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We study the folding thermodynamics of a beta-hairpin and two three-stranded beta-sheet peptides using a simplified sequence-based all-atom model, in which folding is driven mainly by backbone hydrogen bonding and effective hydrophobic attraction. The native populations obtained for these three sequences are in good. agreement with experimental data. We also show that the apparent native populatio
A core-excited sulfur state with a lifetime almost one order of magnitude longer than in molecular 2p core-hole states is selectively produced by ultrafast dissociation of S 2p -> sigma* excited OCS. Clear evidence for this is provided by strong atomic peaks (20% of the total intensity) in x-ray fluorescence but very weak ones (2%) in the corresponding resonant Auger spectrum. Corroborating the as
Proliferation, differentiation, and survival of hematopoietic cells are regulated by cytokines, acting through specific receptors. FLT3 ligand (FL) is one of the most important cytokines for regulation of the hematopoietic system, and its receptor FLT3 is expressed on both stem cells and progenitors. Regulation of Forkhead transcription factors has been described as an important mechanism to contr
Detrusor biopsies were obtained from patients with urinary outlet obstruction due to prostatic enlargement and from age-matched control patients. The relative amounts of actin and myosin and their isoforms, as well as desmin and filamin were determined and compared with corresponding results from bladders from control rats and rats with 10 days of experimental outlet obstruction of the urinary bla
Rotational bands have been found in 57Co using the 28Si(32S,3p) reaction at 130 MeV. The bands, extending the mass 60 region of large deformation down to Z=27, are signature-partner sequences. Their quadrupole moments are similar to those of bands in the neighboring nuclei. The features of the new bands are described by Skyrme Hartree-Fock calculations favoring a configuration assignment with one
Abstract in German 62 anti-HCV und HCV-RNA-positive schwedische Blutspender (44 Männer, 18 Frauen, Alter im Median 34 Jahre) wurden untersucht. Die HCV-Genotypen wurden in Korrelation gesetzt zu parenteralen Risikofaktoren, Lebermorphologie, Serum-Alanin-Aminotransferase (ALAT)-Spiegeln und HCV-Antikörperprofil. 40% der Spender waren mit dem HCV-Genotyp 1a infiziert, 10% mit 1b, 21% mit 2b und 29%Sixty-two anti-HCV and HCV-RNA positive Swedish blood donors (44 men, 18 women; median age 34 years) were studied. HCV genotypes were correlated to parenteral risk factors, liver morphology, serum alanine aminotransferase (ALAT) levels and HCV antibody profile. Forty percent of the donors were infected with HCV genotype 1a, 10% with 1b, 21% with 2b, and 29% with 3a. Intravenous drug use (IVDU) was
We present simultaneous, quality fits to final BRAHMS, PHOBOS, STAR and PHENIX data on particle spectra and two-particle Bose-Einstein or HBT correlations as measured in Au+Au collisions at root(S)NN = 130 GeV. Using the Buda-Lund hydro model, the best fit is achieved when the most central 1/8th of the particle emitting volume is superheated to T > T-c = 170 MeV. In contrast, we find no indication
PURPOSE: To compare chemotherapy treatment monitoring in astrocytoma by 201thallium single photon emission computed tomography (SPECT) and photon magnetic resonance spectroscopy (1H-MRS) with magnetic resonance imaging (MRI), and to evaluate the influence of morphological tumor changes on cerebral 201thallium uptake and metabolic changes in 1H-MRS. MATERIALS AND METHODS: Six patients with highly m
The small Neogene Krong Pa graben is situated within the continental Song Ba Rift, which is bounded by strike-slip faults that were reactivated as extensional faults in Middle Miocene time. The 500 m thick graben-fill shows an overall depositional development reflecting the structural evolution, which is very similar to much larger and longer-lived graben. The basal graben-fill consists of thin fl
A patient undergoing cytostatic therapy for osteosarcoma of the right humerus had bone scans at 2-mo intervals. A skeletal focus of increased radiotracer accumulation occurred and subsequently was confirmed by CT and MRI. A necrotic metastasis was found during biopsy. There were no remaining viable tumor cells. This finding confirms the presence of the flare phenomenon in skeletal metastases in pr
Background Murray's Law states that, when a parent blood vessel branches into daughter vessels, the cube of the radius of the parent vessel is equal to the sum of the cubes of the radii of daughter blood vessels. Murray derived this law by defining a cost function that is the sum of the energy cost of the blood in a vessel and the energy cost of pumping blood through the vessel. The cost is minim
