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Androgen deprivation therapy (ADT) is frequently used for the treatment of advanced prostate cancer. ADT is associated with numerous side effects related to its mode of action, namely the suppression of testosterone to castrate levels. Recently, several large retrospective studies have also reported an increased risk of diabetes and cardiovascular disease in men receiving ADT, although these risks
We used isotension-ensemble Monte Carlo simulations to study the properties of brush layers of bottle-brush polymers under lateral compression. The polymers were represented by a freely jointed hard-bead model with one side chain grafted to each bead of the main chain, and we considered variations in side-chain length and bead size. Brush properties, including brush height and surface pressure, we
Background Compared with placebo, prophylactic treatment with bisphosphonates reduces risk of skeletal events in patients with multiple myeloma. However, because of toxicity associated with long-term bisphosphonate treatment, establishing the lowest effective dose is important. This study compared the effect of two doses of pamidronate on health-related quality of life and skeletal morbidity in pa
Non-invasive diode laser spectroscopy was, for the first time, used to assess gas content in the intestines and the lungs of a new-born, 4 kg, baby. Two gases, water vapor and oxygen, were studied with two low-power tunable diode lasers, illuminating the surface skin tissue and detecting the diffusely emerging light a few centimeters away. The light, having penetrated into the tissue, had experien
With fast growing power consumption and device miniaturization, micro/minichannels are superior to macrochannels or conventional channels for high heat-flux dissipation due to their large surface area to volume ratios and high heat transfer coefficients. However, the associated large pressure drop penalty and flow boiling instability of micro/minichannels hinder their advancement in many practical
Time-resolved spectroscopy has an emerging role among modern material-characterization techniques. Two powerful theoretical formalisms for systems out of equilibrium (and thus for time-resolved spectroscopy) are Non-Equilibrium Green’s Functions (NEGF) and Time-Dependent Density Functional Theory (TDDFT). In this chapter, we offer a perspective (with more emphasis on the NEGF) on their current cap
A simulation study of daylight autonomy in perimeter office rooms at high latitudes is presented where the following variables are studied: Glazing-to-wall ratios (GWR), climate, orientation, inner surface reflectance, glazing visual transmittance, Venetian blind management and electric lighting dimming and switching systems. Based on daylight utilisation alone, the results indicate an optimal GWR
Live surgery is an important part of surgical education, with an increase in the number of live surgery events (LSEs) at meetings despite controversy about their real educational value, risks to patient safety, and conflicts of interest.
Abstract in UndeterminedObjective: This study examined the effects of chronic focal lesions to the lateral prefrontal cortex (LPFC) or orbitofrontal cortex (OFC) on neuropsychological test performance and self-reported executive functioning in everyday living. Methods: Fourteen adults with OFC lesions were compared to 10 patients with LPFC injuries and 21 healthy controls. Neuropsychological tests
Objective:To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in five to nine-year-old children.Methods:Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pair
Photoexcitation of conjugated polymerfullerene blends results in population of a local charge transfer (CT) state at the interface between the two materials. The competition between recombination and dissociation of this interfacial state limits the generation of fully separated free charges. Therefore, a detailed understanding of the CT states is critical for building a comprehensive picture of t
Whether orthostatic hypotension (OH) is a risk factor for cardiovascular morbidity and death is uncertain. Currently available evidence derives from non-homogeneous and partly ambiguous studies.
The changes in the microstructure of tomato paste suspensions have been investigated during homogenisation and subsequent shearing in suspensions with similar composition, at three tomato paste concentrations 10, 30 and 40%. The suspensions were characterised by the particle size distribution (PSD), volume fraction (empty set), and dynamic theological properties (G`, G ''). All suspensions exhibit
The enzymatic conversion of mixtures of multiple substrates was studied quantitatively, based on established methodology used for the enzymatic kinetic resolution of racemic mixtures, involving the use of competitive factors: ratios of specificity constants (k(cat) /K(M) ) of substrate pairs. The competitive factors of the substrates were defined in relation to a reference substrate. These competi
The current European policy agenda strongly accentuates the importance of research and development (R&D) as a driver of economic growth. The basic assumption is that high European wage levels make it unlikely that less research-intensive parts of the economy can withstand competition from low-wage countries with increasingly skilled labour forces. Thus, the inferior growth of the European Unio
Our aim was to identify the best diagnostic test sequence for predicting Alzheimer's disease (AD)-type dementia in subjects with mild cognitive impairment (MCI) using cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) biomarkers. We selected 153 subjects with mild cognitive impairment from a multicenter memory clinic-based cohort. We tested the CSF beta amyloid (A beta)1-42/tau ratio u
This article analyzes neoliberal articulations of the economic crisis in Greece, as they appear at the Ekathimerini daily. Neoliberalism is primarily understood as the ideology organizing the political strategies of late capitalist production. The analysis focuses on the ways the capitalist crisis is presented in the context of Greece, as well as the ways that socio-political opposition to neolibe
A methodology for local stakeholders' involvement in water management using a catchment model as a platform for dialogue has been developed and tested in the Kaggebo Bay drainage area in the southeast of Sweden. The process involved farmers, rural households not connected to municipal wastewater treatment facilities, local and regional authorities as well as different water and agricultural expert
