Aplastic anemia is a rare life-threatening disease. However, since the introduction of immunosuppressive therapy and allogeneic stem cell transplantation, the outcome has improved considerably, and the 5-year survival is reported to be 70–80% in selected patient cohorts. Yet, contemporary population-based data on incidence and survival are lacking. We performed a national retrospective study to de

Background: Many existing patient-reported outcome measures are extensive regarding both patient burden and administration, and in terms of analysing and reporting results. The VascuQoL-6 (VQ6) - a short version of the original Vascular Quality of Life Questionnaire (VascuQoL), a disease-specific instrument for peripheral arterial disease - was recently developed. However, the VQ6 has not yet been

This paper discusses the application of university extension practice in the establishment of new tourism enterprises, with a particular focus on culinary tourism enterprises. The discussion is framed by the ‘missions’ perspective of university function, noting that extension is a form of knowledge transfer falling within the ‘Third Mission’ of universities. A case study approach is used to show h

A central issue in the study of primate communication is the extent to which individuals adjust their behaviour to the attention and signals of others, and manipulate others’ attention to communicate about external events. I investigated whether 13 chimpanzees (Pan troglodytes spp.), 11 bonobos (Pan paniscus), and 7 orangutans (Pongo pygmaeus pygmaeus) followed conspecific attention and led others

Background: Intimate partner violence against women (IPVAW) is a global and preventable public health problem. Public attitudes, such as victim-blaming, are important for our understanding of differences in the occurrence of IPVAW, as they contribute to its justification. In this paper, we focus on victim-blaming attitudes regarding IPVAW within the EU and we apply multilevel analyses to identify

Background: Human fibroblasts can be directly converted to several subtypes of neurons, but cortical projection neurons have not been generated. Methods: Here we screened for transcription factor combinations that could potentially convert human fibroblasts to functional excitatory cortical neurons. The induced cortical (iCtx) cells were analyzed for cortical neuronal identity using immunocytochem

Background: Rett syndrome (RTT) is a rare neurodevelopmental disorder leading to multiple disabilities and high dependency on caregivers. This study aimed to: (1) describe the patterns of sedentary time and daily steps and (2) identify the association of individual and environmental characteristics with sedentary time. Methods: All Danish females with RTT older than 5 years of age and with a MECP2

Chemical hypersensitivity reactions induced in the skin or in the respiratory tract are important health concerns and develops following repeated exposure to certain chemicals, termed sensitizers. To prevent such hazardous compounds from entering the consumer market, legal frameworks within EU require chemicals to be tested for their capacity to induce hypersensitivity. This type of testing has trChemical hypersensitivity reactions induced in the skin or in the respiratory tract are important health concerns and develops following repeated exposure to certain chemicals, termed sensitizers. To prevent such hazardous compounds from entering the consumer market, legal frameworks within EU require chemicals to be tested for their capacity to induce hypersensitivity. This type of testing has tr

This thesis was designed to investigate health-related quality of life, functional level and needs of care the first year after dysvascular major lower limb amputation and consists of four studies with three different designs. A grounded theory was constructed in Study I. Data collection was guided by theoretical sampling and comprised of observations and interviews with eleven patients.The substa

This edited collection explores the background and implementation of the Nordic Barnahus (or 'Children's House') model - recognised as one of the most important reforms related to children who are the victims of crime in the Nordic region. This book discusses both its potential to affect change and the challenges facing it. The model was introduced as a response to a growing recognition of the neeThis edited collection explores the background and implementation of the Nordic Barnahus (or 'Children's House') model - recognised as one of the most important reforms related to children who are the victims of crime in the Nordic region. This book discusses both its potential to affect change and the challenges facing it. The model was introduced as a response to a growing recognition of the nee

Rheumatoid Arthritis (RA) is a chronic, inflammatory, and systemic disease of unknown aetiology that affects0.5‒1.0% of the population in Europe, more women than men. Pain, physical disability, fatigue, and sleepdisturbances are some of the most pronounced symptoms in patients with a more severe disease or with a longerdisease duration, resulting in activity limitations that affect quality of lifeRheumatoid Arthritis (RA) is a chronic, inflammatory, and systemic disease of unknown aetiology that affects 0.5‒1.0% of the population in Europe, more women than men. Pain, physical disability, fatigue, and sleep disturbances are some of the most pronounced symptoms in patients with a more severe disease or with a longer disease duration, resulting in activity limitations that affect quality of l

The paper presents results from a comparative study of selected biological and technical functions for thermal adaptability, which are based on an extensive literature review in biology and façade engineering. Several selected biological role models have been analysed in detail to identify their principles for dealing with thermal adaptation. These principles have been further abstracted through s

Sample quality is of major importance when conducting molecular analysis of nucleic acids, and factors such as degradation, presence of impurities, and enzymatic inhibitors may have a significant impact on the quality of data. Issues of quality assessment become more important as the increased use of biobanking means that whole blood samples are being stored for longer periods. A range of commerci

BCL11A is a major regulator of fetal hemoglobin production. Reduced levels of BCL11A have been shown to delay switching from fetal to adult hemoglobin, suggesting that it acts as a stage-specific repressor of gamma globin expression. We have carried out a survey of BCL11A binding in the globin, BCL11A and GATA1 loci by ChIP-on-chip analysis in primary human erythroid cells. We found strong occupan

Individual variation in fetal hemoglobin (HbF, alpha(2)gamma(2)) response underlies the remarkable diversity in phenotypic severity of sickle cell disease and beta thalassemia. HbF levels and HbF-associated quantitative traits (e.g., F cell levels) are highly heritable. We have previously mapped a major quantitative trait locus (QTL) controlling F cell levels in an extended Asian-Indian kindred wi