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The presence of amyloid plaques composed of amyloid beta (A beta) fibrils is a hallmark of Alzheimer's disease (AD). The A beta peptide is present as several length variants with two common alloforms consisting of 40 and 42 amino acids, denoted A beta(1-40) and A beta(1-42), respectively. While there have been numerous reports that structurally characterize fibrils of A beta(1-40), very little is

As a part of the LDTA 2011 Tool Challenge, we implemented a compiler for the language Oberon-0 using the metacompilation tool JastAdd. In this paper, we report on this implementation, and reflect on aspects of it such as ease of use, modularity, and safety.

We have studied the formation of a Bi-induced (2 x 2) reconstruction on the InAs(111)B surface. In connection to the development of the (2 x 2) reconstruction, a two dimensional charge accumulation layer located at the bottom of the InAs conduction band appears as seen through a photoemission structure at the Fermi level. Not well ordered Bi layers do not induce a charge accumulation. The Bi-induc

Cell-cycle progression is a one-way journey where the cell grows in size to be able to divide into two equally sized daughter cells. The cell cycle is divided into distinct consecutive phases defined as G(1) (first gap), S (synthesis), G(2) (second gap) and M (mitosis). A non-proliferating cell, which has retained the ability to enter the cell cycle when it receives appropriate signals, is in G(0)

The aim of this project was to generate knowledge to enable us to take advantage of heat storage in heavy building structures with regard to as energy savings, better thermal indoor climate, and reduced peak powers. This could include buildings that can function without energy input during cold periods, buildings that give a robust indoor climate without installed cooling, and buildings with good

An important criterion for the selection of a probiotic bacterial strain is its ability to adhere to the mucosal surface. Adhesion is usually mediated by proteins or other components located on the outer cell surface of the bacterium. In the present study we characterized the adhesive properties of two classical intracellular enzymes glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and enolase (EN

To test the hypothesis that dissolved organic nitrogen (DON) is important for sustaining primary production by the microphytobenthos (MPB) in nitrogen-limited conditions, we measured the uptake of (15)N-labelled urea, the amino acids glycine (GLY) and glutamic acid (GLU), and nitrate and ammonium under simulated in situ light and temperature conditions. Microphytobenthic primary production and chl

The issue of indirect land use changes (ILUC) caused by the promotion of transport biofuels has attracted considerable attention in recent years. In this paper, we reviewed the current literature on modelling work to estimate emissions of greenhouse gases (GHG) caused by ILUC of biofuels. We also reviewed the development of ILUC policies in the EU. Our review of past modelling work revealed that m

We explore how two community-based reform models align with the World Bank's World Development Report 2004 accountability framework. Using a qualitative case study of rural Guatemalan primary schools, we examine local governance through interviews with a range of stakeholders. While both reforms appear appropriate according to the World Bank's accountability framework, especially the model giving

Amyloid deposits from several human diseases have been found to contain membrane lipids. Co-aggregation of lipids and amyloid proteins in amyloid aggregates, and the related extraction of lipids from cellular membranes, can influence structure and function in both the membrane and the formed amyloid deposit. Co-aggregation can therefore have important implications for the pathological consequences

This work investigates the way humans plan their paths in a goal-directed motion, assuming that a person acts as an optimal controller that plans the path minimizing a certain (unknown) cost function. Taking this viewpoint, the problem can be formulated as an inverse optimal control one, i.e., starting from control and state trajectories one wants to figure out the cost function used by a person w

This dissertation explores intervention practices for children and young persons with developmental disabilities. It focuses especially health and medically related services provided by the local children habilitation centres (CHC: s), where everyday services are carried out by interprofessional teams of habilitation specialists.The objective was to critically examine the CHC as a human service or

OBJECTIVE: The aim of the study was to examine the double locked-in phenomenon at work (i.e., being in a non-preferred occupation and non-preferred work place), and its associations to psychological health, physical health and job satisfaction. METHODS: A total of 136 municipal employees who visited a career coaching center (response rate 59%) participated in the questionnaire study. RESULTS: The

In this paper we look at opportunities to support the creation of value for all through the use of end-user-owned Virtual Personal Assistant. We use a chat-bot as example of technology with a possibility for transferring and diffusing new functionality, features and capabilities. This category of software can create potential value through its AI and natural language processing combined with emula

We report on the synthesis of non-tapered wurtzite (WZ) GaP nanowires by use of in-situ etching and the structural and optical characterization thereof. HCl was evaluated as an in-situ etchant in order to impede the onset of radial growth since the WZ crystal phase in GaP nanowires preferentially grows at relatively high growth temperatures around 600 degrees C, at which strong radial growth typic

Background Alpha-1-antitrypsin (A1AT) deficiency is the only recognised genetic risk factor for chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality worldwide. Since A1AT is the major inhibitor of neutrophil elastase (NE), this enzyme has become widely implicated in the pathogenesis of COPD in general; however, there is currently no specific biomarker for its pr