt ett cellskelett som ger struktur åt mito-kondrierna, cellens energifabriker. Skelettet är nödvändigt för mitokondriernas funktion, men forskarna fann även att cancerceller trots defekter utnyttjar skelettet för att kunna bibehålla sin energiproduktion – och därigenom överleva. Cellskelettet i mitokondrierna fungerar ungefär som ett armeringsnät och hjälp

The word skeleton sounds very significant, and indeed humans could not exist without a skeleton! Similarly, a cellular skeleton or cytoskeleton is crucial for the functions of a cell. Several different types of cytoskeleton have been identified that are necessary, for among other things, muscle movement and the activities of the brain, and consequently humans could not function at all without cytosk

Sessions included an overview of past cell therapy (CT) conferences sponsored by the International Alliance for Biological Standardization (IABS). The sessions highlighted challenges in the field of human pluripotent stem cells (hPSCs) and also addressed specific points on manufacturing, bioanalytics and comparability, tumorigenicity testing, storage, and shipping. Panel discussions complemented t

Ordet κλώταξ är känt från en enda bevarad antik grekisk text, Kosmas Indikopleustes’ Topographia Christiana, där det förekommer sammanlagt fyra gånger. Översättare och lexikografer har haft besvär med ordet. Detta är ett försök att närmare precisera dess betydelse samt att göra det troligt att κλώταξ är synonymt med det något vanligare κνώδαξ.

Background: The genetic architecture of birth size may differ geographically and over time. We examined differences in the genetic and environmental contributions to birthweight, length and ponderal index (PI) across geographical-cultural regions (Europe, North America and Australia, and East Asia) and across birth cohorts, and how gestational age modifies these effects. Methods: Data from 26 twin

In the last decades, nanotechnology has played a key role in the electrochemical biosensor development based on the mediated and direct electrochemical communication between the biorecognition elements and the electrode surface. In particular, graphene and 2D-like nanomaterials (e.g., boron nitride nanosheets, graphitic carbon nitride (g-C3N4) nanosheets, and various transition metal dichalcogenid

The level structure of Nd136 has been investigated using the Mo100(Ar40,4n) reaction and the JUROGAM II+RITU+GREAT setup. The level scheme has been extended significantly. Many new bands have been identified both at low and high spin, among which are five nearly degenerate bands interpreted as chiral partners. Excitation energies, spins, and parities of the previously known bands are revised and f

OBJECTIVE: Changes in ECG-derived parameters are studied in atrial fibrillation (AF) patients undergoing cryoballoon catheter ablation.APPROACH: Parameters characterizing f-wave frequency, morphology by phase dispersion, and amplitude are estimated using a model-based statistical approach. These parameters are studied before, during, and after ablation, as well as for AF type (paroxysmal/persisten

INTRODUCTION: Hip and knee osteoarthritis is a leading cause of disability worldwide. Currently, the course of deterioration in pain and physical functioning in individuals with osteoarthritis is difficult to predict. Factors such as socioeconomic status and comorbidity contribute to progression of osteoarthritis, but clear associations have not been established. There is a need for early identifi

OUTCOMES: MHCT included number of contacts with: general practitioner (GP), GP mental health counselling, psychologist, psychiatrist, emergency contacts, admissions to psychiatric hospitals and prescriptions of antidepressants.OBJECTIVE: Examine whether the severity of symptoms of depression was associated with the type of mental healthcare treatment (MHCT) received, independent of socioeconomic p