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Antibody–enzyme complexes (AECs) are ideal for immunosensing. Although AECs using antibody fragments can be produced by bacterial hosts, their low affinity limits their sensing applications. We have improved the affinity of AECs by combining two antibodies using Catcher/Tag systems; however, it requires multiple antibodies and an enzyme production process. In this study, to realize the production

One challenge in the continuous monitoring of insulin lies with the unavailability of a high-affinity biological recognition element (BRE) with kinetic parameters sufficient to track fluctuating concentrations of insulin in vivo. An approach to overcome this limitation is to engineer a high-affinity BRE to selectively modulate its binding kinetics in response to an external signal. Herein, we desi

This article presents an innovative participatory approach to the ethical aspects of conducting body mapping research. Drawing from experiences from an earlier project with digital sex workers, we examine how body mapping, when integrated with what we term “embodied oscillative ethics,” creates opportunities for meaningful collaboration and knowledge co-creation while addressing complex ethical ch

PurposeTo investigate long-term effects of intravitreal injections on visual outcome, retinal function and structure in eyes with central retinal vein occlusion (CRVO eyes) and macular oedema and compare with untreated CRVO eyes to determine the long-term effects of anti-vascular endothelial growth factor on photoreceptor cell function.MethodsA retrospective study of 38 eyes from 38 CRVO patients.

This study examines shifts in Swedish media representations of refugees over three decades by analyzing coverage of refugees from Yugoslavia (1992), Syria (2015), and Ukraine (2022) in the newspaper Dagens Nyheter. Through frame analysis, the research reveals how media narratives reconcile Sweden’s humanitarian self-image with increasingly restrictive refugee policies. While institutional responsi

This paper deals with numerical investigations of cross laminated timber (CLT) beams. Previous investigations have revealed discrepancies between experimental test results and suggested design methods regarding shear force capacity of such beams. To gain further understanding of the failure behaviour and the shear force capacity, nonlinear finite element analyses have been performed, using a cohes

Between 2014 and 2022, Sweden introduced a feminist foreign policy (FFP), which entailed a “systematic gender equality perspective throughout foreign policy”. This chapter focuses on how FFP was practiced and implemented by officials at Swedish Embassies around the world. Using a framework of practice theory, implementation theory and feminist institutionalism, the overarching questions guiding th

Corruption is one of the most pressing and systemic issues of the 21st century,significantly hindering sustainable socio-economic development acrossnations. It undermines trust in authorities and legal institutions, which inturn diminishes investment activities, restricts entrepreneurial growth, andexacerbates social inequality. Kazakhstan, as a country actively working tomodernize public administ

Study region: The Brazilian wooded Cerrado biome is a tropical savanna, over 50 % of which has been converted to agricultural land. Study focus: We evaluated changes in water balance variables (surface flux, evaporation, soil-water storage, infiltration, groundwater recharge, and root uptake) due to climate change. The study included (i) calibration and validation of the Hydrus model through obser

Syftet med artikeln är att bidra med ny kunskap om hur en lektionsdesign, som tar utgångspunkt i litterära aspekter, kan möjliggöra utveckling av elevers läsförståelse i åk 4. En learning study med utgångspunkt i de litterära aspekterna: karaktärsbeskrivning, miljöbeskrivning, handling och tema genomfördes i tre klasser i årskurs 4 med 60 elever och tre lärare. Det empiriska materialet består av tThe article aims to provide new knowledge regarding how a teaching design, based on literary concepts, makes possible a deeper development of pupils’ reading comprehension in grade 4. A Learning study focusing on the literary concepts: character, setting, plot and themes was conducted in three classes in year 4 with 60 participating pupils and three participating teachers. The empi-rical material

The Gulf Cooperation Council (GCC) countries have experienced significant migration trends in recent decades, with a heavy reliance on foreign labour, particularly from Southern Asia. As of 2024, the GCC hosts 25 million migrants, with Southern Asians constituting a significant proportion. This demographic reality has shaped the region's socio-economic structure, with expatriates dominating the pr

I studien tillämpas en undervisningsdesign som sätter berättelser i olika uttrycksformer i centrum bland elever i lågstadiets årskurs 1. Syftet med studien är att undersöka lärares och elevers upplevelser och erfarenheter av att arbeta med undervisningsdesignen för att bidra med kunskap om hur undervisning med berättelsen i centrum kan möjliggöra och synliggöra elevers kommunikativa, kreativa och In the study, a teaching design that focuses on stories in various forms of expression is applied in the first-grade classroom. The aim of the study is to examine teachers’ and pupils’ experiences of working with this teaching design in order to contribute with knowledge regarding how story-centred teaching can make possible and make visible pupils’ communicative, creative, and narrative competenc

Syftet med artikeln är att illustrera vilka litterära iakttagelser några elever i årskurs fyra ger uttryck för när de läser berättelsen ”Draken med de röda ögonen” av Astrid Lindgren (1980) och hur dessa iakttagelser kan bidra med kunskap om vad som kan utgöra utgångspunkt och tas tillvara när en Litteraturundervisning planeras och genomförs på mellanstadiet. Datamaterialet består av nio semi-struThe aim of the article is to illustrate which literary observations nine pupils in year four express when they read the story "The Dragon with the Red Eyes" by Astrid Lindgren (1980), and how these observations can contribute with knowledge regarding what the lessons can be based on, and which aspects can be used when literature education is planned and carried out in middle school. The data mater

In response to the challenge to educate democratic citizens and prepare them for life in a global and digital world, a teaching design that focuses on stories that re-claim a place in the literary tradition for groups of people who have been marginalised or silenced in literary classics has been developed and implemented in the upper secondary EFL classroom. The aim of this article is to analyse e

The Eurasian Group on Combating Money Laundering and Financing of Terrorism (EAG), as a Financial Action Task Force (FATF)–style regional body (FSRB), synchronises national legislations across Central Asia to combat money laundering and financing terrorism through FATF mechanisms, aiming to eliminate external stresses on large economies. However, the hardening of FATF’s soft law approach through e

Extreme Value Theory (EVT) is the state-of-the-art method for proactive prediction of accident frequency from traffic interactions on a microscopic scale. The main advantage of using EVT is to predict unobserved critical events based on one or more Surrogate Measures of Safety (SMoS) (single- or multivariate EVT) through a mathematical extrapolation of extreme interactions. Such interactions are q

The significance of the great ape heritage to the evolution of human rhythmic competence — as manifested in speech, music and dance — has been greatly underestimated in both past and contemporary research. In this chapter we deconstruct received misconceptions about the rhythmic competence of the apes and defend the position that, contrary to the received view, the great apes likely constitute the

The purpose of this project was to find estimates of the operational releases of 14C and 3H from new SMR technology that is being considered in Sweden, namely the Rolls-Royce SMR and the GE-Hitachi BWRX-300. To achieve this goal, models of the reactors of interest were made in the continuous-energy Monte-Carlo neutron and photon transport code Serpent, where the production of 14C and 3H could then

In mouse early pachytene spermatocytes, the X and Y chromosomes undergo rapid non-homologous (NH) synapsis and desynapsis, but the functional significance remains unknown. Here, we report that pachynema-specific knockout of Speedy A (SpdyA) from telomeres caused persistent Y-X NH synapsis, with the entire Y axis synapsed onto the X axis. This persistent Y-X NH synapsis did not interrupt meiotic se